Skip to main content
Top
Published in: BMC Geriatrics 1/2019

Open Access 01-12-2019 | Care | Research article

Pharmacist-led medication reviews for geriatric residents in German long-term care facilities

Authors: Kerstin Bitter, Christina Pehe, Manfred Krüger, Gabriela Heuer, Regine Quinke, Ulrich Jaehde

Published in: BMC Geriatrics | Issue 1/2019

Login to get access

Abstract

Background

The benefit of medication reviews for long-term care (LTC) residents has been generally recognized throughout health care systems. Whereas many studies showed the impact of comprehensive medication reviews performed by specialized clinical pharmacists, little is known about the impact of medication reviews performed by community pharmacists. Involving them in the provision of medication reviews may help satisfy the increasing demand for ensuring medication safety.

Methods

Community pharmacists supplying drugs to the LTC facilities performed a medication review for German LTC residents aged at least 65 years and taking five or more drugs per day based on the patients’ medication only. Documented potential drug-related problems (DRPs) and the implementation rate of pharmaceutical interventions were evaluated descriptively. To assess the quality of the medication reviews, we developed a corresponding reference system based on the analysis of two experienced clinical pharmacists.

Results

Twelve pharmacies performed medication reviews for 94 LTC residents. Overall, the pharmacists documented 154 potential DRPs (mean 1.6 per patient, SD 1.5) of which the most common were drug-drug interactions (40%) followed by potentially inappropriate medication (PIM) (16%) and inappropriate dosages (14%). 33% of the pharmacists’ interventions to solve DRPs were successfully implemented, mostly dosage adjustments. The identification of potentially severe drug-drug interactions and PIM showed the highest agreement (88 and 73%) with the reference system.

