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Published in: BMC Geriatrics 1/2018

Open Access 01-12-2018 | Research article

The frail older person does not exist: development of frailty profiles with latent class analysis

Authors: W. M. Looman, I. N. Fabbricotti, J. W. Blom, A. P. D. Jansen, J. E. Lutomski, S. F. Metzelthin, R. Huijsman, on behalf of the TOPICS-MDS Research Consortium

Published in: BMC Geriatrics | Issue 1/2018

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Abstract

Background

A fundamental issue in elderly care is targeting those older people at risk and in need of care interventions. Frailty is widely used to capture variations in health risks but there is no general consensus on the conceptualization of frailty. Indeed, there is considerable heterogeneity in the group of older people characterized as frail. This research identifies frailty profiles based on the physical, psychological, social and cognitive domains of functioning and the severity of the problems within these domains.

Methods

This research was a secondary data-analysis of older persons derived from The Older Person and Informal Caregiver Minimum Dataset. Selected respondents were 60 years and older (n = 43,704; 59.6% female). The following variables were included: self-reported health, cognitive functioning, social functioning, mental health, morbidity status, and functional limitations. Using latent class analysis, the population was divided in subpopulations that were subsequently discussed in a focus group with older people for further validation.

Results

We distinguished six frailty profiles: relatively healthy; mild physically frail; psychologically frail; severe physically frail; medically frail and multi-frail. The relatively healthy had limited problems across all domains. In three profiles older people mostly had singular problems in either the physical or psychological domain and the severity of the problems differed. Two remaining profiles were multidimensional with a combination of problems that extended to the social and cognitive domains.

