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Open Access 01-12-2019 | Colonoscopy | Research article

Improvement of Asia-Pacific colorectal screening score and evaluation of its use combined with fecal immunochemical test

Authors: Xu-xia He, Si-yi Yuan, Wen-bin Li, Hong Yang, Wen Ji, Zhi-qiang Wang, Jian-yu Hao, Chuan Chen, Wei-qing Chen, Ying-xin Gao, Ling-bo Li, Kai-liang Cheng, Jia-ming Qian, Li Wang, Jing-nan Li

Published in: BMC Gastroenterology | Issue 1/2019

Abstract

Background

The Asia-Pacific Colorectal Screening (APCS) score is effective to screen high-risk groups of advanced colorectal neoplasia (ACN) patients but needs revising and can be combined with the fecal immunochemical test (FIT). This paper aimed to improve the APCS score and evaluate its use with the FIT in stratifying the risk of ACN.

Methods

This prospective and multicenter study enrolled 955 and 1201 asymptomatic Chinese participants to form the derivation and validation set, respectively. Participants received the risk factor questionnaire, colonoscopy and FIT. Multiple logistic regression was applied, and C-statistic, sensitivity and negative predictive values (NPVs) were used to compare the screening efficiency.

Results

A modified model was developed incorporating age, body mass index (BMI), family history, diabetes, smoking and drinking as risk factors, stratifying subjects into average risk (AR) or high risk (HR). In the validation set, the HR tier group had a 3.4-fold (95% CI 1.8–6.4) increased risk for ACN. The C-statistic for the modified score was 0.69 ± 0.04, and 0.67 ± 0.04 for the original score. The sensitivity of the modified APCS score combined with FIT for screening ACN high-risk cohorts was 76.7% compared with 36.7% of FIT alone and 70.0% of the modified APCS score alone. The NPVs of the modified score combined with FIT for ACN were 98.0% compared with 97.0% of FIT alone and 97.9% of the modified APCS score alone.

Conclusions

The modified score and its use with the FIT are efficient in selecting the HR group from a Chinese asymptomatic population.

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Title: Improvement of Asia-Pacific colorectal screening score and evaluation of its use combined with fecal immunochemical test
Authors: Xu-xia He
Si-yi Yuan
Wen-bin Li
Hong Yang
Wen Ji
Zhi-qiang Wang
Jian-yu Hao
Chuan Chen
Wei-qing Chen
Ying-xin Gao
Ling-bo Li
Kai-liang Cheng
Jia-ming Qian
Li Wang
Jing-nan Li
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Colonoscopy
Colorectal Cancer
Colorectal Cancer
Published in: BMC Gastroenterology / Issue 1/2019
Electronic ISSN: 1471-230X
DOI: https://doi.org/10.1186/s12876-019-1146-2

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