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Environmental Health and Preventive Medicine
Published in: Environmental Health and Preventive Medicine 1/2020

Open Access 01-12-2020 | Colorectal Cancer | Research article

The relationship between metabolic syndrome and the incidence of colorectal cancer

Authors: JungHyun Lee, Kun Sei Lee, Hyeongsu Kim, Hyoseon Jeong, Min-Jung Choi, Hai-Won Yoo, Tae-Hwa Han, Hyunjung Lee

Published in: Environmental Health and Preventive Medicine | Issue 1/2020

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Abstract

Objectives

This study evaluated the incidence of colorectal cancer (CRC) according to the number of metabolic syndrome (MetS) components.

Methods

Using health checkup and insurance claims data of 6,365,409 subjects, the occurrence of CRC according to stage of MetS by sex was determined from the date of the health checkup in 2009 until December 31, 2018.

Results

Cumulative incidence rates (CIR) of CRC in men and women was 3.9 and 2.8 per 1000 (p < 0.001), respectively. CIR of CRC for the normal, pre-MetS, and MetS groups in men was 2.6, 3.9, and 5.5 per 1000 (p < 0.001) and CIR in women was 2.1, 2.9, and 4.5 per 1000 (p < 0.001), respectively. Compared with the normal group, the hazard ratio (HR) of CRC for the pre-MetS group was 1.25 (95% CI 1.17–1.33) in men and 1.09 (95% CI 1.02–1.17) in women, and the HR of CRC for the MetS group was 1.54 (95% CI 1.43–1.65) in men and 1.39 (95% CI 1.26–1.53) in women after adjustment.

Conclusions

We found that MetS is a risk factor for CRC in this study. Therefore, the prevention and active management of MetS would contribute to the prevention of CRC.
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Metadata
Title
The relationship between metabolic syndrome and the incidence of colorectal cancer
Authors
JungHyun Lee
Kun Sei Lee
Hyeongsu Kim
Hyoseon Jeong
Min-Jung Choi
Hai-Won Yoo
Tae-Hwa Han
Hyunjung Lee
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Environmental Health and Preventive Medicine / Issue 1/2020
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI
https://doi.org/10.1186/s12199-020-00845-w

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