Conclusions

Our research provides an empirical base for meaningful frailty profiles. The profiles showed specific patterns underlying the problems in different domains of functioning. The heterogeneous population of frail older people has differing needs and faces different health issues that should be considered to tailor care interventions. Evaluation research of these interventions should acknowledge the heterogeneity of frailty by profiling.
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Literature
1.
go back to reference United Nations, Department of Economic and Social Affairs, Populations Division: World Population Ageing 2015. 2015, (ST/ESA/SER.A/390):. United Nations, Department of Economic and Social Affairs, Populations Division: World Population Ageing 2015. 2015, (ST/ESA/SER.A/390):.
2.
go back to reference World Health Organization: World report on ageing and health. Geneva: WHO. ISBN: 978 924 156504 2. World Health Organization: World report on ageing and health. Geneva: WHO. ISBN: 978 924 156504 2.
3.
go back to reference Rockwood K, Fox RA, Stolee P, Robertson D, Beattie L. Frailty in elderly people: an evolving concept. CMAJ. 1994;150(4):489–95.PubMedPubMedCentral Rockwood K, Fox RA, Stolee P, Robertson D, Beattie L. Frailty in elderly people: an evolving concept. CMAJ. 1994;150(4):489–95.PubMedPubMedCentral
5.
go back to reference Schuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JP. Old or frail: what tells us more? J Gerontol Ser A Biol Med Sci. 2004;59(9):M962–5.CrossRef Schuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JP. Old or frail: what tells us more? J Gerontol Ser A Biol Med Sci. 2004;59(9):M962–5.CrossRef
6.
go back to reference Van Kempen JAL, Schers HJ, Jacobs A, Zuidema SU, Ruikes F, Robben SHM, RJF M, Olde Rikkert MGM. Development of an instrument for the identification of frail older people as a target population for integrated care. Br J Gen Pract. 2013;63:e225–31.CrossRefPubMedPubMedCentral Van Kempen JAL, Schers HJ, Jacobs A, Zuidema SU, Ruikes F, Robben SHM, RJF M, Olde Rikkert MGM. Development of an instrument for the identification of frail older people as a target population for integrated care. Br J Gen Pract. 2013;63:e225–31.CrossRefPubMedPubMedCentral
7.
go back to reference Lacas A, Rockwood K. Frailty in primary care: a review of its conceptualization and implications for practice. BMC Med. 2012, Jan;11(10):4.CrossRef Lacas A, Rockwood K. Frailty in primary care: a review of its conceptualization and implications for practice. BMC Med. 2012, Jan;11(10):4.CrossRef
8.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA, Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRefPubMed Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA, Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRefPubMed
9.
go back to reference Gobbens R, Luijkx K, Wijnen-Sponselee MT, Schols J. Towards an integral conceptual model of frailty. J Nutr Health Aging. 2010;14(3):175–81.CrossRefPubMed Gobbens R, Luijkx K, Wijnen-Sponselee MT, Schols J. Towards an integral conceptual model of frailty. J Nutr Health Aging. 2010;14(3):175–81.CrossRefPubMed
10.
go back to reference Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed
11.
go back to reference Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3–10.CrossRefPubMed Dent E, Kowal P, Hoogendijk EO. Frailty measurement in research and clinical practice: a review. Eur J Intern Med. 2016;31:3–10.CrossRefPubMed
12.
go back to reference Manthorpe J, Iliffe S. Frailty – from bedside to buzzword? J Integrated Care. 2015;23(3):120–8.CrossRef Manthorpe J, Iliffe S. Frailty – from bedside to buzzword? J Integrated Care. 2015;23(3):120–8.CrossRef
13.
go back to reference Markle-Reid M, Browne G. Conceptualizations of frailty in relation to older adults. J Adv Nurs. 2003;44:58–68.CrossRefPubMed Markle-Reid M, Browne G. Conceptualizations of frailty in relation to older adults. J Adv Nurs. 2003;44:58–68.CrossRefPubMed
15.
go back to reference Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol Ser A Biol Med Sci. 2007;62(7):722–7.CrossRef Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol Ser A Biol Med Sci. 2007;62(7):722–7.CrossRef
16.
go back to reference Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.CrossRefPubMedPubMedCentral Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.CrossRefPubMedPubMedCentral
17.
go back to reference Metzelthin SF, Daniëls R, van Rossum E, de Witte L, van den Heuvel WJA, Kempen GI. The psychometric properties of three self-report screening instruments for identifying frail older people in the community. BMC Public Health. 2010;10(1):176.CrossRefPubMedPubMedCentral Metzelthin SF, Daniëls R, van Rossum E, de Witte L, van den Heuvel WJA, Kempen GI. The psychometric properties of three self-report screening instruments for identifying frail older people in the community. BMC Public Health. 2010;10(1):176.CrossRefPubMedPubMedCentral
