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Published in: Journal of Ophthalmic Inflammation and Infection 1/2018

Open Access 01-12-2018 | Brief report

Swept-source OCT in patients with multiple evanescent white dot syndrome

Authors: Felipe Pereira, Luiz H. Lima, Alexandre Gomes B. de Azevedo, Claudio Zett, Michel E. Farah, Rubens Belfort Jr

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2018

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Abstract

Background

Swept-source optical coherence tomography (SS-OCT) has a higher scanning rate and longer wavelength in comparison with spectral-domain OCT (SD-OCT), allowing an improved imaging of retinal vascular plexuses and choriocapillaris. The present two patients diagnosed with multiple evanescent white dot syndrome (MEWDS) underwent fundus autofluorescence (FAF), en-face SS-OCT, and SS-OCT angiography (OCTA) imaging, and its features were described and correlated.

Results

The clinical and imaging findings of both cases were consistent with the diagnosis of MEWDS. Color fundus photograph revealed subtle deep retinal white spots in the posterior pole and around the optic disk. FAF showed several hyperautofluorescent lesions corresponding topographically to the subtle deep retinal white lesions observed on color fundus photographs. Cross-sectional SS-OCT showed disruption of the ellipsoid zone (EZ) within the macular area in all study patients. En-face SS-OCT at the level of the outer retina showed lower reflectivity correspondent to the diffuse attenuation due to the EZ disruption on cross-sectional OCT. SS-OCTA demonstrated flow preservation within the retinal vasculature and choriocapillaris.

