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Published in: BMC Geriatrics 1/2017

Open Access 01-12-2017 | Research Article

Prevalence of frailty and its associated factors in older hospitalised patients in Vietnam

Authors: Huyen Thi Thanh Vu, Thanh Xuan Nguyen, Tu N. Nguyen, Anh Trung Nguyen, Robert Cumming, Sarah Hilmer, Thang Pham

Published in: BMC Geriatrics | Issue 1/2017

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Abstract

Background

Frailty is an emerging issue in geriatrics and gerontology. The prevalence of frailty is increasing as the population ages. Like many developing countries, Vietnam has a rapidly ageing population. However, there have been no studies about frailty in older people in Vietnam. This study aims to investigate the prevalence of frailty and its associated factors in older hospitalised patients at the National Geriatric Hospital in Hanoi, Vietnam.

Methods

Prospective observational study in inpatients aged ≥60 years at the National Geriatric Hospital in Hanoi, Vietnam from 4/2015 to 10/2015. Frailty was assessed using the Reported Edmonton Frail Scale (REFS) and Fried frailty phenotype.

Results

A total of 461 patients were recruited (56.8% female, mean age 76.2 ± 8.9 years). The prevalence of frailty was 31.9% according to the REFS. Using the Fried frailty criteria, the percentages of non-frail, pre-frail and frail participants were 24.5, 40.1 and 35.4%, respectively. Factors associated with frailty defined by REFS were age (OR 1.05 per year, 95% CI 1.03–1.08), poor reported nutritional status (OR 4.51, 95% CI 2.15–9.44), and not finishing high school (OR 2.18, 95% CI 1.37–3.46). Factors associated with frailty defined by the Fried frailty criteria included age (OR 1.07 per year, 95% CI 1.05–1.10), poor reported nutritional status (OR 2.96, 95%CI 1.43–6.11), not finishing high school (OR 1.58, 95% CI 1.01–2.46) and cardiovascular disease (OR 1.76, 95% CI 1.16–2.67).

