Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Geriatrics
Published in: BMC Geriatrics 1/2016

Open Access 01-12-2016 | Research Article

Health-related quality of life in older depressed psychogeriatric patients: one year follow-up

Authors: Anne-Sofie Helvik, Kirsten Corazzini, Geir Selbæk, Guro Hanevold Bjørkløf, Jerson Laks, Jūratė Šaltytė Benth, Truls Østbye, Knut Engedal

Published in: BMC Geriatrics | Issue 1/2016

Login to get access

Abstract

Background

Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change of HQoL one year after admission for treatment of depression, secondly to explore if improved HQoL was associated with remission of depression at follow-up and lastly to study how HQoL in patients with remission from depression were compared to a reference group of older persons without depression.

Method

This study had the one year follow-up information of 108 older patients (≥60 years), all hospitalized for depression at baseline, and a reference sample of 106 community-living older adults (≥60 years) without depression. HQoL was measured using the EuroQol Group’s EQ-5D Index and a visual analog scale (EQ-VAS). Depression and remission were diagnosed according to ICD-10. Socio-demographic variables (age, gender, and education), depressive symptom score (Montgomery-Aasberg Depression Rating Scale), cognitive functioning (Mini Mental State Examination scale), instrumental activities of daily living (the Lawton and Brody’s Instrumental Activities of Daily Living Scale), and poor general physical health (General Medical Health Rating) were included as covariates.

Results

HQoL had improved at follow-up for the total group of depressed patients, as indicated by better scores on the EQ-5D Index and EQ-VAS. In the multivariate linear regression model, improved EQ-5D Index and EQ-VAS was significantly better in those with remission of depression and those with better baseline physical health. In adjusted analyses, the HQoL in patients with remission from depression at follow-up did not differ from the HQoL in a reference group without depression.

