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BMC Geriatrics
Published in: BMC Geriatrics 1/2019

Open Access 01-12-2019 | Research article

Effects of exergame training combined with omega-3 fatty acids on the elderly brain: a randomized double-blind placebo-controlled trial

Authors: Alexandra Schättin, Corinne Baier, Domenique Mai, Verena Klamroth-Marganska, Isabelle Herter-Aeberli, Eling D. de Bruin

Published in: BMC Geriatrics | Issue 1/2019

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Abstract

Background

Older adults often suffer from age- and behavior-related brain changes affecting neuronal functioning and, therefore, cognitive and motor functions. The improvement of these functions might decrease falls and improve mobility. Previous studies indicate that video game-based physical exercise, so-called exergames, or omega-3 fatty acids (FAs) improve motor and cognitive functioning through brain adaptations. The aim of this study was to assess the effects of exergame training combined with fish oil supplementation on neuronal system levels in the brain and behavioral measurements in older adults. We hypothesized that the combination would differently affect these factors compared to the sole administration of exergame.

Methods

Fifty-eight participants were randomly assigned to one of two groups (N = 29 each group) in a parallel, double-blind, randomized controlled trial lasting 26 weeks. The experimental group received daily fish oil, whereas the control group received daily olive oil. After 16 weeks, both groups started with an exergame training. Measurements were performed pre, during, and post intervention. Primary outcomes were recruitment curves using transcranial magnetic stimulation and response-locked potentials using electroencephalography. Secondary outcomes included executive functions and gait parameters. Blood samples were taken to control for FAs.

Results

Forty-three individuals (mean age 69.4 ± 4.6 years) completed the study (Nexperimental = 22, Ncontrol = 21). The results showed no significant time × group interaction effects for any parameters. Blood samples demonstrated significant time × group interaction effects. Post-hoc tests showed a significant increase of omega-3 FAs (p < .001) and a significant decrease of omega-6 FAs (p < .001) for the experimental group.

Conclusion

The combination of exergame training and fish oil did not lead to additional beneficial effects. To trigger possible effects, future studies should carefully consider study design aspects; e.g. study duration, individual nutritional supplementation dose, omega-3 FAs supplementation composition, and placebo. Furthermore, studies should consider neuroimaging methods as these might be more sensitive to assess early brain adaptations. Thus, future studies should be aware of several aspects running a combinatory study that includes omega-3 FAs according to their expected effects.