18.
go back to reference Eklund K, Wilhelmson K. Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomized controlled trails. Health Soc Care Community. 2009;17(5):447–58 Eklund K, Wilhelmson K. Outcomes of coordinated and integrated interventions targeting frail elderly people: a systematic review of randomized controlled trails. Health Soc Care Community. 2009;17(5):447–58
19.
go back to reference Newcomer SR, Steiner JF, Bayliss EA. Identifying subgroups of complex patients with cluster analysis. Am J Manag Care. 2011;17(8):e324–32.PubMed Newcomer SR, Steiner JF, Bayliss EA. Identifying subgroups of complex patients with cluster analysis. Am J Manag Care. 2011;17(8):e324–32.PubMed
20.
go back to reference Olaya B, Moneta MV, Caballero FF, Tyrovolas S, Bayes I, Ayuso-Mateos JL, Haro JM. Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study. BMC Geriatr. 2017;17(1):186.CrossRefPubMedPubMedCentral Olaya B, Moneta MV, Caballero FF, Tyrovolas S, Bayes I, Ayuso-Mateos JL, Haro JM. Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study. BMC Geriatr. 2017;17(1):186.CrossRefPubMedPubMedCentral
21.
22.
go back to reference Liu LF, Tian WH, Yao HP. The heterogeneous health latent classes of elderly people and their socio-demographic characteristics in Taiwan. Arch Gerontol Geriatr. 2014;58:205–13.CrossRefPubMed Liu LF, Tian WH, Yao HP. The heterogeneous health latent classes of elderly people and their socio-demographic characteristics in Taiwan. Arch Gerontol Geriatr. 2014;58:205–13.CrossRefPubMed
23.
go back to reference Liu L, Guo C, Lee W, Chen L, Hwang A, Lin M, Peng L, Chen L, Liang K. Subtypes of physical frailty: latent class analysis and associations with clinical characteristics and outcomes. Sci Rep. 2017;7:46417.CrossRefPubMedPubMedCentral Liu L, Guo C, Lee W, Chen L, Hwang A, Lin M, Peng L, Chen L, Liang K. Subtypes of physical frailty: latent class analysis and associations with clinical characteristics and outcomes. Sci Rep. 2017;7:46417.CrossRefPubMedPubMedCentral
24.
go back to reference Lutomski JE, Baars MAE, Schalk BWM, Boter H, Buurman BM, den Elzen WPJ, Jansen APD, Kempen G, Steunenberg B, Steyerberg EW, Rikkert M, Melis RJF. The development of the older persons and informal caregivers survey minimum DataSet (TOPICS-MDS): a large-scale data sharing initiative. PLoS One. 2013;8(12):e81673.CrossRefPubMedPubMedCentral Lutomski JE, Baars MAE, Schalk BWM, Boter H, Buurman BM, den Elzen WPJ, Jansen APD, Kempen G, Steunenberg B, Steyerberg EW, Rikkert M, Melis RJF. The development of the older persons and informal caregivers survey minimum DataSet (TOPICS-MDS): a large-scale data sharing initiative. PLoS One. 2013;8(12):e81673.CrossRefPubMedPubMedCentral
25.
go back to reference Van der Zee K, Sanderman R: RAND-36. Groningen: Northern Centre for Health Care Research, University of Groningen, the Netherlands 1993, 28. Van der Zee K, Sanderman R: RAND-36. Groningen: Northern Centre for Health Care Research, University of Groningen, the Netherlands 1993, 28.
26.
go back to reference Krabbe PF, Stouthard ME, Essink-Bot M, Bonsel GJ. The effect of adding a cognitive dimension to the EuroQol multiattribute health-status classification system. J Clin Epidemiol. 1999;52(4):293–301.CrossRefPubMed Krabbe PF, Stouthard ME, Essink-Bot M, Bonsel GJ. The effect of adding a cognitive dimension to the EuroQol multiattribute health-status classification system. J Clin Epidemiol. 1999;52(4):293–301.CrossRefPubMed
27.
go back to reference Laan W, Zuithoff A, Drubbel I, Bleijenberg N, Numans M, De Wit N, Schuurmans M. Validity and reliability of the Katz-15 scale to measure unfavorable health outcomes in community-dwelling older people. J Nutr Health Aging. 2014;18(9):848.CrossRefPubMed Laan W, Zuithoff A, Drubbel I, Bleijenberg N, Numans M, De Wit N, Schuurmans M. Validity and reliability of the Katz-15 scale to measure unfavorable health outcomes in community-dwelling older people. J Nutr Health Aging. 2014;18(9):848.CrossRefPubMed
28.
go back to reference Weinberger M, Samsa GP, Schmader K, Greenberg SM, Carr DB, Wildman DS. Comparing proxy and patients’ perceptions of patients’ functional status: results from an outpatient geriatric clinic. J Am Geriatr Soc. 1992;40(6):585–8.CrossRefPubMed Weinberger M, Samsa GP, Schmader K, Greenberg SM, Carr DB, Wildman DS. Comparing proxy and patients’ perceptions of patients’ functional status: results from an outpatient geriatric clinic. J Am Geriatr Soc. 1992;40(6):585–8.CrossRefPubMed
29.
