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Open Access 01-12-2017 | Research article

Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory

Authors: Lander Bosch, Barbara Bosch, Kris De Boeck, Tim Nawrot, Isabelle Meyts, Dominique Vanneste, Cleonice Alexandre Le Bourlegat, Julio Croda, Luiz Vicente Ribeiro Ferreira da Silva Filho

Published in: BMC Infectious Diseases | Issue 1/2017

Abstract

Background

The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection.

Methods

Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis (TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis.

Results

A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found.

Conclusion

We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections.

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Title: Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
Authors: Lander Bosch
Barbara Bosch
Kris De Boeck
Tim Nawrot
Isabelle Meyts
Dominique Vanneste
Cleonice Alexandre Le Bourlegat
Julio Croda
Luiz Vicente Ribeiro Ferreira da Silva Filho
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: BMC Infectious Diseases / Issue 1/2017
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-017-2448-z

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