Skip to main content
Top
Published in: BMC Infectious Diseases 1/2017

Open Access 01-12-2017 | Research article

Six-monthly appointment spacing for clinical visits as a model for retention in HIV Care in Conakry-Guinea: a cohort study

Authors: Cavin Epie Bekolo, Abdourahimi Diallo, Mit Philips, Joseph-Desire Yuma, Letizia Di Stefano, Stéphanie Drèze, Jerome Mouton, Youssouf Koita, Ousseni W. Tiomtore

Published in: BMC Infectious Diseases | Issue 1/2017

Login to get access

Abstract

Background

The outbreak of the Ebola virus disease (EVD) in 2014 led to massive dropouts in HIV care in Guinea. Meanwhile, Médecins Sans Frontières (MSF) was implementing a six-monthly appointment spacing approach adapted locally as Rendez-vous de Six Mois (R6M) with an objective to improve retention in care. We sought to evaluate this innovative model of ART delivery in circumstances where access to healthcare is restricted.

Methods

A retrospective cohort study in 2014 of the outcome of a group of stable patients (viral load ≤1000 copies/μl) enrolled voluntarily in R6M compared with a group of stable patients continuing standard one to three monthly visits in Conakry. Log-rank test and Cox proportional hazards model were used to compare rates of attrition (deaths and defaulters) from care between the two groups. A linear regression analysis was used to describe the trend or pattern in the number of clinical visits over time.

Results

Included were 1957 adults of 15 years old and above of whom 1166 (59.6%) were enrolled in the R6M group and 791 (40.4%) in the standard care group. The proportion remaining in care at 18 months and beyond was 90% in the R6M group; significantly higher than the 75% observed in the control group (p < 0.0001). After adjusting for duration on ART and tuberculosis co-infection as covariates, the R6M strategy was associated with a 60% reduction in the rate of attrition from care compared with standard care (adjusted Hazard Ratio = 0.40, 95%CI: 0.27–0.59, p < 0.001). There was a negative secular trend in the number of monthly clinical visits for 24 months as the predicted caseload reduced on average by just below 50 visits per month (β = −48.6, R2 = 0.82, p < 0.0001).

