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BMC Gastroenterology
Published in: BMC Gastroenterology 1/2015

Open Access 01-12-2015 | Research article

A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population

Authors: Jing Chen, Wei Wang, Xiaoguang Li, Jie Xu

Published in: BMC Gastroenterology | Issue 1/2015

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Abstract

Background

Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and infection susceptibility of Hepatitis B Virus (HBV) in Asian population, especially in Chinese population by meta-analysis.

Methods

Search the relevant published papers and perform meta-analysis respectively on IL28B (rs12979860 and rs8099917) in Asian population and Chinese population under an additive genetic model by STATA11.0.

Results

The pooled odds ratios (OR) of rs12979860 are 0.79 (95% CI, 0.53-1.18; P = 0.25, I2 = 63.2%) and 1.62 (95% CI, 1.04-2.51; P = 0.033, I2 = 54.3%) respectively in Asian population and Chinese population analysis. The pooled OR of rs8099917 are 1.05 (95% CI, 0.93-1.19; P = 0.44, I2 = 43.3%) and 0.97 (95% CI, 0.84-1.23; P = 0.726, I2 = 15.6%) respectively in Asian population and Chinese population analysis.

Conclusion

Our study demonstrated that T allele of rs12979680 can increase the risk of HBV infection in Chinese population but not Asian population under an additive genetic model. There is no association between rs8099917 and HBV infection in Chinese population and Asian population.
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Metadata
Title
A meta-analysis of the association between IL28B polymorphisms and infection susceptibility of hepatitis B virus in Asian population
Authors
Jing Chen
Wei Wang
Xiaoguang Li
Jie Xu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2015
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-015-0286-2

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Reviewer acknowledgement

BMC Gastroenterology reviewer acknowledgement 2014

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