Conclusions

While further studies are needed to examine the impact of frailty on outcomes in Vietnam, the observed high prevalence of frailty in older inpatients is likely to have implications for health policy and planning for the ageing population in Vietnam.
Literature
1.
go back to reference Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed
2.
go back to reference Raphael D, Cava M, Brown I, Renwick R, Heathcote K, Weir N, et al. Frailty: a public health perspective. Can J Public Health. 1995;86(4):224–7.PubMed Raphael D, Cava M, Brown I, Renwick R, Heathcote K, Weir N, et al. Frailty: a public health perspective. Can J Public Health. 1995;86(4):224–7.PubMed
3.
go back to reference de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JSM, Olde Rikkert MGM, Nijhuis-van der Sanden MWG. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev. 2011;10(1):104–14.CrossRefPubMed de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JSM, Olde Rikkert MGM, Nijhuis-van der Sanden MWG. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev. 2011;10(1):104–14.CrossRefPubMed
4.
go back to reference Martin FC, Brighton P. Frailty: Different tools for different purposes? Age Ageing. 2008;37(2):129–31.CrossRefPubMed Martin FC, Brighton P. Frailty: Different tools for different purposes? Age Ageing. 2008;37(2):129–31.CrossRefPubMed
5.
go back to reference Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP. Identifying frailty in hospitalized older adults with significant coronary artery disease. J Am Geriatr Soc. 2006;54(11):1674–81.CrossRefPubMed Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP. Identifying frailty in hospitalized older adults with significant coronary artery disease. J Am Geriatr Soc. 2006;54(11):1674–81.CrossRefPubMed
6.
go back to reference Ekerstad N, Swahn E, Janzon M, Alfredsson J, Lofmark R, Lindenberger M, et al. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation. 2011;124(22):2397–404.CrossRefPubMed Ekerstad N, Swahn E, Janzon M, Alfredsson J, Lofmark R, Lindenberger M, et al. Frailty is independently associated with short-term outcomes for elderly patients with non-ST-segment elevation myocardial infarction. Circulation. 2011;124(22):2397–404.CrossRefPubMed
7.
go back to reference Andela RM, Dijkstra A, Slaets JP, Sanderman R. Prevalence of frailty on clinical wards: description and implications. Int J Nurs Pract. 2010;16(1):14–9. Epub 2010/02/18CrossRefPubMed Andela RM, Dijkstra A, Slaets JP, Sanderman R. Prevalence of frailty on clinical wards: description and implications. Int J Nurs Pract. 2010;16(1):14–9. Epub 2010/02/18CrossRefPubMed
8.
go back to reference Hubbard RE, Peel NM, Samanta M, Gray LC, Mitnitski A, Rockwood K. Frailty status at admission to hospital predicts multiple adverse outcomes. Age Ageing. 2017:1–6. Epub 2017/05/23 Hubbard RE, Peel NM, Samanta M, Gray LC, Mitnitski A, Rockwood K. Frailty status at admission to hospital predicts multiple adverse outcomes. Age Ageing. 2017:1–6. Epub 2017/05/23
9.
go back to reference Kojima G. Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70(7):722–9. Epub 2016/03/05CrossRefPubMed Kojima G. Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70(7):722–9. Epub 2016/03/05CrossRefPubMed
10.
go back to reference Heuberger RA. The frailty syndrome: a comprehensive review. J Nutr Gerontol Geriatr. 2011;30(4):315–68.CrossRefPubMed Heuberger RA. The frailty syndrome: a comprehensive review. J Nutr Gerontol Geriatr. 2011;30(4):315–68.CrossRefPubMed
11.
go back to reference Hubbard RE, O'Mahony MS, Woodhouse KW. Medication prescribing in frail older people. Eur J Clin Pharmacol. 2013;69(3):319–26.CrossRefPubMed Hubbard RE, O'Mahony MS, Woodhouse KW. Medication prescribing in frail older people. Eur J Clin Pharmacol. 2013;69(3):319–26.CrossRefPubMed
12.
go back to reference He W, Muenchrath MN, Kowal P. U.S. Census Bureau, Shades of Gray: a cross-country study of health and well-being of the older populations in SAGE countries, 2007–2010. U.S. Washington, DC: Government Printing Office; 2012. He W, Muenchrath MN, Kowal P. U.S. Census Bureau, Shades of Gray: a cross-country study of health and well-being of the older populations in SAGE countries, 2007–2010. U.S. Washington, DC: Government Printing Office; 2012.
13.
go back to reference Nguyen TN, Cumming RG, Hilmer SN. A review of frailty in developing countries. J Nutr Health Aging. 2015;19(9):941–6. Epub 2015/10/21CrossRefPubMed Nguyen TN, Cumming RG, Hilmer SN. A review of frailty in developing countries. J Nutr Health Aging. 2015;19(9):941–6. Epub 2015/10/21CrossRefPubMed
14.
go back to reference Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8(4):355–69.CrossRefPubMed Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8(4):355–69.CrossRefPubMed
15.
go back to reference WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–63.
