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BMC Geriatrics

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Open Access 01-12-2021 | Affective Disorder | Research

Prognostic factors of depression and depressive symptoms after hip fracture surgery: systematic review

Authors: R. Milton-Cole, S. Ayis, K. Lambe, M. D. L. O’Connell, C. Sackley, K. J. Sheehan

Published in: BMC Geriatrics | Issue 1/2021

Abstract

Background

Patients with hip fracture and depression are less likely to recover functional ability. This review sought to identify prognostic factors of depression or depressive symptoms up to 1 year after hip fracture surgery in adults. This review also sought to describe proposed underlying mechanisms for their association with depression or depressive symptoms.

Methods

We searched for published (MEDLINE, Embase, PsychInfo, CINAHL and Web of Science Core Collection) and unpublished (OpenGrey, Greynet, BASE, conference proceedings) studies. We did not impose any date, geographical, or language limitations. Screening (Covidence), extraction (Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies, adapted for use with prognostic factors studies Checklist), and quality appraisal (Quality in Prognosis Studies tool) were completed in duplicate. Results were summarised narratively.

Results

In total, 37 prognostic factors were identified from 12 studies included in this review. The quality of the underlying evidence was poor, with all studies at high risk of bias in at least one domain. Most factors did not have a proposed mechanism for the association. Where factors were investigated by more than one study, the evidence was often conflicting.

Conclusion

Due to conflicting and low quality of available evidence it is not possible to make clinical recommendations based on factors prognostic of depression or depressive symptoms after hip fracture. Further high-quality research investigating prognostic factors is warranted to inform future intervention and/or stratified approaches to care after hip fracture.

Trial registration

Prospero registration: CRD42019138690.

Available only for authorised users

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Title: Prognostic factors of depression and depressive symptoms after hip fracture surgery: systematic review
Authors: R. Milton-Cole
S. Ayis
K. Lambe
M. D. L. O’Connell
C. Sackley
K. J. Sheehan
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Affective Disorder
Affective Disorder
Published in: BMC Geriatrics / Issue 1/2021
Electronic ISSN: 1471-2318
DOI: https://doi.org/10.1186/s12877-021-02514-1

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