Trial registration

Swiss National Clinical Trials SNCTP000001623 and ISRCTN12084831 registered 30 November 2015.
Literature
1.
Gunning-Dixon FM, Brickman AM, Cheng JC, Alexopoulos GS. Aging of cerebral white matter: a review of MRI findings. Int J Geriatr Psychiatry. 2009;24(2):109–17.PubMedPubMedCentralCrossRef
2.
Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O'Leary D, Fried L. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996;27(8):1274–82.PubMedCrossRef
3.
Fjell AM, Walhovd KB. Structural brain changes in aging: courses, causes and cognitive consequences. Rev Neurosci. 2010;21(3):187–222.PubMedCrossRef
4.
Backman L, Nyberg L, Lindenberger U, Li SC, Farde L. The correlative triad among aging, dopamine, and cognition: current status and future prospects. Neurosci Biobehav Rev. 2006;30(6):791–807.PubMedCrossRef
5.
Schliebs R, Arendt T. The cholinergic system in aging and neuronal degeneration. Behav Brain Res. 2011;221(2):555–63.PubMedCrossRef
6.
Volkow ND, Gur RC, Wang GJ, Fowler JS, Moberg PJ, Ding YS, Hitzemann R, Smith G, Logan J. Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals. Am J Psychiatry. 1998;155(3):344–9.PubMed
7.
Wang GJ, Volkow ND, Fowler JS, Ding YS, Logan J, Gatley SJ, MacGregor RR, Wolf AP. Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain. Life Sci. 1995;57(14):PL187–91.PubMedCrossRef
8.
Wang Y, Chan GL, Holden JE, Dobko T, Mak E, Schulzer M, Huser JM, Snow BJ, Ruth TJ, Calne DB, et al. Age-dependent decline of dopamine D1 receptors in human brain: a PET study. Synapse. 1998;30(1):56–61.PubMedCrossRef
9.
Banich MT, Mackiewicz KL, Depue BE, Whitmer AJ, Miller GA, Heller W. Cognitive control mechanisms, emotion and memory: a neural perspective with implications for psychopathology. Neurosci Biobehav Rev. 2009;33(5):613–30.PubMedCrossRef
10.
Holtzer R, Verghese J, Xue X, Lipton RB. Cognitive processes related to gait velocity: results from the Einstein Aging Study. Neuropsychology. 2006;20(2):215–23.PubMedCrossRef
11.
Hausdorff JM, Yogev G, Springer S, Simon ES, Giladi N. Walking is more like catching than tapping: gait in the elderly as a complex cognitive task. Exp Brain Res. 2005;164(4):541–8.PubMedCrossRef
12.
Sheridan PL, Solomont J, Kowall N, Hausdorff JM. Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer's disease. J Am Geriatr Soc. 2003;51(11):1633–7.PubMedCrossRef
13.
14.
Rapport LJ, Hanks RA, Millis SR, Deshpande SA. Executive functioning and predictors of falls in the rehabilitation setting. Arch Phys Med Rehabil. 1998;79(6):629–33.PubMedCrossRef
15.
Scherder E, Eggermont L, Visscher C, Scheltens P, Swaab D. Understanding higher level gait disturbances in mild dementia in order to improve rehabilitation: ‘last in-first out’. Neurosci Biobehav Rev. 2011;35(3):699–714.PubMedCrossRef
16.
DeLong MR. Functional and pathophysiological models of the basal ganglia: therapeutic implications. Rinsho Shinkeigaku. 2000;40(12):1184.PubMed
17.
Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord. 2008;23(3):329–42 quiz 472.PubMedCrossRef
18.
Yuan P, Raz N. Prefrontal cortex and executive functions in healthy adults: a meta-analysis of structural neuroimaging studies. Neurosci Biobehav Rev. 2014;42:180–92.PubMedCrossRef
19.
Brickman AM, Zimmerman ME, Paul RH, Grieve SM, Tate DF, Cohen RA, Williams LM, Clark CR, Gordon E. Regional white matter and neuropsychological functioning across the adult lifespan. Biol Psychiatry. 2006;60(5):444–53.PubMedCrossRef
20.
Gunning-Dixon FM, Raz N. Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study. Neuropsychologia. 2003;41(14):1929–41.PubMedCrossRef
21.
Rosano C, Studenski SA, Aizenstein HJ, Boudreau RM, Longstreth WT Jr, Newman AB. Slower gait, slower information processing and smaller prefrontal area in older adults. Age Ageing. 2012;41(1):58–64.PubMedCrossRef
22.
Thompson PD, Nutt JG. Higher level gait disorders. J Neural Transm (Vienna). 2007;114(10):1305–7.CrossRef
23.
Pichierri G, Murer K, de Bruin ED. A cognitive-motor intervention using a dance video game to enhance foot placement accuracy and gait under dual task conditions in older adults: a randomized controlled trial. BMC Geriatr. 2012;12:74.PubMedPubMedCentralCrossRef