Conclusion

R6M was likely to reduce staff workload and to mitigate attrition from ART care for stable patients in Conakry despite restricted access to healthcare caused by the devastating EVD on the health system in Guinea. R6M could be rolled out as the model of care for stable patients where and when feasible as a strategy likely to improve retention in HIV care.
Appendix
Available only for authorised users
Literature
1.
go back to reference WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. Geneva: World Health Organization; 2013. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. Geneva: World Health Organization; 2013.
3.
go back to reference WHO. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection recommendations for a public health approach. Geneva: World Health Organization; 2014. WHO. March 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection recommendations for a public health approach. Geneva: World Health Organization; 2014.
4.
go back to reference Joint United Nations Programme on HIV/AIDS (UNAIDS). 90–90–90 - An ambitious treatment target to help end the AIDS epidemic. In. Geneva; 2014. Joint United Nations Programme on HIV/AIDS (UNAIDS). 90–90–90 - An ambitious treatment target to help end the AIDS epidemic. In. Geneva; 2014.
5.
go back to reference WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. Geneva: World Health Organization; 2016. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach. Geneva: World Health Organization; 2016.
6.
go back to reference WHO. Retention in HIV programmes: Defining the challenges and identifying solutions Meeting report (13–15 September 2011, Geneva, Switzerland): World Health Organization; 2012. WHO. Retention in HIV programmes: Defining the challenges and identifying solutions Meeting report (13–15 September 2011, Geneva, Switzerland): World Health Organization; 2012.
7.
8.
go back to reference Ekouevi DK, Balestre E, Ba-Gomis FO, Eholie SP, Maiga M, Amani-Bosse C, Minga A, Messou E, Sow PS, Lewden C, et al. Low retention of HIV-infected patients on antiretroviral therapy in 11 clinical centres in West Africa. Trop Med Int Health. 2010;15(Suppl 1):34–42.CrossRefPubMedPubMedCentral Ekouevi DK, Balestre E, Ba-Gomis FO, Eholie SP, Maiga M, Amani-Bosse C, Minga A, Messou E, Sow PS, Lewden C, et al. Low retention of HIV-infected patients on antiretroviral therapy in 11 clinical centres in West Africa. Trop Med Int Health. 2010;15(Suppl 1):34–42.CrossRefPubMedPubMedCentral
9.
go back to reference Bemelmans M, Baert S, Goemaere E, Wilkinson L, Vandendyck M, van Cutsem G, Silva C, Perry S, Szumilin E, Gerstenhaber R, et al. Community-supported models of care for people on HIV treatment in sub-Saharan Africa. Trop Med Int Health. 2014;19(8):968–77.CrossRefPubMed Bemelmans M, Baert S, Goemaere E, Wilkinson L, Vandendyck M, van Cutsem G, Silva C, Perry S, Szumilin E, Gerstenhaber R, et al. Community-supported models of care for people on HIV treatment in sub-Saharan Africa. Trop Med Int Health. 2014;19(8):968–77.CrossRefPubMed
10.
go back to reference Nakiwogga-Muwanga A, Katabira E, Kiragga A, Kambugu A, Nakibuuka-Lubwama E, Manabe YC, Alamo ST, Colebunders R. Factors before enrolment are associated with being removed from a pharmacy-only refill Programme at a large urban HIV/AIDS clinic, Uganda. Int J STD AIDS. 2014;25(2):105–12.CrossRefPubMed Nakiwogga-Muwanga A, Katabira E, Kiragga A, Kambugu A, Nakibuuka-Lubwama E, Manabe YC, Alamo ST, Colebunders R. Factors before enrolment are associated with being removed from a pharmacy-only refill Programme at a large urban HIV/AIDS clinic, Uganda. Int J STD AIDS. 2014;25(2):105–12.CrossRefPubMed
11.
go back to reference Nickerson JW, Hatcher-Roberts J, Adams O, Attaran A, Tugwell P. Assessments of health services availability in humanitarian emergencies: a review of assessments in Haiti and Sudan using a health systems approach. Confl Health. 2015;9:20.CrossRefPubMedPubMedCentral Nickerson JW, Hatcher-Roberts J, Adams O, Attaran A, Tugwell P. Assessments of health services availability in humanitarian emergencies: a review of assessments in Haiti and Sudan using a health systems approach. Confl Health. 2015;9:20.CrossRefPubMedPubMedCentral
