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Published in: BMC Geriatrics 1/2019

Open Access 01-12-2019 | Affective Disorder | Research article

Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period

Authors: Leonie Klompstra, Anne W. Ekdahl, Barbro Krevers, Anna Milberg, Jeanette Eckerblad

Published in: BMC Geriatrics | Issue 1/2019

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Abstract

Background

The prevalence of multimorbidity is increasing worldwide, and older people with multimorbidity are frequent users of health care services. Since multimorbidity has a significant negative impact on Health-related Quality of Life (HrQoL) and is more common in older age it would be expected that factors related to HrQoL in this group might have been thoroughly researched, but this is not the case. Furthermore, it is important to look at old people living at home, considering the shift from residential to home-based care. Therefore, we aim to investigate factors that are related to HrQoL in older people with multimorbidity and high health care consumption, living at home.

Methods

This is a secondary analysis of a RCT study conducted in a municipality in south-eastern Sweden. The study had a longitudinal design with a two-year follow-up period assessing HrQoL, symptom burden, activities of daily living, physical activity and depression.

Results

In total, 238 older people with multimorbidity and high health care consumption, living at home were included (mean age 82, 52% female). A multiple linear regression model including symptom burden, activities of daily living and depression as independent variables explained 64% of the HrQoL. Higher symptom burden, lower ability in activities of daily living and a higher degree of depression were negatively related to HrQoL. Depression at baseline and a change in symptom burden over a two-year period explained 28% of the change in HrQoL over a two-year period variability. A higher degree of depression at baseline and negative change in higher symptom burden were related to a decrease in HrQoL over a two-year period.

Conclusion

In order to facilitate better delivery of appropriate health care to older people with high health care consumption living at home it is important to assess HrQoL, and HrQoL over time. Symptom burden, activities of daily living, depression and change in symptom burden over time are important indicators for HrQoL.

