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Open Access 01-12-2021 | Research

Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity

Authors: Ya-Ping Lee, Chin-Hao Chang, Chin-Ying Chen, Chiung-Jung Wen, Hsien-Liang Huang, Jen-Kuei Peng, Yu-Ting Wang, Ching-Yu Chen, Jaw-Shiun Tsai

Published in: BMC Geriatrics | Issue 1/2021

Abstract

Background

Adiponectin and zinc alpha2-glycoprotein (ZAG) are associated with frailty. This study aims to further examine the association of adiponectin with ZAG.

Methods

Outpatients aged 65 years or older with chronic disease followed up in a hospital-based program were recruited for a comprehensive geriatric assessment. We excluded outpatients who were bedridden, residing in a nursing home, with expected life expectancy less than 6 months, or with severe hearing or communication impairment. Plasma ZAG and adiponectin levels were measured. Association between plasma ZAG and adiponectin levels was analyzed by univariate and multivariable linear regression analyses.

Results

A total of 189 older adults were enrolled (91 men and 98 women, mean age: 77.2 ± 6.1 years). Log-transformed plasma ZAG level was 1.82 ± 0.11 μg/mL, and it was significantly higher in men than that in women (1.85 ± 0.12 vs 1.79 ± 0.10 μg/mL, P = .0006). Log-transformed plasma adiponectin level was 1.00 ± 0.26 μg/mL, and there was no significant gender difference (P = .195). Overall, plasma ZAG level positively correlated with plasma adiponectin level in the multivariable linear regression analysis (P = .0085). The gender-specific significance, however, was less clear: this relationship was significant in men (P = .0049) but not in women (P = .2072). To be more specific by frailty phenotype components, plasma adiponectin was positively correlated with weight loss (P = .0454) and weakness (P = .0451).

Conclusions

Both of ZAG and adiponectin may be potential frailty biomarkers. Plasma ZAG is an independent factor of plasma adiponectin, especially in older male adults.

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Title: Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity
Authors: Ya-Ping Lee
Chin-Hao Chang
Chin-Ying Chen
Chiung-Jung Wen
Hsien-Liang Huang
Jen-Kuei Peng
Yu-Ting Wang
Ching-Yu Chen
Jaw-Shiun Tsai
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: BMC Geriatrics / Issue 1/2021
Electronic ISSN: 1471-2318
DOI: https://doi.org/10.1186/s12877-021-02379-4

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Correlation between plasma ZAG and adiponectin in older adults: gender modification and frailty specificity

Abstract

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Results

Conclusions

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