Skip to main content
Top
Published in: BMC Primary Care 1/2017

Open Access 01-12-2017 | Research article

Factors associated with general practitioners’ awareness of depression in primary care patients with heart failure: baseline-results from the observational RECODE-HF study

Authors: Marion Eisele, Anja Rakebrandt, Sigrid Boczor, Agata Kazek, Nadine Pohontsch, Magdalena Okolo-Kulak, Eva Blozik, Jens-Martin Träder, Stefan Störk, Christoph Herrmann-Lingen, Martin Scherer, for the RECODE Study Group

Published in: BMC Primary Care | Issue 1/2017

Login to get access

Abstract

Background

Depression is more prevalent in patients with heart failure (HF) than in those without, but its detection is complicated by the symptom overlap between the two diseases. General practitioners (GPs) are the first point of contact for patients with HF. Therefore, this study aims to investigate GPs’ awareness of depression in their HF patients and factors associated with this awareness.

Methods

In this cross-sectional, observational study 3224 primary care patients with HF were screened for depressive symptomatology using an algorithm based on the Hospital Anxiety and Depression Scale, the 9-item subscale on Depression of the Patient Health Questionnaire, and selected items from the PROMIS Depression and Anxiety scales. The 272 GPs of all patients involved in the study were interviewed by telephone regarding their patients’ somatic and psychological comorbidities. The awareness rates of depressive symptomatology by the patients’ GPs are analyzed using descriptive statistics. Logistic regression analyses are applied to investigate the patient- and GP-based factors associated with the GPs’ awareness of depressive symptomatology.

Results

GPs were aware of their patients’ depressive symptomatology in 35% of all cases. Factors associated with the awareness of depressive symptomatology were: higher patient education levels, a history of depression known to the GP, GP-consultations due to emotional distress within the last 6 months, a higher frequency of GP-contacts within the last 6 months, a higher New York Heart Association (NYHA) classification and more severe depressive symptomatology. The GPs’ characteristics, including further education in psychology/psychiatry, were not associated with GP awareness.

Conclusions

Many aspects, including the definition of awareness and the practical issues in primary care, may contribute to the unexpectedly low awareness rates of depressive symptomatology in HF patients in primary care. Awareness rates might increase, if GPs encouraged their patients to talk about emotional distress, held detailed medical interviews including a patient’s history of depression and payed special attention to HF patients with low education levels. However, it remains to be investigated whether GPs’ judgement of depressive symptomatology is a better or worse indicator for the future prognosis and quality of life of HF patients than psychiatry based diagnostic criteria.
Literature
1.
go back to reference Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation. 2005;112:e154–235.CrossRefPubMed Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation. 2005;112:e154–235.CrossRefPubMed
2.
go back to reference Moraska AR, Chamberlain AM, Shah ND, Vickers KS, Rummans TA, Dunlay SM, et al. Depression, Healthcare Utilization, and Death in Heart Failure A Community Study. Circ Heart Fail. 2013;6:387–94.CrossRefPubMedPubMedCentral Moraska AR, Chamberlain AM, Shah ND, Vickers KS, Rummans TA, Dunlay SM, et al. Depression, Healthcare Utilization, and Death in Heart Failure A Community Study. Circ Heart Fail. 2013;6:387–94.CrossRefPubMedPubMedCentral
3.
go back to reference Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Lond Engl. 2015;386:743–800. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Lond Engl. 2015;386:743–800.
4.
go back to reference Scherer M, Himmel W, Stanske B, Scherer F, Koschack J, Kochen MM, et al. Psychological distress in primary care patients with heart failure: a longitudinal study. Br J Gen Pr. 2007;57:801–7. Scherer M, Himmel W, Stanske B, Scherer F, Koschack J, Kochen MM, et al. Psychological distress in primary care patients with heart failure: a longitudinal study. Br J Gen Pr. 2007;57:801–7.
5.
go back to reference Scherer M, Stanske B, Wetzel D, Koschack J, Kochen MM, Herrmann-Lingen C. Psychosocial Co-Symptoms in Primary Care Patients with Heart Failure [Psychische Kosymptomatik von hausärztlichen Patienten mit Herzinsuffizienz]. Herz Kardiovaskuläre Erkrank. 2006;31:347–54.CrossRef Scherer M, Stanske B, Wetzel D, Koschack J, Kochen MM, Herrmann-Lingen C. Psychosocial Co-Symptoms in Primary Care Patients with Heart Failure [Psychische Kosymptomatik von hausärztlichen Patienten mit Herzinsuffizienz]. Herz Kardiovaskuläre Erkrank. 2006;31:347–54.CrossRef
6.
go back to reference Hunt SA. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2005;46:e1–82.CrossRefPubMed Hunt SA. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol. 2005;46:e1–82.CrossRefPubMed
7.
go back to reference Juenger J, Schellberg D, Kraemer S, Haunstetter A, Zugck C, Herzog W, et al. Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables. Heart. 2002;87:235–41.CrossRefPubMedPubMedCentral Juenger J, Schellberg D, Kraemer S, Haunstetter A, Zugck C, Herzog W, et al. Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables. Heart. 2002;87:235–41.CrossRefPubMedPubMedCentral
8.
go back to reference Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, et al. Age, functional capacity, and health-related quality of life in patients with heart failure. J Card Fail. 2004;10:368–73.CrossRefPubMed Masoudi FA, Rumsfeld JS, Havranek EP, House JA, Peterson ED, Krumholz HM, et al. Age, functional capacity, and health-related quality of life in patients with heart failure. J Card Fail. 2004;10:368–73.CrossRefPubMed
9.
go back to reference Cully JA, Jimenez DE, Ledoux TA, Deswal A. Recognition and Treatment of Depression and Anxiety Symptoms in Heart Failure. Prim Care Companion J Clin Psychiatry. 2009;11:103–9.CrossRefPubMedPubMedCentral Cully JA, Jimenez DE, Ledoux TA, Deswal A. Recognition and Treatment of Depression and Anxiety Symptoms in Heart Failure. Prim Care Companion J Clin Psychiatry. 2009;11:103–9.CrossRefPubMedPubMedCentral
10.
go back to reference Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–37.CrossRefPubMed Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ. Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol. 2006;48:1527–37.CrossRefPubMed
11.
go back to reference Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391–479.CrossRefPubMed Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391–479.CrossRefPubMed
12.
go back to reference Heart Failure Society of America. Executive Summary: HFSA 2010 Comprehensive Heart Failure Practice Guideline. J Card Fail. 2010;16:475–539.CrossRef Heart Failure Society of America. Executive Summary: HFSA 2010 Comprehensive Heart Failure Practice Guideline. J Card Fail. 2010;16:475–539.CrossRef
14.
go back to reference McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787–847.CrossRefPubMed McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33:1787–847.CrossRefPubMed
16.
go back to reference Health Quality Ontario. Screening and Management of Depression for Adults With Chronic Diseases: An Evidence-Based Analysis. Ont Health Technol Assess Ser. 2013;13:1–45. Health Quality Ontario. Screening and Management of Depression for Adults With Chronic Diseases: An Evidence-Based Analysis. Ont Health Technol Assess Ser. 2013;13:1–45.
17.
go back to reference Lépine JP, Gastpar M, Mendlewicz J, Tylee A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol. 1997;12:19–29.CrossRefPubMed Lépine JP, Gastpar M, Mendlewicz J, Tylee A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol. 1997;12:19–29.CrossRefPubMed
18.
go back to reference Mitchell AJ, Vaze A, Rao S. Clinical diagnosis of depression in primary care: a meta-analysis. Lancet. 2009;374:609–19.CrossRefPubMed Mitchell AJ, Vaze A, Rao S. Clinical diagnosis of depression in primary care: a meta-analysis. Lancet. 2009;374:609–19.CrossRefPubMed
19.
go back to reference Koenig HG. Recognition of Depression in Medical Patients With Heart Failure. Psychosomatics. 2007;48:338–47.CrossRefPubMed Koenig HG. Recognition of Depression in Medical Patients With Heart Failure. Psychosomatics. 2007;48:338–47.CrossRefPubMed
20.
go back to reference Eisele M, Blozik E, Störk S, Träder J-M, Herrmann-Lingen C, Scherer M. Recognition of depression and anxiety and their association with quality of life, hospitalization and mortality in primary care patients with heart failure – study protocol of a longitudinal observation study. BMC Fam Pract. 2013;14:180.CrossRefPubMedPubMedCentral Eisele M, Blozik E, Störk S, Träder J-M, Herrmann-Lingen C, Scherer M. Recognition of depression and anxiety and their association with quality of life, hospitalization and mortality in primary care patients with heart failure – study protocol of a longitudinal observation study. BMC Fam Pract. 2013;14:180.CrossRefPubMedPubMedCentral
21.
go back to reference Brauns H, Steinmann S. Educational reform in France, vol. 44. West-Germany and the United Kingdom: ZUMA-Nachrichten; 1999. p. 7–44. Brauns H, Steinmann S. Educational reform in France, vol. 44. West-Germany and the United Kingdom: ZUMA-Nachrichten; 1999. p. 7–44.
22.
go back to reference Cordes A, Herrmann-Lingen C, Büchner B, Hessel A. Repräsentative Normierung des ENRICHD-Social-Support-Instrument (ESSI) – Deutsche Version. Klin Diagn Eval. 2009:2, 16–32. Cordes A, Herrmann-Lingen C, Büchner B, Hessel A. Repräsentative Normierung des ENRICHD-Social-Support-Instrument (ESSI) – Deutsche Version. Klin Diagn Eval. 2009:2, 16–32.
23.
go back to reference Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52:69–77.CrossRefPubMed Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52:69–77.CrossRefPubMed
24.
go back to reference Herrmann-Lingen C, Buss U, Snaith R. HADS-D - Hospital Anxiety and Depression Scale - Deutsche Version: Deutsche Adaptation der Hospital Anxiety and Depression Scale (HADS). 2nd ed. Bern: Huber; 2005. Herrmann-Lingen C, Buss U, Snaith R. HADS-D - Hospital Anxiety and Depression Scale - Deutsche Version: Deutsche Adaptation der Hospital Anxiety and Depression Scale (HADS). 2nd ed. Bern: Huber; 2005.
25.
go back to reference Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. J Am Med Assoc. 1999;282:1737–44.CrossRef Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. J Am Med Assoc. 1999;282:1737–44.CrossRef
27.
go back to reference Löwe B, Gräfe K, Zipfel S, Witte S, Loerch B, Herzog W. Diagnosing ICD-10 depressive episodes: superior criterion validity of the Patient Health Questionnaire. Psychother Psychosom. 2004;73:386–90.CrossRefPubMed Löwe B, Gräfe K, Zipfel S, Witte S, Loerch B, Herzog W. Diagnosing ICD-10 depressive episodes: superior criterion validity of the Patient Health Questionnaire. Psychother Psychosom. 2004;73:386–90.CrossRefPubMed
28.
go back to reference Pilkonis PA, Choi SW, Reise SP, Stover AM, Riley WT, Cella D. Item Banks for Measuring Emotional Distress From the Patient-Reported Outcomes Measurement Information System (PROMIS®): Depression, Anxiety, and Anger. Assessment. 2011;18:263–83.CrossRefPubMedPubMedCentral Pilkonis PA, Choi SW, Reise SP, Stover AM, Riley WT, Cella D. Item Banks for Measuring Emotional Distress From the Patient-Reported Outcomes Measurement Information System (PROMIS®): Depression, Anxiety, and Anger. Assessment. 2011;18:263–83.CrossRefPubMedPubMedCentral
29.
go back to reference Choi SW, Reise SP, Pilkonis PA, Hays RD, Cella D. Efficiency of static and computer adaptive short forms compared to full-length measures of depressive symptoms. Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2010;19:125–36.CrossRef Choi SW, Reise SP, Pilkonis PA, Hays RD, Cella D. Efficiency of static and computer adaptive short forms compared to full-length measures of depressive symptoms. Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2010;19:125–36.CrossRef
30.
go back to reference Fischer HF, Klug C, Roeper K, Blozik E, Edelmann F, Eisele M, et al. Screening for mental disorders in heart failure patients using computer-adaptive tests. Qual Life Res. 2014;23:1609–18.CrossRefPubMed Fischer HF, Klug C, Roeper K, Blozik E, Edelmann F, Eisele M, et al. Screening for mental disorders in heart failure patients using computer-adaptive tests. Qual Life Res. 2014;23:1609–18.CrossRefPubMed
31.
go back to reference Wittchen H, Zaudig M, Fydrich T. Strukturiertes Klinisches Interview für DSM-IV. Göttingen: Hogrefe; 1997. Wittchen H, Zaudig M, Fydrich T. Strukturiertes Klinisches Interview für DSM-IV. Göttingen: Hogrefe; 1997.
32.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83.CrossRefPubMed
33.
go back to reference Graubner B. Deutsches Institut für Medizinische Dokumentation und Information (Köln). In: ICD-10-GM 2010 : Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. Köln: Deutscher Ärzte-Verlag. p. 2010. Graubner B. Deutsches Institut für Medizinische Dokumentation und Information (Köln). In: ICD-10-GM 2010 : Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme. Köln: Deutscher Ärzte-Verlag. p. 2010.
34.
go back to reference Schäfer I, von Leitner EC, Schön G, Koller D, Hansen H, Kolonko T, et al. Multimorbidity Patterns in the Elderly: A New Approach of Disease Clustering Identifies Complex Interrelations between Chronic Conditions. PLoS One. 2010;5:e15941.CrossRefPubMedPubMedCentral Schäfer I, von Leitner EC, Schön G, Koller D, Hansen H, Kolonko T, et al. Multimorbidity Patterns in the Elderly: A New Approach of Disease Clustering Identifies Complex Interrelations between Chronic Conditions. PLoS One. 2010;5:e15941.CrossRefPubMedPubMedCentral
35.
go back to reference Joling KJ, van Marwijk HWJ, Piek E, van der Horst HE, Penninx BW, Verhaak P, et al. Do GPs’ medical records demonstrate a good recognition of depression? A new perspective on case extraction. J Affect Disord. 2011;133:522–7.CrossRefPubMed Joling KJ, van Marwijk HWJ, Piek E, van der Horst HE, Penninx BW, Verhaak P, et al. Do GPs’ medical records demonstrate a good recognition of depression? A new perspective on case extraction. J Affect Disord. 2011;133:522–7.CrossRefPubMed
36.
go back to reference Thomas SA, Chapa DW, Friedmann E, Durden C, Ross A, Lee MCY, et al. Depression in Patients With Heart Failure: Prevalence, Pathophysiological Mechanisms, and Treatment. Crit Care Nurse. 2008;28:40–55.PubMed Thomas SA, Chapa DW, Friedmann E, Durden C, Ross A, Lee MCY, et al. Depression in Patients With Heart Failure: Prevalence, Pathophysiological Mechanisms, and Treatment. Crit Care Nurse. 2008;28:40–55.PubMed
37.
