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Open Access 01-12-2019 | CADASIL | Research article

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Authors: Jingjing Su, Mengxing Wang, Shiyu Ban, Liang Wang, Xin Cheng, Fengchun Hua, Yuping Tang, Houguang Zhou, Yu Zhai, Xiaoxia Du, Jianren Liu

Published in: The Journal of Headache and Pain | Issue 1/2019

Abstract

Background

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with structural brain changes such as lacunar lesion burden, normalized brain volume, and anterior thalamic radiation lesions, but changes in resting-state functional brain activity in patients with CADASIL have not been reported.

Methods

This study used resting-state functional magnetic resonance imaging (fMRI) to measure the amplitude of low-frequency fluctuation (ALFF) in 22 patients with CADASIL and 44 healthy matched controls. A seed-based functional connectivity (FC) analysis was used to investigate whether the dysfunctional areas identified by ALFF analysis exhibited abnormal FC with other brain areas. Pearson’s correlation analysis was used to detect correlations between the ALFF z-score of abnormal brain areas and clinical scores in patients with CADASIL.

Results

Patients with CADASIL exhibited significantly lower ALFF values in the right precuneus and cuneus (Pcu/CU) and higher ALFF values in the bilateral superior frontal gyrus (SFG) and left cerebellar anterior and posterior lobes compared with controls. Patients with CADASIL showed weaker FC between the areas with abnormal ALFF (using peaks in the left and right SFG and the right Pcu/CU) and other brain areas. Importantly, the ALFF z-scores for the left and right SFG were negatively associated with cognitive performance, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment scores (MoCA), respectively, whereas those of the right Pcu/CU were positively correlated with the MMSE score.

Conclusions

This preliminary study provides evidence for changes in ALFF of the right Pcu/CU, bilateral SFG and left cerebellar anterior and posterior lobes, and associations between ALFF values for abnormal brain areas and cognitive performance in patients with CADASIL. Therefore, spontaneous brain activity may be a novel imaging biomarker of cognitive impairment in this population.

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Title: Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL
Authors: Jingjing Su
Mengxing Wang
Shiyu Ban
Liang Wang
Xin Cheng
Fengchun Hua
Yuping Tang
Houguang Zhou
Yu Zhai
Xiaoxia Du
Jianren Liu
Publication date: 01-12-2019
Publisher: Springer Milan
Keyword: CADASIL
Published in: The Journal of Headache and Pain / Issue 1/2019
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-019-0982-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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