go back to reference Lutomski JE, Baars MA, Kempen JA, Buurman BM, Elzen WP, Jansen AP, Kempen GI, Krabbe PF, Steunenberg B, Steyerberg EW. Validation of a frailty index from the older persons and informal caregivers survey minimum data set. J Am Geriatr Soc. 2013;61(9):1625–7.CrossRefPubMed Lutomski JE, Baars MA, Kempen JA, Buurman BM, Elzen WP, Jansen AP, Kempen GI, Krabbe PF, Steunenberg B, Steyerberg EW. Validation of a frailty index from the older persons and informal caregivers survey minimum data set. J Am Geriatr Soc. 2013;61(9):1625–7.CrossRefPubMed
31.
go back to reference Muthén B, Muthén LK. Integrating person-centered and variable-centered analyses: growth mixture modeling with latent trajectory classes. Alcohol Clin Exp Res. 2000;24(6):882–91.CrossRefPubMed Muthén B, Muthén LK. Integrating person-centered and variable-centered analyses: growth mixture modeling with latent trajectory classes. Alcohol Clin Exp Res. 2000;24(6):882–91.CrossRefPubMed
32.
go back to reference Geiser C: Data analysis with Mplus: Guilford press; 2012. Geiser C: Data analysis with Mplus: Guilford press; 2012.
33.
go back to reference Hagenaars JA, McCutcheon AL. Applied latent class analysis. Cambridge: Cambridge University Press; 2002.CrossRef Hagenaars JA, McCutcheon AL. Applied latent class analysis. Cambridge: Cambridge University Press; 2002.CrossRef
34.
go back to reference Muthen LK, Muthen BO. Mplus [computer software]. Los Angeles, CA: Muthén & Muthén; 1998. Muthen LK, Muthen BO. Mplus [computer software]. Los Angeles, CA: Muthén & Muthén; 1998.
35.
go back to reference Ng CW, Luo N, Heng BH. Health status profiles in community-dwelling elderly using self-reported health indicators: a latent class analysis. Qual Life Res. 2014;23(10):2889–98.CrossRefPubMed Ng CW, Luo N, Heng BH. Health status profiles in community-dwelling elderly using self-reported health indicators: a latent class analysis. Qual Life Res. 2014;23(10):2889–98.CrossRefPubMed
36.
go back to reference George LK. Social factors and illness. In: Binstock RH, George LK, Marshall VW, Myers GC, Schulz JH, editors. Handbook of aging and the social sciences. 4th ed. San Diego: Academic Press; 1996. p. 229–52. George LK. Social factors and illness. In: Binstock RH, George LK, Marshall VW, Myers GC, Schulz JH, editors. Handbook of aging and the social sciences. 4th ed. San Diego: Academic Press; 1996. p. 229–52.
37.
go back to reference Van Campen C: Frail older persons in the Netherlands, Den Haag: SCP 2011,32. Van Campen C: Frail older persons in the Netherlands, Den Haag: SCP 2011,32.
38.
go back to reference Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB, Walston JD. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004;52(4):625–34.CrossRefPubMed Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB, Walston JD. Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004;52(4):625–34.CrossRefPubMed
39.
go back to reference Den Draak M, De Klerk M: Elderly migrants. Den Haag, SCP, 2011, 35. Den Draak M, De Klerk M: Elderly migrants. Den Haag, SCP, 2011, 35.
40.
go back to reference Peters LL, Boter H, Slaets JPJ, Buskens E. Development and measurement properties of the self assessment version of the INTERMED for the elderly to assess case complexity. JPsychosomatRes. 2013;74:518–22. Peters LL, Boter H, Slaets JPJ, Buskens E. Development and measurement properties of the self assessment version of the INTERMED for the elderly to assess case complexity. JPsychosomatRes. 2013;74:518–22.
41.
go back to reference Wiles JL, Wild K, Kerse N, Allen RE. Resilience from the point of view of older people:‘There's still life beyond a funny knee. Soc Sci Med. 2012;74(3):416–24.CrossRefPubMed Wiles JL, Wild K, Kerse N, Allen RE. Resilience from the point of view of older people:‘There's still life beyond a funny knee. Soc Sci Med. 2012;74(3):416–24.CrossRefPubMed
42.
go back to reference Mur-Veeman I, Hardy B, Steenbergen M, Wistow G. Development of integrated care in England and the Netherlands: managing across public–private boundaries. Health Policy. 2003;65(3):227–41.CrossRefPubMed Mur-Veeman I, Hardy B, Steenbergen M, Wistow G. Development of integrated care in England and the Netherlands: managing across public–private boundaries. Health Policy. 2003;65(3):227–41.CrossRefPubMed
43.
Metadata
Title
The frail older person does not exist: development of frailty profiles with latent class analysis
Authors
W. M. Looman
I. N. Fabbricotti
J. W. Blom
A. P. D. Jansen
J. E. Lutomski
S. F. Metzelthin
R. Huijsman
on behalf of the TOPICS-MDS Research Consortium
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2018
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-018-0776-5

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