16.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56. Epub 2001/03/17CrossRefPubMed Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56. Epub 2001/03/17CrossRefPubMed
17.
go back to reference Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13(10):881–9. Epub 2009/11/20CrossRefPubMed Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13(10):881–9. Epub 2009/11/20CrossRefPubMed
18.
go back to reference Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A task force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12(1):29–37. Epub 2008/01/01CrossRefPubMed Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A task force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12(1):29–37. Epub 2008/01/01CrossRefPubMed
19.
go back to reference Hilmer SN, Perera V, Mitchell S, Murnion BP, Dent J, Bajorek B, et al. The assessment of frailty in older people in acute care. Australas J Ageing. 2009;28(4):182–8.CrossRefPubMed Hilmer SN, Perera V, Mitchell S, Murnion BP, Dent J, Bajorek B, et al. The assessment of frailty in older people in acute care. Australas J Ageing. 2009;28(4):182–8.CrossRefPubMed
20.
go back to reference Perera V, Bajorek BV, Matthews S, Hilmer SN. The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age Ageing. 2009;38(2):156–62.CrossRefPubMed Perera V, Bajorek BV, Matthews S, Hilmer SN. The impact of frailty on the utilisation of antithrombotic therapy in older patients with atrial fibrillation. Age Ageing. 2009;38(2):156–62.CrossRefPubMed
21.
go back to reference Rose M, Pan H, Levinson MR, Staples M. Can frailty predict complicated care needs and length of stay? Intern Med J. 2014;44(8):800–5.CrossRefPubMed Rose M, Pan H, Levinson MR, Staples M. Can frailty predict complicated care needs and length of stay? Intern Med J. 2014;44(8):800–5.CrossRefPubMed
22.
go back to reference Osborne C, Charles A, Hare A, Shipway D. Frailty predicts length of hospital stay in urology patients. Eur Urol Suppl. 2015;14(2):e658.CrossRef Osborne C, Charles A, Hare A, Shipway D. Frailty predicts length of hospital stay in urology patients. Eur Urol Suppl. 2015;14(2):e658.CrossRef
23.
go back to reference Mitchell SJ, Hilmer SN, Murnion BP, Matthews S. Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: Impact of ageing and frailty. J Clin Pharm Ther. 2011;36(3):327–35.CrossRefPubMed Mitchell SJ, Hilmer SN, Murnion BP, Matthews S. Hepatotoxicity of therapeutic short-course paracetamol in hospital inpatients: Impact of ageing and frailty. J Clin Pharm Ther. 2011;36(3):327–35.CrossRefPubMed
24.
go back to reference Bennett A, Gnjidic D, Gillett M, Carroll P, Matthews S, Johnell K, et al. Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: A prospective cohort study. Drugs Aging. 2014;31(3):225–32.CrossRefPubMed Bennett A, Gnjidic D, Gillett M, Carroll P, Matthews S, Johnell K, et al. Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: A prospective cohort study. Drugs Aging. 2014;31(3):225–32.CrossRefPubMed
25.
go back to reference Capistrant BD, Glymour MM, Berkman LF. Assessing mobility difficulties for cross-national comparisons: results from the World Health Organization Study on Global AGEing and Adult Health. J Am Geriatr Soc. 2014;62(2):329–35. Epub 2014/01/21CrossRefPubMedPubMedCentral Capistrant BD, Glymour MM, Berkman LF. Assessing mobility difficulties for cross-national comparisons: results from the World Health Organization Study on Global AGEing and Adult Health. J Am Geriatr Soc. 2014;62(2):329–35. Epub 2014/01/21CrossRefPubMedPubMedCentral
26.
go back to reference Arokiasamy P, Uttamacharya U, Jain K, Biritwum RB, Yawson AE, Wu F, et al. The impact of multimorbidity on adult physical and mental health in low- and middle-income countries: what does the study on global ageing and adult health (SAGE) reveal? BMC Med. 2015;13:178. Epub 2015/08/05CrossRefPubMedPubMedCentral Arokiasamy P, Uttamacharya U, Jain K, Biritwum RB, Yawson AE, Wu F, et al. The impact of multimorbidity on adult physical and mental health in low- and middle-income countries: what does the study on global ageing and adult health (SAGE) reveal? BMC Med. 2015;13:178. Epub 2015/08/05CrossRefPubMedPubMedCentral
27.
go back to reference Boutayeb A. The double burden of communicable and non-communicable diseases in developing countries. Trans R Soc Trop Med Hyg. 2006;100(3):191–9. Epub 2005/11/09CrossRefPubMed Boutayeb A. The double burden of communicable and non-communicable diseases in developing countries. Trans R Soc Trop Med Hyg. 2006;100(3):191–9. Epub 2005/11/09CrossRefPubMed
28.
go back to reference Bonnefoy M, Berrut G, Lesourd B, Ferry M, Gilbert T, Guerin O, et al. Frailty and nutrition: searching for evidence. J Nutr Health Aging. 2015;19(3):250–7. Epub 2015/03/04CrossRefPubMed Bonnefoy M, Berrut G, Lesourd B, Ferry M, Gilbert T, Guerin O, et al. Frailty and nutrition: searching for evidence. J Nutr Health Aging. 2015;19(3):250–7. Epub 2015/03/04CrossRefPubMed