Conclusion

Older hospital patients with depression who experienced remission one year after admission gained HQoL and their HQoL was comparable with the HQoL in a reference group of older adults without depression when adjusting for differences in socio-demographics and health conditions.
Literature
1.
World Health Organization. The global burden of disease: 2004 update. In: Book World Health Organization: The global burden of disease. Geneva: World Health Organization; 2008.
2.
Hasche L, Morrow-Howell N, editors. Depression. New York: Wiley; 2007.
3.
Luppa M, Sikorski C, Luck T, Ehreke L, Konnopka A, Wiese B, Weyerer, S, König, H-H, Riedel-Heller, SG. Age- and gender-specific prevalence of depression in latest-life – Systematic review and meta-analysis. J Affect Disord. 2012;136:212–21.
4.
Kessler RC, Birnbaum HG, Shahly V, Bromet E, Hwang I, McLaughlin KA, Sampson N, Andrade LH, de Girolamo G, Demyttenaere K, Haro JM, Karam AN, Kostyuchenko S, Kovess V, Lara C, Levinson D, Matschinger H, Nakane Y, Browne MO, Ormel J, Posada-Villa J, Sagar R, Stein DJ. Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the WHO World Mental Health Survey Initiative. Depress Anxiety. 2010;27:351–64.CrossRefPubMedPubMedCentral
5.
6.
Hermann-Lingen C, Klemme H, Meyer T. Depressed mood, physician-rated prognoses and comorbidity as in dependent predictors of 1- year mortality in consecutive medical inpatients. J Psychosom Res. 2001;2001:292–301.
7.
Ladwig KH, Kieser M, Konig J, Breithardt G, Borggrefe M. Affective disorders and survival after acute myocardial infarction. Results from the post-infarction late potential study. Eur Heart J. 1991;12:959–64.PubMed
8.
Frasure-Smith N, Lesperance F, Gravel G, Masson A, Juneau M, Talajic M, Bourassa MG. Social support, depression, and mortality during the first year after myocardial infarction. Circulation. 2000;101:1919–24.CrossRefPubMed
9.
10.
Bowling A. The concept of quality of life in relation to health. Medicina Nei Secoli Arte E Scienza. 1995;7:633–45.
11.
The_WHOgroup. The World Health Organization quality of life assessment (WHOQOL): Position paper from the World Health Organization. Soc Sci Med. 1995;41:1403–9.CrossRef
12.
13.
Power M, Quinn K, Schmidt S. Development of the WHOQOL-old module. Qual Life Res. 2005;14:2197–214.CrossRefPubMed
14.
Winkler I, Matschinger H, Angermeyer MC. [The WHOQOL-OLD]. Psychother Psychosom Med Psychol. 2006;56:63–9.CrossRefPubMed
15.
Rapley M. Quality of Life Research: A Critical Introduction. Great Britain: SAGE Publications Ltd; 2003. p. 43–56.CrossRef
16.
Bowling A, Ebrahim S. Handbook of Health Research Methods: Investigation, Measurement and Analysis. England: Open University Press; 2005. p. 428–44.
17.
Dolan P, Gudex C, Kind P, Williams A. The time trade-off method: results from a general population study. Health Econ. 1996;5:141–54.CrossRefPubMed
18.
Lapid MI, Piderman KM, Ryan SM, Somers KJ, Clark MM, Rummans TA. Improvement of quality of life in hospitalized depressed elderly. Int Psychogeriatr. 2011;23:485–95.CrossRefPubMed
19.
Mazumdar S, Reynolds 3rd CF, Houck PR, Frank E, Dew MA, Kupfer DJ. Quality of life in elderly patients with recurrent major depression: a factor analysis of the General Life Functioning Scale. Psychiatry Res. 1996;63:183–90.CrossRefPubMed
20.
Tatulian S, Yavorskaya V, Vasiliev S, Shustrova G. The Question of Research into the Quality of Life of Patients with Recurrent Depressive Disorders in Advanced Age. Int J Ment Health. 2004;33:39–46.
21.
Lavretsky H, Kurbanyan K, Ballmaier M, Mintz J, Toga A, Kumar A. Sex differences in brain structure in geriatric depression. Am J Geriatr Psychiatry. 2004;12:653–7.CrossRefPubMed
22.
Shmuely Y, Baumgarten M, Rovner B, Berlin J. Predictors of improvement in health-related quality of life among elderly patients with depression. Int Psychogeriatr. 2001;13:63–73.CrossRefPubMed
23.
Ho C, Feng L, Fam J, Mahendran R, Kua EH, Ng TP. Coexisting medical comorbidity and depression: multiplicative effects on health outcomes in older adults. Int Psychogeriatr. 2014;26:1221–9.CrossRefPubMed
24.
WHO. The ICD-10 classification of mental and behavioural disorders : clinical descriptions and diagnostic guidelines. Geneva: World Health Organization; 1992.
25.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.CrossRefPubMed
26.
Engedal K, Haugen P, Gilje K, Laake P. Efficacy of short mental tests in the detection of mental impairment in old age. Compr Gerontol A. 1988;2:87–93.PubMed
27.
Strobel K, Engedal K. MMSE-NR, Norsk revidert Mini Mental Status Evaluering. In: Book MMSE-NR, Norsk revidert Mini Mental Status Evaluering. Oslo: Nasjonal kompetansetjeneste i aldring og helse; 2008.
28.
29.
McDowell I. General Health Status and Quality of Life. In: AnonymousMeasuring Health A Guide to Rating Scales and Questionnaires. Oxford: Oxford University Press; 2006. p. 520.CrossRef
30.
Solberg T, Olsen J, Ingebrigtsen T, Hofoss D, Nygaard O. Health-related quality of life assessment by the EuroQol-5D can provide cost-utility data in the field of low-back surgery. EurSpine J. 2005;14:1000–7.
31.
Revicki DA, Simon GE, Chan K, Katon W, Heiligenstein J. Depression, health-related quality of life, and medical cost outcomes of receiving recommended levels of antidepressant treatment. J Fam Pract. 1998;47:446–52.PubMed
32.
Revicki DA, Wood M. Patient-assigned health state utilities for depression-related outcomes: differences by depression severity and antidepressant medications. J Affect Disord. 1998;48:25–36.CrossRefPubMed
33.
Peveler R, Kendrick T, Buxton M, Longworth L, Baldwin D, Moore M, Chatwin J, Goddard J, Thornett A, Smith H. A randomised controlled trial to compare the cost-effectiveness of tricyclic antidepressants, selective serotonin reuptake inhibitors and lofepramine. Health Technol Assess. 2005;9:1–134. iii.CrossRefPubMed
34.
Sapin C, Fantino B, Nowicki ML, Kind P. Usefulness of EQ-5D in assessing health status in primary care patients with major depressive disorder. Health Qual Life Outcomes. 2004;2:20.CrossRefPubMedPubMedCentral
