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Critical Care
Published in: Critical Care 4/2010

01-08-2010 | Letter

Understanding immune dysfunctions in sepsis patients

Authors: Eduardo López-Collazo, Vanesa Gómez-Piña, Francisco Arnalich

Published in: Critical Care | Issue 4/2010

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Excerpt

We read with interest the article by Gogos and colleagues in a previous issue of Critical Care reporting that there are major differences in the early status of the innate and adaptative immune responses between sepsis and severe sepsis/shock in relation to the underlying type of infection [1]. In patients with acute pyelonephritis and intraabdominal infection, expression of HLA-DR on monocytes was significantly decreased among patients with severe sepsis/shock compared with among patients only suffering sepsis. This difference was related to an unfavourable outcome in patients with acute pyelonephritis. …
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Literature
1.
Gogos C, Kotsaki A, Pelekanou A, Giannikopoulos G, Vaki I, Maravitsa P, Adamis S, Alexiou Z, Andrianopoulos G, Antonopoulou A, Athanassia S, Baziaka F, Charalambous A, Christodoulou S, Dimopoulou I, Floros I, Giannitsioti E, Gkanas P, Ioakeimidou A, Kanellakopoulou K, Karabela N, Karagianni V, Katsarolis I, Kontopithari G, Kopterides P, Koutelidakis I, Koutoukas P, Kranidioti H, Lignos M, Louis K, et al.: Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit Care 2010, 14: R96. 10.1186/cc9031PubMedCentralCrossRefPubMed
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Cavaillon JM, Adib-Conquy M: Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit Care 2006, 10: 233. 10.1186/cc5055PubMedCentralCrossRefPubMed
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Biswas SK, Lopez-Collazo E: Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 2009, 30: 475-487. 10.1016/j.it.2009.07.009CrossRefPubMed
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Escoll P, del Fresno C, Garcia L, Vallés G, Lendinez MJ, Arnalich F, López-Collazo E: Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. Biochem Biophys Res Commun 2003, 311: 465-472. 10.1016/j.bbrc.2003.10.019CrossRefPubMed
5.
Monneret G, Venet F, Pachot A, Lepape A: Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony. Mol Med 2008, 14: 64-78. 10.2119/2007-00102.MonneretPubMedCentralCrossRefPubMed
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Levy M, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS. International sepsis definitions conference. Crit Care Med 2003, 31: 1250-1256. 10.1097/01.CCM.0000050454.01978.3BCrossRefPubMed
Metadata
Title
Understanding immune dysfunctions in sepsis patients
Authors
Eduardo López-Collazo
Vanesa Gómez-Piña
Francisco Arnalich
Publication date
01-08-2010
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2010
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9202

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