24.
Mirelman A, Herman T, Brozgol M, Dorfman M, Sprecher E, Schweiger A, Giladi N, Hausdorff JM. Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition. PloS one. 2012;7(6):e40297.PubMedPubMedCentralCrossRef
25.
de Bruin ED, Reith A, Dorflinger M, Murer K. Feasibility of strength-balance training extended with computer game dancing in older people; does it affect dual task costs of walking? J Novel Physiotherapies. 2011;1:104.CrossRef
26.
de Bruin ED, van Het Reve E, Murer K. A randomized controlled pilot study assessing the feasibility of combined motor–cognitive training and its effect on gait characteristics in the elderly. Clin Rehab. 2013;27(3):215–25.CrossRef
27.
Pichierri G, Coppe A, Lorenzetti S, Murer K, de Bruin ED. The effect of a cognitive-motor intervention on voluntary step execution under single and dual task conditions in older adults: a randomized controlled pilot study. Clin Interv Aging. 2012;7:175–84.PubMedPubMedCentralCrossRef
28.
Bamidis P, Vivas A, Styliadis C, Frantzidis C, Klados M, Schlee W, Siountas A, Papageorgiou S. A review of physical and cognitive interventions in aging. Neurosci Biobehav Rev. 2014;44:206–20.PubMedCrossRef
29.
Segev-Jacubovski O, Herman T, Yogev-Seligmann G, Mirelman A, Giladi N, Hausdorff JM. The interplay between gait, falls and cognition: can cognitive therapy reduce fall risk? Expert Rev Neurother. 2011;11(7):1057–75.PubMedPubMedCentralCrossRef
30.
Law LL, Barnett F, Yau MK, Gray MA. Effects of combined cognitive and exercise interventions on cognition in older adults with and without cognitive impairment: a systematic review. Ageing Res Rev. 2014;15:61–75.PubMedCrossRef
31.
Curlik DM 2nd, Shors TJ. Training your brain: Do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus? Neuropharmacology. 2013;64:506–14.PubMedCrossRef
32.
Fissler P, Kuster O, Schlee W, Kolassa IT. Novelty interventions to enhance broad cognitive abilities and prevent dementia: synergistic approaches for the facilitation of positive plastic change. Prog Brain Res. 2013;207:403–34.PubMedCrossRef
33.
34.
Toril P, Reales JM, Ballesteros S. Video game training enhances cognition of older adults: a meta-analytic study. Psychol Aging. 2014;29(3):706–16.PubMedCrossRef
35.
Zelinski EM, Reyes R. Cognitive benefits of computer games for older adults. Gerontechnology. 2009;8:4.CrossRef
36.
Yan JH, Zhou CL. Effects of motor practice on cognitive disorders in older adults. Eur Rev Aging Phys A. 2009;6(2):67–74.CrossRef
37.
Eggenberger P, Wolf M, Schumann M, de Bruin ED. Exergame and Balance Training Modulate Prefrontal Brain Activity during Walking and Enhance Executive Function in Older Adults. Front Aging Neurosci. 2016;8:66.PubMedPubMedCentralCrossRef
38.
Schättin A, Arner R, Gennaro F, de Bruin E. Adaptations of prefrontal brain activity, executive functions, and gait in healthy elderly following exergame and balance training: A randomized-controlled study. Front Aging Neurosci. 2016;8:278.PubMedPubMedCentral
39.
Stanmore E, Stubbs B, Vancampfort D, de Bruin ED, Firth J. The effect of active video games on cognitive functioning in clinical and non-clinical populations: A meta-analysis of randomized controlled trials. Neurosci Biobehav Rev. 2017;78:34–43.PubMedCrossRef
40.
41.
42.
43.
44.
Pinilla FG. The impact of diet and exercise on brain plasticity and disease. Nutr Health. 2006;18(3):277–84.PubMedCrossRef
45.
Schattin A, Baur K, Stutz J, Wolf P, de Bruin ED. Effects of Physical Exercise Combined with Nutritional Supplements on Aging Brain Related Structures and Functions: A Systematic Review. Front Aging Neurosci. 2016;8:161.PubMedPubMedCentral
46.
Janssen CI, Kiliaan AJ. Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: the influence of LCPUFA on neural development, aging, and neurodegeneration. Prog Lipid Res. 2014;53:1–17.PubMedCrossRef
47.
48.
Haast RA, Kiliaan AJ. Impact of fatty acids on brain circulation, structure and function. Prostaglandins Leukot Essent Fatty Acids (PLEFA). 2015;92:3–14.CrossRef
49.
Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neurosci. 2008;155(3):751–9.CrossRef
50.