12.
go back to reference Comité National de Lutte contre le Sida (CNLS). Rapport National de la Riposte VIH/SIDA 2014 [Progres 2010–2014] en Guinee. In. Conakry; 2015. Comité National de Lutte contre le Sida (CNLS). Rapport National de la Riposte VIH/SIDA 2014 [Progres 2010–2014] en Guinee. In. Conakry; 2015.
13.
go back to reference Leuenberger D, Hebelamou J, Strahm S, De Rekeneire N, Balestre E, Wandeler G, Dabis F. Impact of the Ebola epidemic on general and HIV care in Macenta, Forest Guinea, 2014. AIDS. 2015;29(14):1883–7.CrossRefPubMedPubMedCentral Leuenberger D, Hebelamou J, Strahm S, De Rekeneire N, Balestre E, Wandeler G, Dabis F. Impact of the Ebola epidemic on general and HIV care in Macenta, Forest Guinea, 2014. AIDS. 2015;29(14):1883–7.CrossRefPubMedPubMedCentral
14.
go back to reference Ndawinz JD, Cisse M, Diallo MS, Sidibe CT, D'Ortenzio E. Prevention of HIV spread during the Ebola outbreak in Guinea. Lancet. 2015;385(9976):1393.CrossRefPubMed Ndawinz JD, Cisse M, Diallo MS, Sidibe CT, D'Ortenzio E. Prevention of HIV spread during the Ebola outbreak in Guinea. Lancet. 2015;385(9976):1393.CrossRefPubMed
15.
go back to reference Brolin Ribacke KJ, Saulnier DD, Eriksson A, von Schreeb J. Effects of the West Africa Ebola virus disease on health-care utilization - a systematic review. Front Public Health. 2016;4:222.CrossRefPubMedPubMedCentral Brolin Ribacke KJ, Saulnier DD, Eriksson A, von Schreeb J. Effects of the West Africa Ebola virus disease on health-care utilization - a systematic review. Front Public Health. 2016;4:222.CrossRefPubMedPubMedCentral
17.
go back to reference Médecins Sans Frontières (MSF). Out of Focus: How millions of people in West and Central Africa are being left out of the global HIV response. In. Brussels. 2016. Médecins Sans Frontières (MSF). Out of Focus: How millions of people in West and Central Africa are being left out of the global HIV response. In. Brussels. 2016.
19.
go back to reference Pathmanathan I, Pevzner ES, Marston BJ, Hader SL, Dokubo EK. Insights from the Ebola response to address HIV and tuberculosis. Lancet Infect Dis. 2016;16(3):276–8.CrossRefPubMedPubMedCentral Pathmanathan I, Pevzner ES, Marston BJ, Hader SL, Dokubo EK. Insights from the Ebola response to address HIV and tuberculosis. Lancet Infect Dis. 2016;16(3):276–8.CrossRefPubMedPubMedCentral
20.
go back to reference Kieny MP, Evans DB, Schmets G, Kadandale S. Health-system resilience: reflections on the Ebola crisis in western Africa. Bull World Health Organ. 2014;92(12):850.CrossRefPubMedPubMedCentral Kieny MP, Evans DB, Schmets G, Kadandale S. Health-system resilience: reflections on the Ebola crisis in western Africa. Bull World Health Organ. 2014;92(12):850.CrossRefPubMedPubMedCentral
21.
go back to reference McGuire M, Pedrono G, Mukhuna B, Huckabee M, Heinzelmann A, Szumilin E, Chikwaza O, Pujades-Rodriguez M. Optimizing patient monitoring after the first year of ART: three years of implementing 6-monthly clinical appointments in rural Malawi. In: 6th IAS conference on HIV pathogenesis, treatment and prevention: 2011. The International AIDS Society: Rome, Italy; 2011. McGuire M, Pedrono G, Mukhuna B, Huckabee M, Heinzelmann A, Szumilin E, Chikwaza O, Pujades-Rodriguez M. Optimizing patient monitoring after the first year of ART: three years of implementing 6-monthly clinical appointments in rural Malawi. In: 6th IAS conference on HIV pathogenesis, treatment and prevention: 2011. The International AIDS Society: Rome, Italy; 2011.
22.
go back to reference Vittinghoff EGD, Shiboski SC, CE MC. Regression methods in biostatistics. Boston, MA: Springer US; 2012.CrossRef Vittinghoff EGD, Shiboski SC, CE MC. Regression methods in biostatistics. Boston, MA: Springer US; 2012.CrossRef
24.
go back to reference Médecins Sans Frontières (MSF). Reaching Closer to Home Progress implementing community-based and other adherence strategies supporting people on HIV treatment. Experiences from DRC, Lesotho, Malawi, Mozambique, South Africa & Zimbabwe. In. Brussels. 2013. Médecins Sans Frontières (MSF). Reaching Closer to Home Progress implementing community-based and other adherence strategies supporting people on HIV treatment. Experiences from DRC, Lesotho, Malawi, Mozambique, South Africa & Zimbabwe. In. Brussels. 2013.
