Published in:
Open Access
01-12-2019 | Fatty Liver | Research article
Curcumin and inflammation in non-alcoholic fatty liver disease: a randomized, placebo controlled clinical trial
Authors:
Saeede Saadati, Amir Sadeghi, Asieh Mansour, Zahra Yari, Hossein Poustchi, Mehdi Hedayati, Behzad Hatami, Azita Hekmatdoost
Published in:
BMC Gastroenterology
|
Issue 1/2019
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Abstract
Background
The aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD).
Methods
Fifty patients with NAFLD were randomized to receive lifestyle modification advice plus either 1500 mg curcumin or the same amount of placebo for 12 weeks.
Results
Curcumin supplementation was associated with significant decrease in hepatic fibrosis (p < 0.001), and nuclear factor-kappa B activity (p < 0.05) as compared with the baseline. Hepatic steatosis and serum level of liver enzymes, and tumor necrosis-α (TNF-α) significantly reduced in both groups (p < 0.05). None of the changes were significantly different between two groups.
Conclusion
Our results indicated that curcumin supplementation plus lifestyle modification is not superior to lifestyle modification alone in amelioration of inflammation.