Conclusions

The medication review program of community pharmacists for LTC residents led to the identification of relevant DRPs. The reference system assessing the quality of the service can contribute to its transparency and reveals the potential for its improvement. The community pharmacists’ knowledge of the LTC residents and their relation to the prescribers is crucial for providing successful medication reviews.
Literature
1.
go back to reference Hersberger K, Griese-Mammen N, Kos M, Horvat N, Messerli M, van Mil F. Position Paper on the PCNE definition of Medication Review http://www.pcne.org. Accessed 4 Aug 2018. Hersberger K, Griese-Mammen N, Kos M, Horvat N, Messerli M, van Mil F. Position Paper on the PCNE definition of Medication Review http://​www.​pcne.​org. Accessed 4 Aug 2018.
3.
go back to reference Duijmelinck D, van de Ven W. What can Europe learn from the managed care backlash in the United States? Health Policy. 2016;120:509–18.CrossRef Duijmelinck D, van de Ven W. What can Europe learn from the managed care backlash in the United States? Health Policy. 2016;120:509–18.CrossRef
4.
go back to reference Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, Hughes CM. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5:e009235.CrossRef Cooper JA, Cadogan CA, Patterson SM, Kerse N, Bradley MC, Ryan C, Hughes CM. Interventions to improve the appropriate use of polypharmacy in older people: a Cochrane systematic review. BMJ Open. 2015;5:e009235.CrossRef
5.
go back to reference Vinks T, Egberts T, de Lange T, de Koning F. Pharmacist-based medication review reduces potential drug-related problems in the elderly. Drugs Aging. 2009;26:123–33.CrossRef Vinks T, Egberts T, de Lange T, de Koning F. Pharmacist-based medication review reduces potential drug-related problems in the elderly. Drugs Aging. 2009;26:123–33.CrossRef
6.
go back to reference Huiskes VJ, Burger DM, van den Ende CH, van den Bemt BJ. Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials. BMC Fam Pract. 2017;18:5.CrossRef Huiskes VJ, Burger DM, van den Ende CH, van den Bemt BJ. Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials. BMC Fam Pract. 2017;18:5.CrossRef
7.
go back to reference Meid AD, Lampert A, Burnett A, Seidling HM, Haefeli WE. The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis. Br J Clin Pharmacol. 2015;80:768–76.CrossRef Meid AD, Lampert A, Burnett A, Seidling HM, Haefeli WE. The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis. Br J Clin Pharmacol. 2015;80:768–76.CrossRef
8.
go back to reference Seidling HM, Send AFJ, Bittmann J, Renner K, Dewald B, Lange D, et al. Medication review in German community pharmacies - post-hoc analysis of documented drug-related problems and subsequent interventions in the ATHINA-project. Res Social Adm Pharm. 2017;13:1127–34. Seidling HM, Send AFJ, Bittmann J, Renner K, Dewald B, Lange D, et al. Medication review in German community pharmacies - post-hoc analysis of documented drug-related problems and subsequent interventions in the ATHINA-project. Res Social Adm Pharm. 2017;13:1127–34.
9.
go back to reference Gurwitz JH, Field TS, Judge J, Rochon P, Harrold LR, Cadoret C, et al. The incidence of adverse drug events in two large academic long-term care facilities. Am J Med. 2005;118:251–8.CrossRef Gurwitz JH, Field TS, Judge J, Rochon P, Harrold LR, Cadoret C, et al. The incidence of adverse drug events in two large academic long-term care facilities. Am J Med. 2005;118:251–8.CrossRef
11.
go back to reference O'Shea TE, Zarowitz BJ, Erwin WG. Comprehensive medication reviews in long-term care facilities: history of process implementation and 2015 results. J Manag Care Spec Pharm. 2017;23:22–6.PubMed O'Shea TE, Zarowitz BJ, Erwin WG. Comprehensive medication reviews in long-term care facilities: history of process implementation and 2015 results. J Manag Care Spec Pharm. 2017;23:22–6.PubMed
13.
go back to reference Holt S, Schmiedl S, Thurmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int. 2010;107:543–51.PubMedPubMedCentral Holt S, Schmiedl S, Thurmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int. 2010;107:543–51.PubMedPubMedCentral
14.
go back to reference The American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 2015;63:2227–46. The American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc 2015;63:2227–46.
16.
go back to reference Chau SH, Jansen APD, van de Ven, Peter M, Hoogland P, Elders PJM, Hugtenburg JG. Clinical medication reviews in elderly patients with polypharmacy: a cross-sectional study on drug-related problems in the Netherlands. Int J Clin Pharm. 2016;38:46–53.CrossRef Chau SH, Jansen APD, van de Ven, Peter M, Hoogland P, Elders PJM, Hugtenburg JG. Clinical medication reviews in elderly patients with polypharmacy: a cross-sectional study on drug-related problems in the Netherlands. Int J Clin Pharm. 2016;38:46–53.CrossRef
17.
go back to reference Finkers F, Maring JG, Boersma F, Taxis K. A study of medication reviews to identify drug-related problems of polypharmacy patients in the Dutch nursing home setting. J Clin Pharm Ther. 2007;32:469–76.CrossRef Finkers F, Maring JG, Boersma F, Taxis K. A study of medication reviews to identify drug-related problems of polypharmacy patients in the Dutch nursing home setting. J Clin Pharm Ther. 2007;32:469–76.CrossRef
18.