25.
go back to reference Hill AM, Pozniak AN, Dauncey T, Levi J, Heath K, Essajee S, Elias CP. Countries with lower HIV prevalence have lower ARV coverage: UNAIDS 2015 database. In: Conference on retroviruses and opportunistic Iinfections 2016. Boston, Massachusetts: IAS–USA/CROI Foundation. p. 2016. Hill AM, Pozniak AN, Dauncey T, Levi J, Heath K, Essajee S, Elias CP. Countries with lower HIV prevalence have lower ARV coverage: UNAIDS 2015 database. In: Conference on retroviruses and opportunistic Iinfections 2016. Boston, Massachusetts: IAS–USA/CROI Foundation. p. 2016.
26.
go back to reference Comité National de Lutte contre le Sida (CNLS). Revue des progrès vers la réalisation des cibles de la déclaration 2011 de l’ONU sur le VIH et le Sida en Guinee. Rapport narratif 2014. In. Conakry. 2014: 36. Comité National de Lutte contre le Sida (CNLS). Revue des progrès vers la réalisation des cibles de la déclaration 2011 de l’ONU sur le VIH et le Sida en Guinee. Rapport narratif 2014. In. Conakry. 2014: 36.
27.
go back to reference Rutherford GW AA, Easterbrook PJ, Horvath T, Vitoria M, Penazzato M, Doherty MC: Predicting treatment failure in adults and children on antiretroviral therapy: a systematic review of the performance characteristics of the 2010 WHO immunologic and clinical criteria for virologic failure. AIDS 2014, 28:161– 169. Rutherford GW AA, Easterbrook PJ, Horvath T, Vitoria M, Penazzato M, Doherty MC: Predicting treatment failure in adults and children on antiretroviral therapy: a systematic review of the performance characteristics of the 2010 WHO immunologic and clinical criteria for virologic failure. AIDS 2014, 28:161– 169.
28.
go back to reference Campbell JL, Howie JG. Changes resulting from increasing appointment length: practical and theoretical issues. Br J Gen Pract. 1992;42(360):276–8.PubMedPubMedCentral Campbell JL, Howie JG. Changes resulting from increasing appointment length: practical and theoretical issues. Br J Gen Pract. 1992;42(360):276–8.PubMedPubMedCentral
29.
go back to reference Holden RJ, Scanlon MC, Patel NR, Kaushal R, Escoto KH, Brown RL, Alper SJ, Arnold JM, Shalaby TM, Murkowski K, et al. A human factors framework and study of the effect of nursing workload on patient safety and employee quality of working life. BMJ Qual Saf. 2011;20(1):15–24.CrossRefPubMedPubMedCentral Holden RJ, Scanlon MC, Patel NR, Kaushal R, Escoto KH, Brown RL, Alper SJ, Arnold JM, Shalaby TM, Murkowski K, et al. A human factors framework and study of the effect of nursing workload on patient safety and employee quality of working life. BMJ Qual Saf. 2011;20(1):15–24.CrossRefPubMedPubMedCentral
30.
go back to reference Portoghese I, Galletta M, Coppola RC, Finco G, Campagna M. Burnout and workload among health care workers: the moderating role of job control. Saf Health Work. 2014;5(3):152–7.CrossRefPubMedPubMedCentral Portoghese I, Galletta M, Coppola RC, Finco G, Campagna M. Burnout and workload among health care workers: the moderating role of job control. Saf Health Work. 2014;5(3):152–7.CrossRefPubMedPubMedCentral
31.
go back to reference Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR. Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. Int J Epidemiol. 2016;45(1):102–16.CrossRefPubMed Brainard J, Hooper L, Pond K, Edmunds K, Hunter PR. Risk factors for transmission of Ebola or Marburg virus disease: a systematic review and meta-analysis. Int J Epidemiol. 2016;45(1):102–16.CrossRefPubMed
Metadata
Title
Six-monthly appointment spacing for clinical visits as a model for retention in HIV Care in Conakry-Guinea: a cohort study
Authors
Cavin Epie Bekolo
Abdourahimi Diallo
Mit Philips
Joseph-Desire Yuma
Letizia Di Stefano
Stéphanie Drèze
Jerome Mouton
Youssouf Koita
Ousseni W. Tiomtore
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2017
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-017-2826-6

Other articles of this Issue 1/2017

BMC Infectious Diseases 1/2017 Go to the issue