Trial registration

Clinicaltrials.gov identifier: NCT01446757, the trial was registered prospectively with the date of trial registration October 5th, 2011.
Literature
1.
go back to reference Fortin M, Stewart M, Poitras M-E, Almirall J, Maddocks H. A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012;10(2):142–51.PubMedCentralCrossRefPubMed Fortin M, Stewart M, Poitras M-E, Almirall J, Maddocks H. A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med. 2012;10(2):142–51.PubMedCentralCrossRefPubMed
2.
go back to reference Glynn LG, Valderas JM, Healy P, et al. The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Fam Pract. 2011;28(5):516–23.CrossRefPubMed Glynn LG, Valderas JM, Healy P, et al. The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Fam Pract. 2011;28(5):516–23.CrossRefPubMed
3.
4.
go back to reference Goodman RA, Posner SF, Huang ES, Parekh AK, Koh HK. Peer reviewed: defining and measuring chronic conditions: imperatives for research, policy, program, and practice. Prev Chronic Dis. 2013;10:E66.PubMedCentralPubMed Goodman RA, Posner SF, Huang ES, Parekh AK, Koh HK. Peer reviewed: defining and measuring chronic conditions: imperatives for research, policy, program, and practice. Prev Chronic Dis. 2013;10:E66.PubMedCentralPubMed
5.
go back to reference van Oostrom SH, Picavet HSJ, van Gelder BM, et al. Multimorbidity and comorbidity in the Dutch population–data from general practices. BMC Public Health. 2012;12(1):715.PubMedCentralCrossRefPubMed van Oostrom SH, Picavet HSJ, van Gelder BM, et al. Multimorbidity and comorbidity in the Dutch population–data from general practices. BMC Public Health. 2012;12(1):715.PubMedCentralCrossRefPubMed
6.
go back to reference Smith SM, Soubhi H, Fortin M, Hudon C, O’Dowd T. Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. BMJ. 2012;345:e5205.PubMedCentralCrossRefPubMed Smith SM, Soubhi H, Fortin M, Hudon C, O’Dowd T. Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. BMJ. 2012;345:e5205.PubMedCentralCrossRefPubMed
7.
go back to reference WHO. Global status report on noncommunicable diseases 2014. 2014. Accessed 13 Sept 2015. WHO. Global status report on noncommunicable diseases 2014. 2014. Accessed 13 Sept 2015.
8.
go back to reference Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162(20):2269–76.CrossRefPubMed Wolff JL, Starfield B, Anderson G. Prevalence, expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002;162(20):2269–76.CrossRefPubMed
9.
go back to reference Lehnert T, Heider D, Leicht H, et al. Health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev. 2011;68(4):387–420.CrossRefPubMed Lehnert T, Heider D, Leicht H, et al. Health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev. 2011;68(4):387–420.CrossRefPubMed
10.
go back to reference Vogeli C, Shields AE, Lee TA, et al. Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. J Gen Intern Med. 2007;22:391–5.PubMedCentralCrossRefPubMed Vogeli C, Shields AE, Lee TA, et al. Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. J Gen Intern Med. 2007;22:391–5.PubMedCentralCrossRefPubMed
11.
go back to reference Marengoni A, Angleman S, Melis R, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430–9.CrossRefPubMed Marengoni A, Angleman S, Melis R, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430–9.CrossRefPubMed
13.
go back to reference Pisu M, Azuero A, Halilova KI, et al. Most impactful factors on the health-related quality of life of a geriatric population with cancer. Cancer. 2018;124(3):596–605.CrossRefPubMed Pisu M, Azuero A, Halilova KI, et al. Most impactful factors on the health-related quality of life of a geriatric population with cancer. Cancer. 2018;124(3):596–605.CrossRefPubMed
14.
go back to reference Walke LM, Byers AL, Gallo WT, Endrass J, Fried TR. The association of symptoms with health outcomes in chronically ill adults. J Pain Symptom Manag. 2007;33(1):58–66.CrossRef Walke LM, Byers AL, Gallo WT, Endrass J, Fried TR. The association of symptoms with health outcomes in chronically ill adults. J Pain Symptom Manag. 2007;33(1):58–66.CrossRef
15.
go back to reference Zambroski CH, Moser DK, Bhat G, Ziegler C. Impact of symptom prevalence and symtom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs. 2005;4(3):198–206.CrossRefPubMed Zambroski CH, Moser DK, Bhat G, Ziegler C. Impact of symptom prevalence and symtom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs. 2005;4(3):198–206.CrossRefPubMed
