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BMC Immunology
Published in: BMC Immunology 1/2021

01-12-2021 | Helminths | Research

The role of β2 integrin in dendritic cell migration during infection

Authors: Tarfa Altorki, Werner Muller, Andrew Brass, Sheena Cruickshank

Published in: BMC Immunology | Issue 1/2021

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Abstract

Background

Dendritic cells (DCs) play a key role in shaping T cell responses. To do this, DCs must be able to migrate to the site of the infection and the lymph nodes to prime T cells and initiate the appropriate immune response. Integrins such as β2 integrin play a key role in leukocyte adhesion, migration, and cell activation. However, the role of β2 integrin in DC migration and function in the context of infection-induced inflammation in the gut is not well understood. This study looked at the role of β2 integrin in DC migration and function during infection with the nematode worm Trichuris muris. Itgb2tm1Bay mice lacking functional β2 integrin and WT littermate controls were infected with T. muris and the response to infection and kinetics of the DC response was assessed.

Results

In infection, the lack of functional β2 integrin significantly reduced DC migration to the site of infection but not the lymph nodes. The lack of functional β2 integrin did not negatively impact T cell activation in response to T. muris infection.

Conclusions

This data suggests that β2 integrins are important in DC recruitment to the infection site potentially impacting the initiation of innate immunity but is dispensible for DC migration to lymph nodes and T cell priming in the context of T. muris infection.
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Metadata
Title
The role of β2 integrin in dendritic cell migration during infection
Authors
Tarfa Altorki
Werner Muller
Andrew Brass
Sheena Cruickshank
Publication date
01-12-2021
Publisher
BioMed Central
Keyword
Helminths
Published in
BMC Immunology / Issue 1/2021
Electronic ISSN: 1471-2172
DOI
https://doi.org/10.1186/s12865-020-00394-5

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