Skip to main content
Top
Published in: BMC Geriatrics 1/2015

Open Access 01-12-2015 | Research article

Derivation of a frailty index from the interRAI acute care instrument

Authors: Ruth E Hubbard, Nancye M Peel, Mayukh Samanta, Leonard C Gray, Brant E Fries, Arnold Mitnitski, Kenneth Rockwood

Published in: BMC Geriatrics | Issue 1/2015

Login to get access

Abstract

Background

A better understanding of the health status of older inpatients could underpin the delivery of more individualised, appropriate health care.

Methods

1418 patients aged ≥ 70 years admitted to 11 hospitals in Australia were evaluated at admission using the interRAI assessment system for Acute Care. This instrument surveys a large number of domains, including cognition, communication, mood and behaviour, activities of daily living, continence, nutrition, skin condition, falls, and medical diagnosis.

Results

Variables across multiple domains were selected as health deficits. Dichotomous data were coded as symptom absent (0 deficit) or present (1 deficit). Ordinal scales were recoded as 0, 0.5 or 1 deficit based on face validity and the distribution of data.
Individual deficit scores were summed and divided by the total number considered (56) to yield a Frailty index (FI-AC) with theoretical range 0–1. The index was normally distributed, with a mean score of 0.32 (±0.14), interquartile range 0.22 to 0.41. The 99% limit to deficit accumulation was 0.69, below the theoretical maximum of 1.0.
In logistic regression analysis including age, gender and FI-AC as covariates, each 0.1 increase in the FI-AC increased the likelihood of inpatient mortality twofold (OR: 2.05 [95% CI 1.70 – 2.48]).