35.
Sobocki P, Ekman M, Agren H, Krakau I, Runeson B, Martensson B, Jonsson B. Health-related quality of life measured with EQ-5D in patients treated for depression in primary care. Value Health. 2007;10:153–60.CrossRefPubMed
36.
Figved W, Opland V, Frihagen F, Jervidalo T, Madsen JE, Nordsletten L. Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures. Clin Orthop Relat Res. 2009;467:2426–35.CrossRefPubMedPubMedCentral
37.
Gjertsen JE, Engesaeter LB, Furnes O, Havelin LI, Steindal K, Vinje T, Fevang JM. The Norwegian Hip Fracture Register: experiences after the first 2 years and 15,576 reported operations. Acta Orthop. 2008;79:583–93.CrossRefPubMed
38.
Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–9.CrossRefPubMed
39.
Engedal K, Kvaal K, Korsnes M, Barca ML, Borza T, Selbaek G, Aakhus, E. The validity of the Montgomery-Aasberg depression rating scale as a screening tool for depression in later life. J Affect Disord. 2012;141:227–32.CrossRefPubMed
40.
41.
Naess H, Nyland HI, Thomassen L, Aarseth J, Myhr KM. Mild depression in young adults with cerebral infarction at long-term follow-up: a population-based study. Eur J Neurol. 2005;12:194–8.CrossRefPubMed
42.
Thommessen B, Aarsland D, Braekhus A, Oksengaard AR, Engedal K, Laake K. The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease. Int J Geriatr Psychiatry. 2002;17:78–84.CrossRefPubMed
43.
Bystad M, Skjerve A, Strobel C. Assessing dementia: A presentation of MMSE-NR, clock-drawing test and informant scales. Tidsskrift for Norsk Psykologforening. 2013;50:7–11.
44.
Lyketsos CG, Galik E, Steele C, Steinberg M, Rosenblatt A, Warren A, Sheppard JM, Baker A, Brandt J. The General Medical Health Rating: a bedside global rating of medical comorbidity in patients with dementia. J Am Geriatr Soc. 1999;47:487–91.CrossRefPubMed
45.
Sylliaas H, Selbaek G, Bergland A. Do behavioral disturbances predict falls among nursing home residents? Aging Clin Exp Res. 2012;24:251–6.CrossRefPubMed
46.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.CrossRefPubMed
47.
Grov EK, Fossa SD, Dahl AA. Activity of daily living problems in older cancer survivors: a population-based controlled study. Health Soc Care Community. 2010;18:396–406.PubMed
48.
Omli R, Hunskaar S, Mykletun A, Romild U, Kuhry E. Urinary incontinence and risk of functional decline in older women: data from the Norwegian HUNT-study. BMC Geriatr. 2013;13:47.CrossRefPubMedPubMedCentral
49.
Valen-Sendstad A, Engedal K, Stray-Pedersen B, ADACT study Group, Strobel C, Barnett L, Nurminemi, M, Meyer, N. Effects of Hormone Therapy on Depressive Symptoms and Cognitive Functions in Women With Alzheimer Disease: A 12 Month Randomized, Double-Blind, Placebo-Controlled Study of Low-Dose Estradiol and Norethisterone. Am J Geriatr Psychiatry. 2010;18:11–20.
50.
HUNT. The Health Study in Nord-Trøndelag (HUNT). In: Book The Health Study in Nord-Trøndelag (HUNT. Verdal: HUNT; 2011.
51.
Hasche LK, Morrow-Howell N, Proctor EK. Quality of life outcomes for depressed and nondepressed older adults in community long-term care. Am J Geriatr Psychiatr. 2010;18:544–53.CrossRef
52.
Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. Jama. 1995;273:59–65.CrossRefPubMed
53.
Bjorklof GH, Engedal K, Selbaek G, Kouwenhoven SE, Helvik AS. Coping and depression in old age: a literature review. Dement Geriatr Cogn Disord. 2013;35:121–54.CrossRefPubMed
54.
Kopec JA, Willison KD. A comparative review of four preference-weighted measures of health-related quality of life. J Clin Epidemiol. 2003;56:317–25.CrossRefPubMed
55.
Gottlieb A, Golander H, Bar-Tal Y, Gottlieb D. The influence of social support and perceived control on handicap and quality of life after stroke. Aging (Milano). 2001;13:11–5.
56.
Perkins EA, Small BJ, Balducci L, Extermann M, Robb C, Haley WE. Individual differences in well-being in older breast cancer survivors. Crit Rev Oncol Hematol. 2007;62:74–83.CrossRefPubMedPubMedCentral
57.
Chen W, Okumiya K, Wada T, Sakamoto R, Imai H, Ishimoto Y, Kimura Y, Fukutomi E, Fujisawa M, Shih HI. Social cohesion and health in old age: a study in southern Taiwan. Int Psychogeriatr. 2015;1–9.
58.
Pettersen KI, Kvan E, Rollag A, Stavem K, Reikvam A. Health-related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction. BMC Cardiovasc Disord. 2008;8:28.CrossRefPubMedPubMedCentral
Metadata
Title
Health-related quality of life in older depressed psychogeriatric patients: one year follow-up
Authors
Anne-Sofie Helvik
Kirsten Corazzini
Geir Selbæk
Guro Hanevold Bjørkløf
Jerson Laks
Jūratė Šaltytė Benth
Truls Østbye
Knut Engedal
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2016
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-016-0310-6

Other articles of this Issue 1/2016

BMC Geriatrics 1/2016 Go to the issue

Research article

Exploring psychosocial interventions for people with dementia that enhance personhood and relate to legacy- an integrative review

Study protocol

Impact of a transition nurse program on the prevention of thirty-day hospital readmissions of elderly patients discharged from short-stay units: study protocol of the PROUST stepped-wedge cluster randomised trial

Research Article

Effect of anaemia on hand grip strength, walking speed, functionality and 1 year mortality in older hospitalized patients

Research article

A cross-sectional study of the association between mobility test performance and personality among older adults

Research article

Correlates of self-report chronic insomnia disorders with 1–6 month and 6-month durations in home-dwelling urban older adults - the Shih-Pai Sleep Study in Taiwan: a cross-sectional community study

Study protocol

Exercise and fall prevention self-management to reduce mobility-related disability and falls after fall-related lower limb fracture in older people: protocol for the RESTORE (Recovery Exercises and STepping On afteR fracturE) randomised controlled trial

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits