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Open Access 01-04-2010 | Research

Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study

Authors: Oliver Karam, Marisa Tucci, Scot T Bateman, Thierry Ducruet, Philip C Spinella, Adrienne G Randolph, Jacques Lacroix

Published in: Critical Care | Issue 2/2010

Abstract

Introduction

Transfusion is a common treatment in pediatric intensive care units (PICUs). Studies in adults suggest that prolonged storage of red blood cell units is associated with worse clinical outcome. No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children.

Methods

Prospective, observational study conducted in 30 North American centers, in consecutive patients aged <18 years with a stay ≥ 48 hours in a PICU. The primary outcome measure was the incidence of multiple organ dysfunction syndrome after transfusion. The secondary outcomes were 28-day mortality and PICU length of stay. Odds ratios were adjusted for gender, age, number of organ dysfunctions at admission, total number of transfusions, and total dose of transfusion, using a multiple logistic regression model.

Results

The median length of storage was 14 days in 296 patients with documented length of storage. For patients receiving blood stored ≥ 14 days, the adjusted odds ratio for an increased incidence of multiple organ dysfunction syndrome was 1.87 (95% CI 1.04;3.27, P = 0.03). There was also a significant difference in the total PICU length of stay (adjusted median difference +3.7 days, P < 0.001) and no significant change in mortality.

Conclusions

In critically ill children, transfusion of red blood cell units stored for ≥ 14 days is independently associated with an increased occurrence of multiple organ dysfunction syndrome and prolonged PICU stay.

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Title: Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
Authors: Oliver Karam
Marisa Tucci
Scot T Bateman
Thierry Ducruet
Philip C Spinella
Adrienne G Randolph
Jacques Lacroix
Publication date: 01-04-2010
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2010
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc8953

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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