Conclusions

Quantification of frailty status at hospital admission can be incorporated into an existing assessment system, which serves other clinical and administrative purposes. This could optimise clinical utility and minimise costs.
The variables used to derive the FI-AC are common to all interRAI instruments, and could be used to precisely measure frailty across the spectrum of health care.
Literature
1.
go back to reference Ellis G, Whitehead MA, Robinson D, O’Neill D, Langhorne P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ. 2011;343:d6553.CrossRefPubMedPubMedCentral Ellis G, Whitehead MA, Robinson D, O’Neill D, Langhorne P. Comprehensive geriatric assessment for older adults admitted to hospital: meta-analysis of randomised controlled trials. BMJ. 2011;343:d6553.CrossRefPubMedPubMedCentral
2.
go back to reference Ekdahl AW, Hellstrom I, Andersson L, Friedrichsen M. Too complex and time-consuming to fit in! Physicians’ experiences of elderly patients and their participation in medical decision making: a grounded theory study. BMJ Open. 2012;2:3. Ekdahl AW, Hellstrom I, Andersson L, Friedrichsen M. Too complex and time-consuming to fit in! Physicians’ experiences of elderly patients and their participation in medical decision making: a grounded theory study. BMJ Open. 2012;2:3.
3.
go back to reference Ong AC, Sabanathan K, Potter JF, Myint PK. High mortality of older patients admitted to hospital from care homes and insight into potential interventions to reduce hospital admissions from care homes: the Norfolk experience. Arch Gerontol Geriatr. 2011;53(3):316–9.CrossRefPubMed Ong AC, Sabanathan K, Potter JF, Myint PK. High mortality of older patients admitted to hospital from care homes and insight into potential interventions to reduce hospital admissions from care homes: the Norfolk experience. Arch Gerontol Geriatr. 2011;53(3):316–9.CrossRefPubMed
4.
go back to reference Gaynor EJ, Geoghegan SE, O’Neill D. Ageism in stroke rehabilitation studies. Age Ageing. 2014;43(3):429–31.CrossRefPubMed Gaynor EJ, Geoghegan SE, O’Neill D. Ageism in stroke rehabilitation studies. Age Ageing. 2014;43(3):429–31.CrossRefPubMed
5.
go back to reference Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed
6.
go back to reference Morley JE, Vellas B, Abellan van Kan G, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7.CrossRefPubMedPubMedCentral Morley JE, Vellas B, Abellan van Kan G, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7.CrossRefPubMedPubMedCentral
7.
go back to reference Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27(1):17–26.CrossRefPubMed Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27(1):17–26.CrossRefPubMed
8.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRefPubMed Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRefPubMed
9.
go back to reference Dent E, Chapman I, Howell S, Piantadosi C, Visvanathan R. Frailty and functional decline indices predict poor outcomes in hospitalised older people. Age Ageing. 2014;43(4):477–84.CrossRefPubMed Dent E, Chapman I, Howell S, Piantadosi C, Visvanathan R. Frailty and functional decline indices predict poor outcomes in hospitalised older people. Age Ageing. 2014;43(4):477–84.CrossRefPubMed
10.
go back to reference Hubbard RE, O’Mahony MS, Woodhouse KW. Characterising frailty in the clinical setting–a comparison of different approaches. Age Ageing. 2009;38(1):115–9.CrossRefPubMed Hubbard RE, O’Mahony MS, Woodhouse KW. Characterising frailty in the clinical setting–a comparison of different approaches. Age Ageing. 2009;38(1):115–9.CrossRefPubMed
11.
go back to reference Cesari M, Gambassi G, Abellan van Kan G, Vellas B. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing. 2014;43(1):10–2.CrossRefPubMed Cesari M, Gambassi G, Abellan van Kan G, Vellas B. The frailty phenotype and the frailty index: different instruments for different purposes. Age Ageing. 2014;43(1):10–2.CrossRefPubMed
12.
go back to reference Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing. 2014;43(1):127–32.CrossRefPubMed Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing. 2014;43(1):127–32.CrossRefPubMed
13.
go back to reference Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122–6.CrossRefPubMed Krishnan M, Beck S, Havelock W, Eeles E, Hubbard RE, Johansen A. Predicting outcome after hip fracture: using a frailty index to integrate comprehensive geriatric assessment results. Age Ageing. 2014;43(1):122–6.CrossRefPubMed
14.
go back to reference Brand CA, Martin-Khan M, Wright O, Jones RN, Morris JN, Travers CM, et al. Development of quality indicators for monitoring outcomes of frail elderly hospitalised in acute care health settings: study protocol. BMC Health Serv Res. 2011;11:281.CrossRefPubMedPubMedCentral Brand CA, Martin-Khan M, Wright O, Jones RN, Morris JN, Travers CM, et al. Development of quality indicators for monitoring outcomes of frail elderly hospitalised in acute care health settings: study protocol. BMC Health Serv Res. 2011;11:281.CrossRefPubMedPubMedCentral
15.
go back to reference Travers C, Byrne G, Pachana N, Klein K, Gray L. Prospective observational study of dementia and delirium in the acute hospital setting. Intern Med J. 2013;43(3):262–9.CrossRefPubMed Travers C, Byrne G, Pachana N, Klein K, Gray L. Prospective observational study of dementia and delirium in the acute hospital setting. Intern Med J. 2013;43(3):262–9.CrossRefPubMed
16.
go back to reference Lakhan P, Jones M, Wilson A, Courtney M, Hirdes J, Gray LC. A prospective cohort study of geriatric syndromes among older medical patients admitted to acute care hospitals. J Am Geriatr Soc. 2011;59(11):2001–8.CrossRefPubMed Lakhan P, Jones M, Wilson A, Courtney M, Hirdes J, Gray LC. A prospective cohort study of geriatric syndromes among older medical patients admitted to acute care hospitals. J Am Geriatr Soc. 2011;59(11):2001–8.CrossRefPubMed
17.
go back to reference Gray LC, Bernabei R, Berg K, Finne-Soveri H, Fries BE, Hirdes JP, et al. Standardizing assessment of elderly people in acute care: the interRAI Acute Care instrument. J Am Geriatr Soc. 2008;56(3):536–41.CrossRefPubMed Gray LC, Bernabei R, Berg K, Finne-Soveri H, Fries BE, Hirdes JP, et al. Standardizing assessment of elderly people in acute care: the interRAI Acute Care instrument. J Am Geriatr Soc. 2008;56(3):536–41.CrossRefPubMed
18.
go back to reference Gray LC, Berg K, Fries BE, Henrard JC, Hirdes JP, Steel K, et al. Sharing clinical information across care settings: the birth of an integrated assessment system. BMC Health Serv Res. 2009;9:71.CrossRefPubMedPubMedCentral Gray LC, Berg K, Fries BE, Henrard JC, Hirdes JP, Steel K, et al. Sharing clinical information across care settings: the birth of an integrated assessment system. BMC Health Serv Res. 2009;9:71.CrossRefPubMedPubMedCentral
