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Open Access 01-12-2020 | Chlamydia | Research article

Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases

Authors: Leonn Mendes Soares Pereira, Max Willy da Silva Madureira, Renata Bezerra Hermes de Castro, Isabella Nogueira Abreu, Simone Regina Souza da Silva Conde, Sâmia Demachki, Maisa Silva de Sousa, Maria Alice Freitas Queiroz, Andrea Nazaré M. Rangel da Silva, Sandra Souza Lima, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto

Published in: BMC Immunology | Issue 1/2020

Abstract

Background

The forkhead box protein 3 (FOXP3) transcription factor is one of the main markers of immunological suppression in different pathological profiles, and the presence of polymorphic variants may alter the gene expression of this factor. Despite descriptions of an association between the presence of the rs2232365 polymorphism and chronic diseases, the role of the sex variant in this context has not yet been elucidated, as the FOXP3 gene is located on the human sex chromosome X.

Results

To contribute to this topic, 323 women and 373 men were enrolled in the study, of which 101 were diagnosed with chronic viral liver diseases (39 women and 62 men), 67 with HTLV-1 infection (44 women and 23 men), 230 with coronary artery disease (91 women and 139 men) and 298 healthy and uninfected blood donors (149 women and men). They were genotyped for the rs2232365 polymorphism. The rs2232365 polymorphism was associated with clinical and pathological aspects and biomarkers of viral infections only in men, with functional differences between different infections.

Conclusions

A relationship is suggested between sex and FOXP3 rs2232365 polymorphism, resulting in different biological repercussions.

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Title: Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases
Authors: Leonn Mendes Soares Pereira
Max Willy da Silva Madureira
Renata Bezerra Hermes de Castro
Isabella Nogueira Abreu
Simone Regina Souza da Silva Conde
Sâmia Demachki
Maisa Silva de Sousa
Maria Alice Freitas Queiroz
Andrea Nazaré M. Rangel da Silva
Sandra Souza Lima
Marluísa de Oliveira Guimarães Ishak
Ricardo Ishak
Antonio Carlos Rosário Vallinoto
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Chlamydia
Published in: BMC Immunology / Issue 1/2020
Electronic ISSN: 1471-2172
DOI: https://doi.org/10.1186/s12865-020-00387-4

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Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases

Abstract

Background

Results

Conclusions

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