go back to reference Gheewala PA, Peterson GM, Curtain CM, Nishtala PS, Hannan PJ, Castelino RL. Impact of the pharmacist medication review services on drug-related problems and potentially inappropriate prescribing of renally cleared medications in residents of aged care facilities. Drugs Aging. 2014;31:825–35.CrossRef Gheewala PA, Peterson GM, Curtain CM, Nishtala PS, Hannan PJ, Castelino RL. Impact of the pharmacist medication review services on drug-related problems and potentially inappropriate prescribing of renally cleared medications in residents of aged care facilities. Drugs Aging. 2014;31:825–35.CrossRef
19.
go back to reference Sewell MJ, Riche DM, Fleming JW, Malinowski SS, Jackson RT. Comparison of pharmacist and physician managed annual Medicare wellness services. J Manag Care Spec Pharm. 2016;22:1412–6.PubMed Sewell MJ, Riche DM, Fleming JW, Malinowski SS, Jackson RT. Comparison of pharmacist and physician managed annual Medicare wellness services. J Manag Care Spec Pharm. 2016;22:1412–6.PubMed
20.
go back to reference Bryant LJM, Coster G, Gamble GD, McCormick RN. The general practitioner-pharmacist collaboration (GPPC) study: a randomised controlled trial of clinical medication reviews in community pharmacy. Int J Pharm Pract. 2011;19:94–105.CrossRef Bryant LJM, Coster G, Gamble GD, McCormick RN. The general practitioner-pharmacist collaboration (GPPC) study: a randomised controlled trial of clinical medication reviews in community pharmacy. Int J Pharm Pract. 2011;19:94–105.CrossRef
21.
go back to reference Hurkens KPGM, Mestres-Gonzalvo C, de Wit HAJM, van der Kuy PHM, Janknegt R, Verhey F, et al. Usually available clinical and laboratory data are insufficient for a valid medication review: a crossover study. J Nutr Health Aging. 2016;20:71–6.CrossRef Hurkens KPGM, Mestres-Gonzalvo C, de Wit HAJM, van der Kuy PHM, Janknegt R, Verhey F, et al. Usually available clinical and laboratory data are insufficient for a valid medication review: a crossover study. J Nutr Health Aging. 2016;20:71–6.CrossRef
22.
go back to reference Zillich AJ, McDonough RP, Carter BL, Doucette WR. Influential characteristics of physician/pharmacist collaborative relationships. Ann Pharmacother. 2004;38:764–70.CrossRef Zillich AJ, McDonough RP, Carter BL, Doucette WR. Influential characteristics of physician/pharmacist collaborative relationships. Ann Pharmacother. 2004;38:764–70.CrossRef
23.
go back to reference Alkhateeb FM, Clauson KA, McCafferty R, Latif DA. Physician attitudes toward pharmacist provision of medication therapy management services. Pharm World Sci. 2009;31:487–93.CrossRef Alkhateeb FM, Clauson KA, McCafferty R, Latif DA. Physician attitudes toward pharmacist provision of medication therapy management services. Pharm World Sci. 2009;31:487–93.CrossRef
24.
go back to reference Van C, Costa D, Abbott P, Mitchell B, Krass I. Community pharmacist attitudes towards collaboration with general practitioners: development and validation of a measure and a model. BMC Health Serv Res. 2012;12:320.CrossRef Van C, Costa D, Abbott P, Mitchell B, Krass I. Community pharmacist attitudes towards collaboration with general practitioners: development and validation of a measure and a model. BMC Health Serv Res. 2012;12:320.CrossRef
25.
go back to reference Doucette WR, Nevins J, McDonough RP. Factors affecting collaborative care between pharmacists and physicians. Res Social Adm Pharm. 2005;1:565–78.CrossRef Doucette WR, Nevins J, McDonough RP. Factors affecting collaborative care between pharmacists and physicians. Res Social Adm Pharm. 2005;1:565–78.CrossRef
26.
go back to reference Laaksonen R, Duggan C, Bates I. Performance of community pharmacists in providing clinical medication reviews. Ann Pharmacother. 2010;44:1181–90.CrossRef Laaksonen R, Duggan C, Bates I. Performance of community pharmacists in providing clinical medication reviews. Ann Pharmacother. 2010;44:1181–90.CrossRef
27.
go back to reference Krska J, Avery AJ. Evaluation of medication reviews conducted by community pharmacists: a quantitative analysis of documented issues and recommendations. Br J Clin Pharmacol. 2008;65:386–96.CrossRef Krska J, Avery AJ. Evaluation of medication reviews conducted by community pharmacists: a quantitative analysis of documented issues and recommendations. Br J Clin Pharmacol. 2008;65:386–96.CrossRef
28.
go back to reference Kwint HF, Faber A, Gussekloo J, Bouvy ML. Completeness of medication reviews provided by community pharmacists. J Clin Pharm Ther. 2014;39:248–52.CrossRef Kwint HF, Faber A, Gussekloo J, Bouvy ML. Completeness of medication reviews provided by community pharmacists. J Clin Pharm Ther. 2014;39:248–52.CrossRef
29.
go back to reference Greissing C, Kossler K, Freyer J, Huter L, Buchal P, Schiek S, Bertsche T. The status of the performance of medication reviews in German community pharmacies and assessment of the practical performance. Int J Clin Pharm. 2016;38:1425–35.CrossRef Greissing C, Kossler K, Freyer J, Huter L, Buchal P, Schiek S, Bertsche T. The status of the performance of medication reviews in German community pharmacies and assessment of the practical performance. Int J Clin Pharm. 2016;38:1425–35.CrossRef
Metadata
Title
Pharmacist-led medication reviews for geriatric residents in German long-term care facilities
Authors
Kerstin Bitter
Christina Pehe
Manfred Krüger
Gabriela Heuer
Regine Quinke
Ulrich Jaehde
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Care
Published in
BMC Geriatrics / Issue 1/2019
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-019-1052-z

Other articles of this Issue 1/2019

BMC Geriatrics 1/2019 Go to the issue