19.
go back to reference Devriendt E, Wellens NI, Flamaing J, Declercq A, Moons P, Boonen S, et al. The interRAI Acute Care instrument incorporated in an eHealth system for standardized and web-based geriatric assessment: strengths, weaknesses, opportunities and threats in the acute hospital setting. BMC Geriatr. 2013;13:90.CrossRefPubMedPubMedCentral Devriendt E, Wellens NI, Flamaing J, Declercq A, Moons P, Boonen S, et al. The interRAI Acute Care instrument incorporated in an eHealth system for standardized and web-based geriatric assessment: strengths, weaknesses, opportunities and threats in the acute hospital setting. BMC Geriatr. 2013;13:90.CrossRefPubMedPubMedCentral
20.
go back to reference Landi F, Tua E, Onder G, Carrara B, Sgadari A, Rinaldi C, et al. Minimum data set for home care: a valid instrument to assess frail older people living in the community. Med Care. 2000;38(12):1184–90.CrossRefPubMed Landi F, Tua E, Onder G, Carrara B, Sgadari A, Rinaldi C, et al. Minimum data set for home care: a valid instrument to assess frail older people living in the community. Med Care. 2000;38(12):1184–90.CrossRefPubMed
21.
go back to reference Wellens NI, Van Lancker A, Flamaing J, Gray L, Moons P, Verbeke G, et al. Interrater reliability of the interRAI Acute Care (interRAI AC). Arch Gerontol Geriatr. 2012;55(1):165–72.CrossRefPubMed Wellens NI, Van Lancker A, Flamaing J, Gray L, Moons P, Verbeke G, et al. Interrater reliability of the interRAI Acute Care (interRAI AC). Arch Gerontol Geriatr. 2012;55(1):165–72.CrossRefPubMed
23.
go back to reference Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003;58(3):232–7.CrossRefPubMed Evert J, Lawler E, Bogan H, Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J Gerontol A Biol Sci Med Sci. 2003;58(3):232–7.CrossRefPubMed
24.
go back to reference Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D. Income and the midlife peak in common mental disorder prevalence. Psychol Med. 2011;41(7):1365–72.CrossRefPubMed Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D. Income and the midlife peak in common mental disorder prevalence. Psychol Med. 2011;41(7):1365–72.CrossRefPubMed
25.
26.
go back to reference Rockwood K, Jones D, Wang Y, Carver D, Mitnitski A. Failure to complete performance-based measures is associated with poor health status and an increased risk of death. Age Ageing. 2007;36(2):225–8.CrossRefPubMed Rockwood K, Jones D, Wang Y, Carver D, Mitnitski A. Failure to complete performance-based measures is associated with poor health status and an increased risk of death. Age Ageing. 2007;36(2):225–8.CrossRefPubMed
27.
go back to reference Pena FG, Theou O, Wallace L, Brothers TD, Gill TM, Gahbauer EA, et al. Comparison of alternate scoring of variables on the performance of the frailty index. BMC Geriatr. 2014;14:25.CrossRefPubMedPubMedCentral Pena FG, Theou O, Wallace L, Brothers TD, Gill TM, Gahbauer EA, et al. Comparison of alternate scoring of variables on the performance of the frailty index. BMC Geriatr. 2014;14:25.CrossRefPubMedPubMedCentral
28.
go back to reference Eeles EM, White S, Bayer T. Inability to complete cognitive assessment is a marker of adverse risk. Age Ageing. 2009;38(5):633–4. author reply 634–635.CrossRefPubMed Eeles EM, White S, Bayer T. Inability to complete cognitive assessment is a marker of adverse risk. Age Ageing. 2009;38(5):633–4. author reply 634–635.CrossRefPubMed
29.
go back to reference Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010;65(4):377–81.CrossRefPubMed Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010;65(4):377–81.CrossRefPubMed
30.
go back to reference Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989–95.CrossRefPubMed Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, et al. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989–95.CrossRefPubMed
31.
go back to reference Rockwood K, Mogilner A, Mitnitski A. Changes with age in the distribution of a frailty index. Mech Ageing Dev. 2004;125(7):517–9.CrossRefPubMed Rockwood K, Mogilner A, Mitnitski A. Changes with age in the distribution of a frailty index. Mech Ageing Dev. 2004;125(7):517–9.CrossRefPubMed
32.
go back to reference Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323–36.CrossRefPubMed Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal. 2001;1:323–36.CrossRefPubMed
33.
go back to reference Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index. J Am Geriatr Soc. 2010;58(2):318–23.CrossRefPubMed Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index. J Am Geriatr Soc. 2010;58(2):318–23.CrossRefPubMed
34.
go back to reference Bennett S, Song X, Mitnitski A, Rockwood K. A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study. Age Ageing. 2013;42(3):372–7.CrossRefPubMed Bennett S, Song X, Mitnitski A, Rockwood K. A limit to frailty in very old, community-dwelling people: a secondary analysis of the Chinese longitudinal health and longevity study. Age Ageing. 2013;42(3):372–7.CrossRefPubMed
35.
go back to reference Wellens NI, Deschodt M, Flamaing J, Moons P, Boonen S, Boman X, et al. First-generation versus third-generation comprehensive geriatric assessment instruments in the acute hospital setting: a comparison of the Minimum Geriatric Screening Tools (MGST) and the interRAI Acute Care (interRAI AC). J Nutr Health Aging. 2011;15(8):638–44.CrossRefPubMed Wellens NI, Deschodt M, Flamaing J, Moons P, Boonen S, Boman X, et al. First-generation versus third-generation comprehensive geriatric assessment instruments in the acute hospital setting: a comparison of the Minimum Geriatric Screening Tools (MGST) and the interRAI Acute Care (interRAI AC). J Nutr Health Aging. 2011;15(8):638–44.CrossRefPubMed
36.
go back to reference Armstrong JJ, Stolee P, Hirdes JP, Poss JW. Examining three frailty conceptualizations in their ability to predict negative outcomes for home-care clients. Age Ageing. 2010;39(6):755–8.CrossRefPubMed Armstrong JJ, Stolee P, Hirdes JP, Poss JW. Examining three frailty conceptualizations in their ability to predict negative outcomes for home-care clients. Age Ageing. 2010;39(6):755–8.CrossRefPubMed
Metadata
Title
Derivation of a frailty index from the interRAI acute care instrument
Authors
Ruth E Hubbard
Nancye M Peel
Mayukh Samanta
Leonard C Gray
Brant E Fries
Arnold Mitnitski
Kenneth Rockwood
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2015
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-015-0026-z

Other articles of this Issue 1/2015

BMC Geriatrics 1/2015 Go to the issue