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Published in: BMC Infectious Diseases 1/2016

Open Access 01-12-2016 | Case report

Louse-borne relapsing fever – report of four cases in Switzerland, June-December 2015

Authors: Michael Osthoff, Adrian Schibli, Davide Fadini, Pietro Lardelli, Daniel Goldenberger

Published in: BMC Infectious Diseases | Issue 1/2016

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Abstract

Background

Louse-borne relapsing fever (LBRF) is a neglected disease that has been restricted to East Africa for many decades. Several cases in refugees from the Horn of Africa have been recently diagnosed in four European countries.

Case presentation

We report four additional cases of LBRF in asylum seekers from Somalia and Eritrea who presented with fever shortly after arriving in Switzerland during a seven-month period. Multiple spirochetes were visualized on stained blood films which were identified as Borrelia recurrentis by 16S rRNA gene sequencing. All patients recovered after antibiotic treatment with ceftriaxone and/or doxycycline. Concurrent infections (malaria and tuberculosis) were diagnosed in half of our patients. Possible modes of transmission and preventive measures are discussed.

Conclusions

These reported cases highlight the ongoing transmission of LBRF in migrants from East Africa. Diagnosis of LBRF cases and prevention of autochthonous transmission in asylum seeker camps are important steps for the near future.
Literature
1.
2.
go back to reference Yimer M, Mulu W, Ayalew W, Abera B. Louse-borne relapsing fever profile at Felegehiwot referral hospital, Bahir Dar city, Ethiopia: a retrospective study. BMC Res Notes. 2014;7:250.CrossRefPubMedPubMedCentral Yimer M, Mulu W, Ayalew W, Abera B. Louse-borne relapsing fever profile at Felegehiwot referral hospital, Bahir Dar city, Ethiopia: a retrospective study. BMC Res Notes. 2014;7:250.CrossRefPubMedPubMedCentral
3.
go back to reference Raoult D, Roux V. The body louse as a vector of reemerging human diseases. Clin Infect Dis. 1999;29(4):888–911.CrossRefPubMed Raoult D, Roux V. The body louse as a vector of reemerging human diseases. Clin Infect Dis. 1999;29(4):888–911.CrossRefPubMed
4.
go back to reference Goldenberger D, Claas GJ, Bloch-Infanger C, Breidthardt T, Suter B, Martinez M, Neumayr A, Blaich A, Egli A, Osthoff M. Louse-borne relapsing fever (Borrelia recurrentis) in an Eritrean refugee arriving in Switzerland, August 2015. Euro Surveill. 2015;20(32):2–5.CrossRefPubMed Goldenberger D, Claas GJ, Bloch-Infanger C, Breidthardt T, Suter B, Martinez M, Neumayr A, Blaich A, Egli A, Osthoff M. Louse-borne relapsing fever (Borrelia recurrentis) in an Eritrean refugee arriving in Switzerland, August 2015. Euro Surveill. 2015;20(32):2–5.CrossRefPubMed
5.
go back to reference Guerrier G, Doherty T. Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. Trans R Soc Trop Med Hyg. 2011;105(9):483–90.CrossRefPubMed Guerrier G, Doherty T. Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. Trans R Soc Trop Med Hyg. 2011;105(9):483–90.CrossRefPubMed
6.
go back to reference Ciervo A, Mancini F, di Bernardo F, Giammanco A, Vitale G, Dones P, Faciana T, Quartaro P, Mazzola G, Rezza G. Louse-borne relapsing fever in young migrants, Sicily, Italy, July–September 2015. Emerg Infect Dis j. 2016;22(1):152–3. Ciervo A, Mancini F, di Bernardo F, Giammanco A, Vitale G, Dones P, Faciana T, Quartaro P, Mazzola G, Rezza G. Louse-borne relapsing fever in young migrants, Sicily, Italy, July–September 2015. Emerg Infect Dis j. 2016;22(1):152–3.
7.
go back to reference Lucchini A, Lipani F, Costa C, Scarvaglieri M, Balbiano R, Carosella S, Calcagno A, Audagnotto S, Barbui AM, Brossa S, et al. Louseborne relapsing fever among East African refugees, Italy, 2015. Emerg Infect Dis j. 2016;22(2):298–301.CrossRef Lucchini A, Lipani F, Costa C, Scarvaglieri M, Balbiano R, Carosella S, Calcagno A, Audagnotto S, Barbui AM, Brossa S, et al. Louseborne relapsing fever among East African refugees, Italy, 2015. Emerg Infect Dis j. 2016;22(2):298–301.CrossRef
8.
go back to reference Hoch M, Wieser A, Loscher T, Margos G, Purner F, Zuhl J, Seilmaier M, Balzer L, Guggemos W, Rack-Hoch A, et al. Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015. Euro Surveill. 2015;20(42):6–10. Hoch M, Wieser A, Loscher T, Margos G, Purner F, Zuhl J, Seilmaier M, Balzer L, Guggemos W, Rack-Hoch A, et al. Louse-borne relapsing fever (Borrelia recurrentis) diagnosed in 15 refugees from northeast Africa: epidemiology and preventive control measures, Bavaria, Germany, July to October 2015. Euro Surveill. 2015;20(42):6–10.
9.
go back to reference Wilting KR, Stienstra Y, Sinha B, Braks M, Cornish D, Grundmann H. Louse-borne relapsing fever (Borrelia recurrentis) in asylum seekers from Eritrea, the Netherlands, July 2015. Euro Surveill. 2015;20(30):2–4. Wilting KR, Stienstra Y, Sinha B, Braks M, Cornish D, Grundmann H. Louse-borne relapsing fever (Borrelia recurrentis) in asylum seekers from Eritrea, the Netherlands, July 2015. Euro Surveill. 2015;20(30):2–4.
10.
go back to reference Lescot M, Audic S, Robert C, Nguyen TT, Blanc G, Cutler SJ, Wincker P, Couloux A, Claverie JM, Raoult D, et al. The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. PLoS Genet. 2008;4(9):e1000185.CrossRefPubMedPubMedCentral Lescot M, Audic S, Robert C, Nguyen TT, Blanc G, Cutler SJ, Wincker P, Couloux A, Claverie JM, Raoult D, et al. The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. PLoS Genet. 2008;4(9):e1000185.CrossRefPubMedPubMedCentral
Metadata
Title
Louse-borne relapsing fever – report of four cases in Switzerland, June-December 2015
Authors
Michael Osthoff
Adrian Schibli
Davide Fadini
Pietro Lardelli
Daniel Goldenberger
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2016
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-016-1541-z

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