Witte AV, Kerti L, Hermannstädter HM, Fiebach JB, Schreiber SJ, Schuchardt JP, Hahn A, Flöel A. Long-chain omega-3 fatty acids improve brain function and structure in older adults. Cereb Cortex. 2014;24(11):3059–68.PubMedCrossRef
51.
Nilsson A, Radeborg K, Salo I, Bjorck I. Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study. Nutr J. 2012;11:99.PubMedPubMedCentralCrossRef
52.
Chytrova G, Ying Z, Gomez-Pinilla F. Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems. Brain Res. 2010;1341:32–40.PubMedCrossRef
53.
Schättin A, de Bruin ED. Combining Exergame Training with Omega-3 Fatty Acid Supplementation: Protocol for a Randomized Controlled Study Assessing the Effect on Neuronal Structure/Function in the Elderly Brain. Front Aging Neurosci. 2016;8:283.PubMedPubMedCentral
54.
Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P. Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med. 2008;148(4):295–309.PubMedCrossRef
55.
56.
MacKenzie D, Copp P, Shaw R, Goodwin G. Brief cognitive screening of the elderly: a comparison of the mini-mental state examination (MMSE), abbreviated mental test (AMT) and mental status questionnaire (MSQ). Psychol Med. 1996;26(2):427–30.PubMedCrossRef
57.
Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D, Altman DG, Barbour V, Macdonald H, Johnston M. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. Bmj. 2014;348:g1687.PubMedCrossRef
58.
Miller PE, Van Elswyk M, Alexander DD. Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a meta-analysis of randomized controlled trials. Am J Hypertens. 2014;27(7):885–96.PubMedPubMedCentralCrossRef
59.
Cacchio A, Cimini N, Alosi P, Santilli V, Marrelli A. Reliability of transcranial magnetic stimulation-related measurements of tibialis anterior muscle in healthy subjects. Clin Neurophysiol. 2009;120(2):414–9.PubMedCrossRef
60.
Möller C, Arai N, Lücke J, Ziemann U. Hysteresis effects on the input–output curve of motor evoked potentials. Clin Neurophysiol. 2009;120(5):1003–8.PubMedCrossRef
61.
Ruffini G, Dunne S, Farrés E, Cester I, Watts PC, Ravi S, Silva P, Grau C, Fuentemilla L, Marco-Pallares J. ENOBIO dry electrophysiology electrode; first human trial plus wireless electrode system. In: Engineering in Medicine and Biology Society, 2007 EMBS 2007 29th Annual International Conference of the IEEE; 2007. p. 6689–93.CrossRef
62.
Ruffini G, Dunne S, Farres E, Watts PC, Mendoza E, Silva SRP, Grau C, Marco-Pallares J, Fuentemilla L, Vandecasteele B. Enobio-first tests of a dry electrophysiology electrode using carbon nanotubes. In: Engineering in Medicine and Biology Society, 2006 EMBS’06 28th Annual International Conference of the IEEE; 2006. p. 1826–9.CrossRef
63.
64.
Gehring WJ, Knight RT. Prefrontal-cingulate interactions in action monitoring. Nat Neurosci. 2000;3(5):516–20.PubMedCrossRef
65.
Delorme A, Makeig S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods. 2004;134(1):9–21.PubMedCrossRef
66.
67.
Themanson JR, Hillman CH. Cardiorespiratory fitness and acute aerobic exercise effects on neuroelectric and behavioral measures of action monitoring. Neurosci. 2006;141(2):757–67.CrossRef
68.
Cid-Fernandez S, Lindin M, Diaz F. Information processing becomes slower and predominantly serial in aging: Characterization of response-related brain potentials in an auditory-visual distraction-attention task. Biol Psychol. 2016;113:12–23.PubMedCrossRef
69.
Luck SJ. An Introduction to the Event-Related Potential Technique, 2 edn: MIT Press; 2014.
70.
Zimmermann P, Fimm B. A test battery for attentional performance. Applied neuropsychology of attention Theory, diagnosis and rehabilitation; 2002. p. 110–51.
71.
Aminian K, Robert P, Buchser EE, Rutschmann B, Hayoz D, Depairon M. Physical activity monitoring based on accelerometry: validation and comparison with video observation. Med Biol Eng Comput. 1999;37(3):304–8.PubMedCrossRef
72.
de Bruin ED, Najafi B, Murer K, Uebelhart D, Aminian K. Quantification of everyday motor function in a geriatric population. J Rehab Res Dev. 2007;44(3):417–28.CrossRef
73.
Dubost V, Kressig RW, Gonthier R, Herrmann FR, Aminian K, Najafi B, Beauchet O. Relationships between dual-task related changes in stride velocity and stride time variability in healthy older adults. Hum Mov Sci. 2006;25(3):372–82.PubMedCrossRef
