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Critical Care
Published in: Critical Care 1/2009

01-03-2009 | Poster presentation

Asymmetric and symmetric dimethylarginines: metabolism and role in severe sepsis

Authors: M Umbrello, F Colombo Pavini, L Bolgiaghi, E Carloni, F Rapido, M Gomarasca, E D'Angelo, G Iapichino

Published in: Critical Care | Special Issue 1/2009

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Excerpt

Asymmetric dimethylarginines (ADMA) and symmetric dimethylarginines (SDMA) are markers of protein breakdown; both compete with arginine for cellular transport and are excreted in urine. In addition, ADMA is a nonselective inhibitor of NO synthase, and is also metabolized by dimethylarginine-dimethylaminohydrolase (DDAH), a specific hydrolase whose activity in stress is controversial [1]. While the ADMA increase is associated with adverse events in many critical conditions, little attention has been focused on the role of SDMA [2]. …
Literature
1.
Zoccali C, et al.: Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections. Nephrol Dial Transplant 2007, 22: 801-806. 10.1093/ndt/gfl719PubMedCrossRef
2.
O'Dwyer MJ, et al.: Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. Crit Care 2006, 10: R139. 10.1186/cc5053PubMedCrossRef
Metadata
Title
Asymmetric and symmetric dimethylarginines: metabolism and role in severe sepsis
Authors
M Umbrello
F Colombo Pavini
L Bolgiaghi
E Carloni
F Rapido
M Gomarasca
E D'Angelo
G Iapichino
Publication date
01-03-2009
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2009
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc7525

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