16.
go back to reference Eckerblad J, Theander K, Ekdahl A, et al. Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study. BMC Geriatr. 2015;15:1.PubMedCentralCrossRefPubMed Eckerblad J, Theander K, Ekdahl A, et al. Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study. BMC Geriatr. 2015;15:1.PubMedCentralCrossRefPubMed
17.
go back to reference Vaughan L, Leng X, La Monte MJ, Tindle HA, Cochrane BB, Shumaker SA. Functional Independence in late-life: maintaining physical functioning in older adulthood predicts daily life function after age 80. J Gerontol A. 2016;71(Suppl_1):S79–86.CrossRef Vaughan L, Leng X, La Monte MJ, Tindle HA, Cochrane BB, Shumaker SA. Functional Independence in late-life: maintaining physical functioning in older adulthood predicts daily life function after age 80. J Gerontol A. 2016;71(Suppl_1):S79–86.CrossRef
18.
go back to reference Molton IR, Terrill AL. Overview of persistent pain in older adults. Am Psychol. 2014;69(2):197–207.CrossRefPubMed Molton IR, Terrill AL. Overview of persistent pain in older adults. Am Psychol. 2014;69(2):197–207.CrossRefPubMed
19.
go back to reference World Health Organisation. Global recommendations on physical activity for health. Geneva: World Health Organisation; 2010. World Health Organisation. Global recommendations on physical activity for health. Geneva: World Health Organisation; 2010.
20.
go back to reference Chodzko-Zajko WJ, Proctor DN, Singh MAF, et al. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510–30.CrossRefPubMed Chodzko-Zajko WJ, Proctor DN, Singh MAF, et al. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510–30.CrossRefPubMed
21.
go back to reference Paterson DH, Jones GR, Rice CL. Ageing and physical activity: evidence to develop exercise recommendations for older adults. Appl Physiol Nutr Metab. 2007;32(S2E):S69–S108.CrossRef Paterson DH, Jones GR, Rice CL. Ageing and physical activity: evidence to develop exercise recommendations for older adults. Appl Physiol Nutr Metab. 2007;32(S2E):S69–S108.CrossRef
22.
go back to reference Lin J-H, Huang M-W, Wang D-W, et al. Late-life depression and quality of life in a geriatric evaluation and management unit: an exploratory study. BMC Geriatr. 2014;14(1):77.PubMedCentralCrossRefPubMed Lin J-H, Huang M-W, Wang D-W, et al. Late-life depression and quality of life in a geriatric evaluation and management unit: an exploratory study. BMC Geriatr. 2014;14(1):77.PubMedCentralCrossRefPubMed
23.
go back to reference Chang-Quan H, Xue-Mei Z, Bi-Rong D, Zhen-Chan L, Ji-Rong Y, Qing-Xiu L. Health status and risk for depression among the elderly: a meta-analysis of published literature. Age Ageing. 2009;39(1):23–30.CrossRefPubMed Chang-Quan H, Xue-Mei Z, Bi-Rong D, Zhen-Chan L, Ji-Rong Y, Qing-Xiu L. Health status and risk for depression among the elderly: a meta-analysis of published literature. Age Ageing. 2009;39(1):23–30.CrossRefPubMed
24.
go back to reference Cherubini A, Oristrell J, Pla X, et al. The persistent exclusion of older patients from ongoing clinical trials regarding heart failure. Arch Intern Med. 2011;171(6):550–6.CrossRefPubMed Cherubini A, Oristrell J, Pla X, et al. The persistent exclusion of older patients from ongoing clinical trials regarding heart failure. Arch Intern Med. 2011;171(6):550–6.CrossRefPubMed
25.
go back to reference Zulman DM, Sussman JB, Chen X, Cigolle CT, Blaum CS, Hayward RA. Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med. 2011;26(7):783–90.PubMedCentralCrossRefPubMed Zulman DM, Sussman JB, Chen X, Cigolle CT, Blaum CS, Hayward RA. Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med. 2011;26(7):783–90.PubMedCentralCrossRefPubMed
26.
go back to reference Ekdahl AW, Wirehn AB, Alwin J, et al. Costs and effects of an ambulatory geriatric unit (the AGe-FIT study): a randomized controlled trial. J Am Med Dir Assoc. 2015;16(6):497–503.CrossRefPubMed Ekdahl AW, Wirehn AB, Alwin J, et al. Costs and effects of an ambulatory geriatric unit (the AGe-FIT study): a randomized controlled trial. J Am Med Dir Assoc. 2015;16(6):497–503.CrossRefPubMed
27.
go back to reference Hunt SM, McEwen J. The development of a subjective health indicator. Sociol Health Illn. 1980;2(3):231–46.CrossRefPubMed Hunt SM, McEwen J. The development of a subjective health indicator. Sociol Health Illn. 1980;2(3):231–46.CrossRefPubMed
