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Open Access 01-12-2015 | Research article

Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages

Authors: Patricia Espinosa-Cueto, Marina Escalera-Zamudio, Alejandro Magallanes-Puebla, Luz María López-Marín, Erika Segura-Salinas, Raúl Mancilla

Published in: BMC Immunology | Issue 1/2015

Abstract

Background

Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines.

Results

In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ).

Conclusions

These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria.

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Title: Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages
Authors: Patricia Espinosa-Cueto
Marina Escalera-Zamudio
Alejandro Magallanes-Puebla
Luz María López-Marín
Erika Segura-Salinas
Raúl Mancilla
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Immunology / Issue 1/2015
Electronic ISSN: 1471-2172
DOI: https://doi.org/10.1186/s12865-015-0102-3

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Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages

Abstract

Background

Results

Conclusions

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Abstract

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