29.
go back to reference Vellas BJ, Hunt WC, Romero LJ, Koehler KM, Baumgartner RN, Garry PJ. Changes in nutritional status and patterns of morbidity among free-living elderly persons: a 10-year longitudinal study. Nutrition. 1997;13(6):515–9. Epub 1997/06/01CrossRefPubMed Vellas BJ, Hunt WC, Romero LJ, Koehler KM, Baumgartner RN, Garry PJ. Changes in nutritional status and patterns of morbidity among free-living elderly persons: a 10-year longitudinal study. Nutrition. 1997;13(6):515–9. Epub 1997/06/01CrossRefPubMed
30.
go back to reference Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G, et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging. 2008;12(7):433–50. Epub 2008/07/11CrossRefPubMedPubMedCentral Rolland Y, Czerwinski S, Abellan Van Kan G, Morley JE, Cesari M, Onder G, et al. Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives. J Nutr Health Aging. 2008;12(7):433–50. Epub 2008/07/11CrossRefPubMedPubMedCentral
31.
go back to reference Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, et al. The asia-pacific clinical practice guidelines for the management of frailty. J Am Med Dir Assoc. 2017;18(7):564–75. Epub 2017/06/27CrossRefPubMed Dent E, Lien C, Lim WS, Wong WC, Wong CH, Ng TP, et al. The asia-pacific clinical practice guidelines for the management of frailty. J Am Med Dir Assoc. 2017;18(7):564–75. Epub 2017/06/27CrossRefPubMed
32.
go back to reference Theou O, Brothers TD, Rockwood MR, Haardt D, Mitnitski A, Rockwood K. Exploring the relationship between national economic indicators and relative fitness and frailty in middle-aged and older europeans. Age Ageing. 2013;42(5):614–9.CrossRefPubMedPubMedCentral Theou O, Brothers TD, Rockwood MR, Haardt D, Mitnitski A, Rockwood K. Exploring the relationship between national economic indicators and relative fitness and frailty in middle-aged and older europeans. Age Ageing. 2013;42(5):614–9.CrossRefPubMedPubMedCentral
33.
go back to reference Hoi le V, Phuc HD, Dung TV, Chuc NT, Lindholm L. Remaining life expectancy among older people in a rural area of Vietnam: trends and socioeconomic inequalities during a period of multiple transitions. BMC Public Health. 2009;9:471. Epub 2009/12/19CrossRefPubMedPubMedCentral Hoi le V, Phuc HD, Dung TV, Chuc NT, Lindholm L. Remaining life expectancy among older people in a rural area of Vietnam: trends and socioeconomic inequalities during a period of multiple transitions. BMC Public Health. 2009;9:471. Epub 2009/12/19CrossRefPubMedPubMedCentral
34.
go back to reference Afilalo J, Alexander KP, Mack MJ, Maurer MS, Green P, Allen LA, et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2014;63(8):747–62.CrossRefPubMed Afilalo J, Alexander KP, Mack MJ, Maurer MS, Green P, Allen LA, et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2014;63(8):747–62.CrossRefPubMed
35.
go back to reference Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103(11):1616–21.CrossRefPubMed Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103(11):1616–21.CrossRefPubMed
36.
go back to reference Hoang VM, Dao LH, Wall S, Nguyen TK, Byass P. Cardiovascular disease mortality and its association with socioeconomic status: findings from a population-based cohort study in rural Vietnam, 1999-2003. Prev Chronic Dis. 2006;3(3):A89. Epub 2006/06/17PubMed Hoang VM, Dao LH, Wall S, Nguyen TK, Byass P. Cardiovascular disease mortality and its association with socioeconomic status: findings from a population-based cohort study in rural Vietnam, 1999-2003. Prev Chronic Dis. 2006;3(3):A89. Epub 2006/06/17PubMed
37.
go back to reference Islam SM, Purnat TD, Phuong NT, Mwingira U, Schacht K, Froschl G. Non-communicable diseases (NCDs) in developing countries: a symposium report. Glob Health. 2014;10:81. Epub 2014/12/17CrossRef Islam SM, Purnat TD, Phuong NT, Mwingira U, Schacht K, Froschl G. Non-communicable diseases (NCDs) in developing countries: a symposium report. Glob Health. 2014;10:81. Epub 2014/12/17CrossRef
38.
go back to reference Green AR, Carrillo JE, Betancourt JR. Why the disease-based model of medicine fails our patients. West J Med. 2002;176(2):141–3. Epub 2002/03/19PubMedPubMedCentral Green AR, Carrillo JE, Betancourt JR. Why the disease-based model of medicine fails our patients. West J Med. 2002;176(2):141–3. Epub 2002/03/19PubMedPubMedCentral
Metadata
Title
Prevalence of frailty and its associated factors in older hospitalised patients in Vietnam
Authors
Huyen Thi Thanh Vu
Thanh Xuan Nguyen
Tu N. Nguyen
Anh Trung Nguyen
Robert Cumming
Sarah Hilmer
Thang Pham
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2017
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-017-0609-y

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