Conclusions

SS-OCT imaging allows a better visualization of the choriocapillaris, and its normal appearance in MEWDS may suggest that the outer retina and photoreceptors represent the primary site of inflammation.
Literature
1.
go back to reference Jampol LM, Sieving PA, Pugh D, Fishman GA, Gilbert H (1984) Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol 102:671–674CrossRef Jampol LM, Sieving PA, Pugh D, Fishman GA, Gilbert H (1984) Multiple evanescent white dot syndrome. I. Clinical findings. Arch Ophthalmol 102:671–674CrossRef
3.
go back to reference Cahuzac A, Wolff B, Mathis T, Errera MH, Sahel JA, Mauget-Faÿsse M (2017) Multimodal imaging findings in ‘hyper-early’ stage MEWDS. Br J Ophthalmol 101:1381–1385CrossRef Cahuzac A, Wolff B, Mathis T, Errera MH, Sahel JA, Mauget-Faÿsse M (2017) Multimodal imaging findings in ‘hyper-early’ stage MEWDS. Br J Ophthalmol 101:1381–1385CrossRef
4.
go back to reference Gal-Or O, Priel E, Rosenblatt I, Shulman S, Kramer M (2017) Multimodal imaging in an unusual cluster of multiple evanescent white dot syndrome. J Ophthalmol 2017:7535320PubMedPubMedCentral Gal-Or O, Priel E, Rosenblatt I, Shulman S, Kramer M (2017) Multimodal imaging in an unusual cluster of multiple evanescent white dot syndrome. J Ophthalmol 2017:7535320PubMedPubMedCentral
5.
go back to reference Dell’omo R, Wong R, Marino M, Konstantopoulou K, Pavesio C (2010) Relationship between different fluorescein and indocyanine green angiography features in multiple evanescent white dot syndrome. Br J Ophthalmol 94:59–63CrossRef Dell’omo R, Wong R, Marino M, Konstantopoulou K, Pavesio C (2010) Relationship between different fluorescein and indocyanine green angiography features in multiple evanescent white dot syndrome. Br J Ophthalmol 94:59–63CrossRef
6.
go back to reference Pichi F, Srvivastava SK, Chexal S, Lembo A, Lima LH, Neri P et al (2016) En face optical coherence tomography and optical coherence tomography angiography of multiple evanescent white dot syndrome: new insights into pathogenesis. Retina 36:178–188CrossRef Pichi F, Srvivastava SK, Chexal S, Lembo A, Lima LH, Neri P et al (2016) En face optical coherence tomography and optical coherence tomography angiography of multiple evanescent white dot syndrome: new insights into pathogenesis. Retina 36:178–188CrossRef
7.
go back to reference Obana A, Kusumi M, Miki T (1996) Indocyanine green angiographic aspects of multiple evanescent white dot syndrome. Retina 16:97–104CrossRef Obana A, Kusumi M, Miki T (1996) Indocyanine green angiographic aspects of multiple evanescent white dot syndrome. Retina 16:97–104CrossRef
8.
go back to reference Yannuzzi NA, Swaminathan SS, Zheng F, Miller A, Gregori G, Davis JL et al (2017) Swept-source OCT angiography shows sparing of the choriocapillaris in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 48:69–74CrossRef Yannuzzi NA, Swaminathan SS, Zheng F, Miller A, Gregori G, Davis JL et al (2017) Swept-source OCT angiography shows sparing of the choriocapillaris in multiple evanescent white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 48:69–74CrossRef
9.
go back to reference Barteselli G, Bartsch DU, Weinreb RN, Camacho N, Nezgoda JT, Marvasti AH et al (2016) Real-time full-depth visualization of posterior ocular structures: comparison between full-depth imaging spectral domain optical coherence tomography and sweptsource optical coherence tomography. Retina 36:1153–1161CrossRef Barteselli G, Bartsch DU, Weinreb RN, Camacho N, Nezgoda JT, Marvasti AH et al (2016) Real-time full-depth visualization of posterior ocular structures: comparison between full-depth imaging spectral domain optical coherence tomography and sweptsource optical coherence tomography. Retina 36:1153–1161CrossRef
10.
go back to reference Huang Y, Zhang Q, Thorell MR, An L, Durbin MK, Laron M et al (2014) Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. Ophthalmic Surg Lasers Imaging Retina 45:382–389CrossRef Huang Y, Zhang Q, Thorell MR, An L, Durbin MK, Laron M et al (2014) Swept-source OCT angiography of the retinal vasculature using intensity differentiation-based optical microangiography algorithms. Ophthalmic Surg Lasers Imaging Retina 45:382–389CrossRef
11.
go back to reference Freund KB, Mrejen S, Jung J, Yannuzzi LA, Boon CJ (2013) Increased fundus autofluorescence related to outer retinal disruption. JAMA Ophthalmol 131:1645–1649CrossRef Freund KB, Mrejen S, Jung J, Yannuzzi LA, Boon CJ (2013) Increased fundus autofluorescence related to outer retinal disruption. JAMA Ophthalmol 131:1645–1649CrossRef
12.
go back to reference Hashimoto H, Kishi S (2015) Ultra-wide-field fundus autofluorescence in multiple evanescent white dot syndrome. Am J Ophthalmol 159:698–706CrossRef Hashimoto H, Kishi S (2015) Ultra-wide-field fundus autofluorescence in multiple evanescent white dot syndrome. Am J Ophthalmol 159:698–706CrossRef
13.
go back to reference Fiore T, Iaccheri B, Cerquaglia A, Lupidi M, Torroni G, Fruttini D et al (2016) Outer retinal and choroidal evaluation in multiple evanescent white dot syndrome (MEWDS): an enhanced depth imaging optical coherence tomography study. Ocul Immunol Inflamm 11:1–7 Fiore T, Iaccheri B, Cerquaglia A, Lupidi M, Torroni G, Fruttini D et al (2016) Outer retinal and choroidal evaluation in multiple evanescent white dot syndrome (MEWDS): an enhanced depth imaging optical coherence tomography study. Ocul Immunol Inflamm 11:1–7
14.
go back to reference De bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel JA et al (2014) En-face spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome. J Ophthalmol 2014 2014:928028 De bats F, Wolff B, Vasseur V, Affortit A, Kodjikian L, Sahel JA et al (2014) En-face spectral-domain optical coherence tomography findings in multiple evanescent white dot syndrome. J Ophthalmol 2014 2014:928028
15.
go back to reference Nozaki M, Hamada S, Kimura M, Yoshida M, Ogura Y (2016) Value of OCT angiography in the diagnosis of choroidal neovascularization complicating multiple evanescence white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 47:580–584CrossRef Nozaki M, Hamada S, Kimura M, Yoshida M, Ogura Y (2016) Value of OCT angiography in the diagnosis of choroidal neovascularization complicating multiple evanescence white dot syndrome. Ophthalmic Surg Lasers Imaging Retina 47:580–584CrossRef
16.
go back to reference Aoyagi R, Hayashi T, Masai A, Mitooka K, Gekka T, Kozaki K et al (2012) Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom 95:212–217CrossRef Aoyagi R, Hayashi T, Masai A, Mitooka K, Gekka T, Kozaki K et al (2012) Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom 95:212–217CrossRef
17.
go back to reference Thomas BJ, Albini TA, Flynn HW Jr (2013) Multiple evanescent white dot syndrome: multimodal imaging and correlation with proposed pathophysiology. Ophthalmic Surg Lasers Imaging Retina 44:584–587CrossRef Thomas BJ, Albini TA, Flynn HW Jr (2013) Multiple evanescent white dot syndrome: multimodal imaging and correlation with proposed pathophysiology. Ophthalmic Surg Lasers Imaging Retina 44:584–587CrossRef
18.
go back to reference Marsiglia M, Gallego-Pinazo R, Cunha de Souza E, Munk MR, Yu S, Mrejen S et al (2016) Expanded clinical spectrum of multiple evanescent white dot syndrome with multimodal imaging. Retina 36:64–74CrossRef Marsiglia M, Gallego-Pinazo R, Cunha de Souza E, Munk MR, Yu S, Mrejen S et al (2016) Expanded clinical spectrum of multiple evanescent white dot syndrome with multimodal imaging. Retina 36:64–74CrossRef
19.
go back to reference Labriola LT, Legarreta AD, Legarreta JE, Nadler Z, Gallagher D, Hammer DX et al (2016) Imaging with multimodal adaptive-optics optical coherence tomography in multiple evanescent white dot syndrome: the structure and functional relationship. Retin Cases Brief Rep 10:302–309PubMedPubMedCentral Labriola LT, Legarreta AD, Legarreta JE, Nadler Z, Gallagher D, Hammer DX et al (2016) Imaging with multimodal adaptive-optics optical coherence tomography in multiple evanescent white dot syndrome: the structure and functional relationship. Retin Cases Brief Rep 10:302–309PubMedPubMedCentral
Metadata
Title
Swept-source OCT in patients with multiple evanescent white dot syndrome
Authors
Felipe Pereira
Luiz H. Lima
Alexandre Gomes B. de Azevedo
Claudio Zett
Michel E. Farah
Rubens Belfort Jr
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Journal of Ophthalmic Inflammation and Infection / Issue 1/2018
Electronic ISSN: 1869-5760
DOI
https://doi.org/10.1186/s12348-018-0159-2

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