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Published in: Critical Care 2/2007

01-04-2007 | Commentary

Acute stroke: we have the treatments and we have the evidence – we need to use them

Authors: Terence J Quinn, Jesse Dawson, Kennedy R Lees

Published in: Critical Care | Issue 2/2007

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Abstract

Despite huge global burden, stroke disease has traditionally received little attention in the general medical press. We review a series of four acute stroke research articles published in a themed issue of the Lancet. Claiborne-Johnston and coworkers presented a scoring system to stratify risk of stroke following transient ischaemic attack. Chalela and colleagues demonstrated that magnetic resonance imaging is superior to computed tomography in detecting acute ischaemic stroke and that fears of missing intracranial haemorrhage are unfounded. The SITS-MOST (Safe Implementation of Thrombolysis in Stroke – Monitoring Study) group reported positive experience of translating acute stroke thrombolysis trials into routine clinical practice in Europe, and the PROSIT (Project on Stroke Services in Italy) group studied acute effects of admission to a dedicated stroke unit. The message from all of these reports is that evidence-based, successful management of acute stroke is possible, and that investment in health infrastructure and changing mind sets of health practitioners to improve stroke care will deliver benefits.
Literature
1.
go back to reference Johnston SC, Rothwell PF, Nguyen-huynh MN, Giles MF, Elkins JS, Bernstein AL, Sidney S: Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007, 369: 283-292. 10.1016/S0140-6736(07)60150-0CrossRefPubMed Johnston SC, Rothwell PF, Nguyen-huynh MN, Giles MF, Elkins JS, Bernstein AL, Sidney S: Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007, 369: 283-292. 10.1016/S0140-6736(07)60150-0CrossRefPubMed
2.
go back to reference Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, Hill MD, Patronas N, Latour L, Warach S: Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 2007, 369: 293-298. 10.1016/S0140-6736(07)60151-2PubMedCentralCrossRefPubMed Chalela JA, Kidwell CS, Nentwich LM, Luby M, Butman JA, Demchuk AM, Hill MD, Patronas N, Latour L, Warach S: Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 2007, 369: 293-298. 10.1016/S0140-6736(07)60151-2PubMedCentralCrossRefPubMed
3.
go back to reference Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, for the SITS-MOST investigators, et al.: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke – Monitoring Study (SITS-MOST): an observational study. Lancet 2007, 369: 275-282. 10.1016/S0140-6736(07)60149-4CrossRefPubMed Wahlgren N, Ahmed N, Davalos A, Ford GA, Grond M, Hacke W, Hennerici MG, Kaste M, Kuelkens S, Larrue V, for the SITS-MOST investigators, et al.: Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke – Monitoring Study (SITS-MOST): an observational study. Lancet 2007, 369: 275-282. 10.1016/S0140-6736(07)60149-4CrossRefPubMed
4.
go back to reference Candelise L, Gattinoni M, Bersano A, Micieli G, Sterzi R, Morabito A, on behalf of the PROSIT Study Group: Stroke-unit care for acute stroke patients: an observational follow-up study. Lancet 2007, 369: 299-305. 10.1016/S0140-6736(07)60152-4CrossRefPubMed Candelise L, Gattinoni M, Bersano A, Micieli G, Sterzi R, Morabito A, on behalf of the PROSIT Study Group: Stroke-unit care for acute stroke patients: an observational follow-up study. Lancet 2007, 369: 299-305. 10.1016/S0140-6736(07)60152-4CrossRefPubMed
5.
go back to reference Goldstein LB, Simel DL: Is this patient having a stroke? JAMA 2005, 293: 2391-2402. 10.1001/jama.293.19.2391CrossRefPubMed Goldstein LB, Simel DL: Is this patient having a stroke? JAMA 2005, 293: 2391-2402. 10.1001/jama.293.19.2391CrossRefPubMed
6.
go back to reference North American Symptomatic Carotid Endarterectomy Trial Collaborators: Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991, 325: 445-453.CrossRef North American Symptomatic Carotid Endarterectomy Trial Collaborators: Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991, 325: 445-453.CrossRef
7.
go back to reference International Stroke Trial Collaborative Group: The international stroke trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997, 349: 1569-1581. 10.1016/S0140-6736(97)04011-7CrossRef International Stroke Trial Collaborative Group: The international stroke trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 1997, 349: 1569-1581. 10.1016/S0140-6736(97)04011-7CrossRef
8.
go back to reference Royal College of Physicians: National Clinical Guidelines for Stroke. London, UK: Royal College of Physicians; 2004. Royal College of Physicians: National Clinical Guidelines for Stroke. London, UK: Royal College of Physicians; 2004.
9.
go back to reference Menon V, Harrington RA, Hochman JS, Cannon CP, Goodman SD, Wilcox RG, Schunemann HJ, Ohman EM: Thrombolysis and adjunctive therapy in acute myocardial infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004,126(3 Suppl):549S-575S. 10.1378/chest.126.3_suppl.549SCrossRefPubMed Menon V, Harrington RA, Hochman JS, Cannon CP, Goodman SD, Wilcox RG, Schunemann HJ, Ohman EM: Thrombolysis and adjunctive therapy in acute myocardial infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004,126(3 Suppl):549S-575S. 10.1378/chest.126.3_suppl.549SCrossRefPubMed
10.
go back to reference The National Institute of Neurological Disorders and Stroke rt-PA study group: Tissue plasminogen activator for acute stroke. N Engl J Med 1995, 333: 1581-1587. 10.1056/NEJM199512143332401CrossRef The National Institute of Neurological Disorders and Stroke rt-PA study group: Tissue plasminogen activator for acute stroke. N Engl J Med 1995, 333: 1581-1587. 10.1056/NEJM199512143332401CrossRef
11.
go back to reference Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broder-ick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, et al.: Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004, 363: 768-744. 10.1016/S0140-6736(04)15692-4CrossRefPubMed Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broder-ick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, et al.: Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004, 363: 768-744. 10.1016/S0140-6736(04)15692-4CrossRefPubMed
12.
go back to reference Stroke Unit Trialist' Collaboration: Organised inpatient (stroke unit) care for stroke (Cochrane Review). Cochrane Database Syst Rev 2002, 1: CD000197. Stroke Unit Trialist' Collaboration: Organised inpatient (stroke unit) care for stroke (Cochrane Review). Cochrane Database Syst Rev 2002, 1: CD000197.
Metadata
Title
Acute stroke: we have the treatments and we have the evidence – we need to use them
Authors
Terence J Quinn
Jesse Dawson
Kennedy R Lees
Publication date
01-04-2007
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2007
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5731

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