go back to reference Schumann I, Schneider A, Kantert C, Löwe B, Linde K. Physicians’ attitudes, diagnostic process and barriers regarding depression diagnosis in primary care: a systematic review of qualitative studies. Fam Pract. 2011. doi:10.1093/fampra/cmr092. Schumann I, Schneider A, Kantert C, Löwe B, Linde K. Physicians’ attitudes, diagnostic process and barriers regarding depression diagnosis in primary care: a systematic review of qualitative studies. Fam Pract. 2011. doi:10.​1093/​fampra/​cmr092.
39.
go back to reference Van Rijswijk E, van Hout H, van de Lisdonk E, Zitman F, van Weel C. Barriers in recognising, diagnosing and managing depressive and anxiety disorders as experienced by Family Physicians; a focus group study. BMC Fam Pract. 2009;10 doi:10.1186/1471-2296-10-52. Van Rijswijk E, van Hout H, van de Lisdonk E, Zitman F, van Weel C. Barriers in recognising, diagnosing and managing depressive and anxiety disorders as experienced by Family Physicians; a focus group study. BMC Fam Pract. 2009;10 doi:10.​1186/​1471-2296-10-52.
40.
go back to reference Piek E, Nolen WA, van der Meer K, Joling KJ, Kollen BJ, Penninx BWJH, et al. Determinants of (non-)recognition of depression by general practitioners: Results of the Netherlands study of depression and anxiety. J Affect Disord. 2012;138:397–404.CrossRefPubMed Piek E, Nolen WA, van der Meer K, Joling KJ, Kollen BJ, Penninx BWJH, et al. Determinants of (non-)recognition of depression by general practitioners: Results of the Netherlands study of depression and anxiety. J Affect Disord. 2012;138:397–404.CrossRefPubMed
41.
go back to reference Menchetti M, Belvederi Murri M, Bertakis K, Bortolotti B, Berardi D. Recognition and treatment of depression in primary care: effect of patients’ presentation and frequency of consultation. J Psychosom Res. 2009;66:335–41.CrossRefPubMed Menchetti M, Belvederi Murri M, Bertakis K, Bortolotti B, Berardi D. Recognition and treatment of depression in primary care: effect of patients’ presentation and frequency of consultation. J Psychosom Res. 2009;66:335–41.CrossRefPubMed
42.
go back to reference Wittchen HU, Höfler M, Meister W. Prevalence and recognition of depressive syndromes in German primary care settings: poorly recognized and treated? Int Clin Psychopharmacol. 2001;16:121–35.CrossRefPubMed Wittchen HU, Höfler M, Meister W. Prevalence and recognition of depressive syndromes in German primary care settings: poorly recognized and treated? Int Clin Psychopharmacol. 2001;16:121–35.CrossRefPubMed
43.
go back to reference Piepenburg SM, Faller H, Gelbrich G, Störk S, Warrings B, Ertl G, et al. Comparative Potential of the 2-Item Versus the 9-Item Patient Health Questionnaire to Predict Death or Rehospitalization in Heart Failure. Circ Heart Fail. 2015;8:464–72.CrossRefPubMed Piepenburg SM, Faller H, Gelbrich G, Störk S, Warrings B, Ertl G, et al. Comparative Potential of the 2-Item Versus the 9-Item Patient Health Questionnaire to Predict Death or Rehospitalization in Heart Failure. Circ Heart Fail. 2015;8:464–72.CrossRefPubMed
44.
go back to reference Höfler M, Wittchen H-U. Why do primary care doctors diagnose depression when diagnostic criteria are not met? Int J Methods Psychiatr Res. 2000;9:110–20.CrossRef Höfler M, Wittchen H-U. Why do primary care doctors diagnose depression when diagnostic criteria are not met? Int J Methods Psychiatr Res. 2000;9:110–20.CrossRef
45.
go back to reference Thompson C, Kinmonth A, Stevens L, Pevele R, Stevens A, Ostler K, et al. Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial. Lancet. 2000;355:185–91.CrossRefPubMed Thompson C, Kinmonth A, Stevens L, Pevele R, Stevens A, Ostler K, et al. Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial. Lancet. 2000;355:185–91.CrossRefPubMed
Metadata
Title
Factors associated with general practitioners’ awareness of depression in primary care patients with heart failure: baseline-results from the observational RECODE-HF study
Authors
Marion Eisele
Anja Rakebrandt
Sigrid Boczor
Agata Kazek
Nadine Pohontsch
Magdalena Okolo-Kulak
Eva Blozik
Jens-Martin Träder
Stefan Störk
Christoph Herrmann-Lingen
Martin Scherer
for the RECODE Study Group
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Primary Care / Issue 1/2017
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/s12875-017-0641-1

Other articles of this Issue 1/2017

BMC Primary Care 1/2017 Go to the issue