28.
go back to reference Wiklund I, Romanus B, Hunt SM. Self-assessed disability in patients with arthrosis of the hip joint. Reliability of the Swedish version of the Nottingham health profile. Int Disabil Stud. 1988;10(4):159–63.CrossRefPubMed Wiklund I, Romanus B, Hunt SM. Self-assessed disability in patients with arthrosis of the hip joint. Reliability of the Swedish version of the Nottingham health profile. Int Disabil Stud. 1988;10(4):159–63.CrossRefPubMed
29.
go back to reference Carlsson E, Olsson SB, Hertervig E. The role of the nurse in enhancing quality of life in patients with an implantable cardioverter-defibrillator: the Swedish experience. Prog Cardiovasc Nurs. 2002;17(1):18–25.CrossRefPubMed Carlsson E, Olsson SB, Hertervig E. The role of the nurse in enhancing quality of life in patients with an implantable cardioverter-defibrillator: the Swedish experience. Prog Cardiovasc Nurs. 2002;17(1):18–25.CrossRefPubMed
30.
go back to reference Portenoy RK, Thaler HT, Kornblith AB, et al. The memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer. 1994;30A(9):1326–36.CrossRefPubMed Portenoy RK, Thaler HT, Kornblith AB, et al. The memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer. 1994;30A(9):1326–36.CrossRefPubMed
31.
go back to reference Browall M, Kenne Sarenmalm E, Nasic S, Wengstrom Y, Gaston-Johansson F. Validity and reliability of the Swedish version of the memorial symptom assessment scale (MSAS): an instrument for the evaluation of symptom prevalence, characteristics, and distress. J Pain Symptom Manag. 2013;46(1):131–41.CrossRef Browall M, Kenne Sarenmalm E, Nasic S, Wengstrom Y, Gaston-Johansson F. Validity and reliability of the Swedish version of the memorial symptom assessment scale (MSAS): an instrument for the evaluation of symptom prevalence, characteristics, and distress. J Pain Symptom Manag. 2013;46(1):131–41.CrossRef
32.
go back to reference Pettersson G, Berterö C, Unosson M, Börjeson S. Symptom prevalence, frequency, severity, and distress during chemotherapy for patients with colorectal cancer. Support Care Cancer. 2014;22(5):1171–9.CrossRefPubMed Pettersson G, Berterö C, Unosson M, Börjeson S. Symptom prevalence, frequency, severity, and distress during chemotherapy for patients with colorectal cancer. Support Care Cancer. 2014;22(5):1171–9.CrossRefPubMed
33.
go back to reference Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61–5.PubMed Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61–5.PubMed
34.
go back to reference Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke trials. Stroke. 1999;30(8):1538–41.CrossRefPubMed Sulter G, Steen C, De Keyser J. Use of the Barthel index and modified Rankin scale in acute stroke trials. Stroke. 1999;30(8):1538–41.CrossRefPubMed
35.
go back to reference Hurtig-Wennlöf A, Hagströmer M, Olsson LA. The international physical activity questionnaire modified for the elderly: aspects of validity and feasibility. Public Health Nutr. 2010;13(11):1847–54.CrossRefPubMed Hurtig-Wennlöf A, Hagströmer M, Olsson LA. The international physical activity questionnaire modified for the elderly: aspects of validity and feasibility. Public Health Nutr. 2010;13(11):1847–54.CrossRefPubMed
36.
go back to reference Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95.CrossRefPubMed Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95.CrossRefPubMed
37.
go back to reference Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17(1):37–49.CrossRefPubMed Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17(1):37–49.CrossRefPubMed
38.
go back to reference D'Ath P, Katona P, Mullan E, Evans S, Katona C. Screening, detection and management of depression in elderly primary care attenders. I: the acceptability and performance of the 15 item geriatric depression scale (GDS15) and the development of short versions. Fam Pract. 1994;11(3):260–6.CrossRefPubMed D'Ath P, Katona P, Mullan E, Evans S, Katona C. Screening, detection and management of depression in elderly primary care attenders. I: the acceptability and performance of the 15 item geriatric depression scale (GDS15) and the development of short versions. Fam Pract. 1994;11(3):260–6.CrossRefPubMed
39.