74.
Mariani B, Rochat S, Bula CJ, Aminian K. Heel and toe clearance estimation for gait analysis using wireless inertial sensors. IEEE Trans Biomed Eng. 2012;59(11):3162–8.PubMedCrossRef
75.
McDowd JM. The effects of age and extended practice on divided attention performance. J Gerontol. 1986;41(6):764–9.PubMedCrossRef
76.
Harris WS, Von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med. 2004;39(1):212–20.PubMedCrossRef
77.
Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.PubMedCrossRef
78.
Tombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40(9):922–35.PubMedCrossRef
79.
Yesavage JA, Brink T, Rose TL, Lum O, Huang V, Adey M, Leirer VO. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatric Res. 1983;17(1):37–49.CrossRef
80.
Yesavage JA, Sheikh JI. 9/Geriatric Depression Scale (GDS) Recent Evidence and Development of a Shorter Violence. Clin Gerontol. 1986;5(1–2):165–73.CrossRef
81.
Kempen GI, Yardley L, van Haastregt JC, Zijlstra GA, Beyer N, Hauer K, Todd C. The Short FES-I: a shortened version of the falls efficacy scale-international to assess fear of falling. Age Ageing. 2008;37(1):45–50.PubMedCrossRef
82.
Thomas JR, Nelson JK, Thomas KT. A generalized rank-order method for nonparametric analysis of data from exercise science: a tutorial. Res Q Exerc Sport. 1999;70(1):11–23.PubMedCrossRef
83.
Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013;4:863.PubMedPubMedCentralCrossRef
84.
Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. Consolidated Standards of Reporting Trials G: CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol. 2010;63(8):e1–37.PubMedCrossRef
85.
Phillips C. Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging. Neural Plast. 2017;2017:3589271.PubMedPubMedCentral
86.
Kobe T, Witte AV, Schnelle A, Lesemann A, Fabian S, Tesky VA, Pantel J, Floel A. Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. Neuroimage. 2016;131:226–38.PubMedCrossRef
87.
Beaudart C, Dawson A, Shaw SC, Harvey NC, Kanis JA, Binkley N, Reginster JY, Chapurlat R, Chan DC, Bruyere O, et al. Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review. Osteoporos Int. 2017;28(6):1817–33.PubMedPubMedCentralCrossRef
88.
Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006;83(6 Suppl):1467S–76S.PubMedCrossRef
89.
Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res. 1997;38(10):2012–22.PubMed
90.
Stonehouse W. Does Consumption of LC Omega-3 PUFA Enhance Cognitive Performance in Healthy School-Aged Children and throughout Adulthood? Evidence from Clinical Trials. Nutrients. 2014;6(7):2730–58.PubMedPubMedCentralCrossRef
91.
Harris WS. The omega-3 index: clinical utility for therapeutic intervention. Curr Cardiol Rep. 2010;12(6):503–8.PubMedCrossRef
92.
Chilton FH, Dutta R, Reynolds LM, Sergeant S, Mathias RA, Seeds MC. Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. Nutrients. 2017;9:11.CrossRef
93.
Dyall SC. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Front Aging Neurosci. 2015;7:52.PubMedPubMedCentralCrossRef
94.
Brenna JT, Diau GY. The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. Prostaglandins Leukot Essent Fatty Acids. 2007;77(5–6):247–50.PubMedPubMedCentralCrossRef
95.
Piroddi M, Albini A, Fabiani R, Giovannelli L, Luceri C, Natella F, Rosignoli P, Rossi T, Taticchi A, Servili M, et al. Nutrigenomics of extra-virgin olive oil: A review. Biofactors. 2017;43(1):17–41.PubMedCrossRef
96.
Tian Q, Chastan N, Bair WN, Resnick SM, Ferrucci L, Studenski SA. The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review. Neurosci Biobehav Rev. 2017;74(Pt A):149–62.PubMedPubMedCentralCrossRef
Metadata
Title
Effects of exergame training combined with omega-3 fatty acids on the elderly brain: a randomized double-blind placebo-controlled trial
Authors
Alexandra Schättin
Corinne Baier
Domenique Mai
Verena Klamroth-Marganska
Isabelle Herter-Aeberli
Eling D. de Bruin
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2019
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-019-1084-4

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