go back to reference Conradsson M, Rosendahl E, Littbrand H, Gustafson Y, Olofsson B, Lovheim H. Usefulness of the geriatric depression scale 15-item version among very old people with and without cognitive impairment. Aging Ment Health. 2013;17(5):638–45.PubMedCentralCrossRefPubMed Conradsson M, Rosendahl E, Littbrand H, Gustafson Y, Olofsson B, Lovheim H. Usefulness of the geriatric depression scale 15-item version among very old people with and without cognitive impairment. Aging Ment Health. 2013;17(5):638–45.PubMedCentralCrossRefPubMed
40.
go back to reference Heo S, Moser DK, Lennie TA, et al. Changes in heart failure symptoms are associated with changes in health-related quality of life over 12 months in patients with heart failure. J Cardiovasc Nurs. 2018;33(5):460-6.CrossRefPubMed Heo S, Moser DK, Lennie TA, et al. Changes in heart failure symptoms are associated with changes in health-related quality of life over 12 months in patients with heart failure. J Cardiovasc Nurs. 2018;33(5):460-6.CrossRefPubMed
41.
go back to reference Davison SN, Jhangri GS. Impact of pain and symptom burden on the health-related quality of life of hemodialysis patients. J Pain Symptom Manag. 2010;39(3):477–85.CrossRef Davison SN, Jhangri GS. Impact of pain and symptom burden on the health-related quality of life of hemodialysis patients. J Pain Symptom Manag. 2010;39(3):477–85.CrossRef
42.
go back to reference Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL. Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manag. 2008;35(6):594–603.CrossRef Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL. Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manag. 2008;35(6):594–603.CrossRef
43.
go back to reference Blinderman CD, Homel P, Billings JA, Tennstedt S, Portenoy RK. Symptom distress and quality of life in patients with advanced chronic obstructive pulmonary disease. J Pain Symptom Manag. 2009;38(1):115–23.CrossRef Blinderman CD, Homel P, Billings JA, Tennstedt S, Portenoy RK. Symptom distress and quality of life in patients with advanced chronic obstructive pulmonary disease. J Pain Symptom Manag. 2009;38(1):115–23.CrossRef
44.
go back to reference Kenne Sarenmalm E, Browall M, Gaston-Johansson F. Symptom burden clusters: a challenge for targeted symptom management. A longitudinal study examining symptom burden clusters in breast Cancer. J Pain Symptom Manag. 2014;47(4):731–41.CrossRef Kenne Sarenmalm E, Browall M, Gaston-Johansson F. Symptom burden clusters: a challenge for targeted symptom management. A longitudinal study examining symptom burden clusters in breast Cancer. J Pain Symptom Manag. 2014;47(4):731–41.CrossRef
45.
go back to reference Tyack Z, K-a F, Barnett A, Cornwell P, Kuys S, McPhail S. Predictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort study. Qual Life Res. 2016;25(10):2579–92.CrossRefPubMed Tyack Z, K-a F, Barnett A, Cornwell P, Kuys S, McPhail S. Predictors of health-related quality of life in people with a complex chronic disease including multimorbidity: a longitudinal cohort study. Qual Life Res. 2016;25(10):2579–92.CrossRefPubMed
46.
go back to reference Vagetti GC, Barbosa Filho VC, Moreira NB, Oliveira V, Mazzardo O, Campos W. Association between physical activity and quality of life in the elderly: a systematic review, 2000-2012. Rev Bras Psiquiatr. 2014;36(1):76–88.CrossRefPubMed Vagetti GC, Barbosa Filho VC, Moreira NB, Oliveira V, Mazzardo O, Campos W. Association between physical activity and quality of life in the elderly: a systematic review, 2000-2012. Rev Bras Psiquiatr. 2014;36(1):76–88.CrossRefPubMed
47.
go back to reference Unutzer J. Top cited papers in international psychogeriatrics: 2. Quality adjusted life years in older adults with depressive symptoms and chronic medical disorders. Int Psychogeriatr. 2009;21(2):265–6 discussion 6-7.CrossRefPubMed Unutzer J. Top cited papers in international psychogeriatrics: 2. Quality adjusted life years in older adults with depressive symptoms and chronic medical disorders. Int Psychogeriatr. 2009;21(2):265–6 discussion 6-7.CrossRefPubMed
Metadata
Title
Factors related to health-related quality of life in older people with multimorbidity and high health care consumption over a two-year period
Authors
Leonie Klompstra
Anne W. Ekdahl
Barbro Krevers
Anna Milberg
Jeanette Eckerblad
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2019
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-019-1194-z

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