Skip to main content
Top
Published in: Critical Care 2/2007

Open Access 01-04-2007 | Research

Optimizing intensive care capacity using individual length-of-stay prediction models

Authors: Mark Van Houdenhoven, Duy-Tien Nguyen, Marinus J Eijkemans, Ewout W Steyerberg, Hugo W Tilanus, Diederik Gommers, Gerhard Wullink, Jan Bakker, Geert Kazemier

Published in: Critical Care | Issue 2/2007

Login to get access

Abstract

Introduction

Effective planning of elective surgical procedures requiring postoperative intensive care is important in preventing cancellations and empty intensive care unit (ICU) beds. To improve planning, we constructed, validated and tested three models designed to predict length of stay (LOS) in the ICU in individual patients.

Methods

Retrospective data were collected from 518 consecutive patients who underwent oesophagectomy with reconstruction for carcinoma between January 1997 and April 2005. Three multivariable linear regression models for LOS, namely preoperative, postoperative and intra-ICU, were constructed using these data. Internal validation was assessed using bootstrap sampling in order to obtain validated estimates of the explained variance (r2). To determine the potential gain of the best performing model in day-to-day clinical practice, prospective data from a second cohort of 65 consecutive patients undergoing oesophagectomy between May 2005 and April 2006 were used in the model, and the predictive performance of the model was compared with prediction based on mean LOS.

Results

The intra-ICU model had an r2 of 45% after internal validation. Important prognostic variables for LOS included greater patient age, comorbidity, type of surgical approach, intraoperative respiratory minute volume and complications occurring within 72 hours in the ICU. The potential gain of the best model in day-to-day clinical practice was determined relative to mean LOS. Use of the model reduced the deficit number (underestimation) of ICU days by 65 and increased the excess number (overestimation) of ICU days by 23 for the cohort of 65 patients. A conservative analysis conducted in the second, prospective cohort of patients revealed that 7% more oesophagectomies could have been accommodated, and 15% of cancelled procedures could have been prevented.

Conclusion

Patient characteristics can be used to create models that will help in predicting LOS in the ICU. This will result in more efficient use of ICU beds and fewer cancellations.
Appendix
Available only for authorised users
Literature
1.
go back to reference Duke GJ: Metropolitan audit of appropriate referrals refused admission to intensive care. Anaesth Intensive Care 2004, 32: 702-706.PubMed Duke GJ: Metropolitan audit of appropriate referrals refused admission to intensive care. Anaesth Intensive Care 2004, 32: 702-706.PubMed
2.
go back to reference Garrouste-Org , Montuclard L, Timsit JF, Reignier J, Desmettre T, Karoubi P: Predictors of intensive care unit refusal in French intensive care units: a multiple-center study. Crit Care Med 2005, 33: 750-755. 10.1097/01.CCM.0000157752.26180.F1CrossRef Garrouste-Org , Montuclard L, Timsit JF, Reignier J, Desmettre T, Karoubi P: Predictors of intensive care unit refusal in French intensive care units: a multiple-center study. Crit Care Med 2005, 33: 750-755. 10.1097/01.CCM.0000157752.26180.F1CrossRef
3.
go back to reference Levin PD, Worner TM, Sviri S, Goodman SV, Weiss YG, Einav S, Weissman C, Sprung CL: Intensive care outflow limitation-frequency, etiology, and impact. J Crit Care 2003, 18: 206-211. 10.1016/j.jcrc.2003.10.003CrossRefPubMed Levin PD, Worner TM, Sviri S, Goodman SV, Weiss YG, Einav S, Weissman C, Sprung CL: Intensive care outflow limitation-frequency, etiology, and impact. J Crit Care 2003, 18: 206-211. 10.1016/j.jcrc.2003.10.003CrossRefPubMed
4.
go back to reference Bakker J, Damen J, van Zanten AR, Hubben JH: Admission and discharge criteria for intensive care departments. Ned Tijdschr Geneeskd 2003, 147: 110-115.PubMed Bakker J, Damen J, van Zanten AR, Hubben JH: Admission and discharge criteria for intensive care departments. Ned Tijdschr Geneeskd 2003, 147: 110-115.PubMed
5.
go back to reference American Society of Anesthesiologists: New classification of physical status. Anesthesiology 1963, 24: 111. American Society of Anesthesiologists: New classification of physical status. Anesthesiology 1963, 24: 111.
6.
go back to reference Rempe-Sorm V: Management of postoperative complications. In Barrett's Esophagus. Edited by: Tilanus HW, Attwood SE. Dordrecht: Kluwer Academic Publishers; 2001:357-366.CrossRef Rempe-Sorm V: Management of postoperative complications. In Barrett's Esophagus. Edited by: Tilanus HW, Attwood SE. Dordrecht: Kluwer Academic Publishers; 2001:357-366.CrossRef
7.
go back to reference Sobin LH, Wittekind CH, (editors): TNM Classification of Malignant Tumours (UICC). New Jersey: John Wiley & Sons; 2002:60-65. Sobin LH, Wittekind CH, (editors): TNM Classification of Malignant Tumours (UICC). New Jersey: John Wiley & Sons; 2002:60-65.
8.
go back to reference Avendano CE, Flume PA, Silvestri GA, King LB, Reed CE: Pulmonary complications after esophagectomy. Ann Thorac Surg 2002, 73: 922-926. 10.1016/S0003-4975(01)03584-6CrossRefPubMed Avendano CE, Flume PA, Silvestri GA, King LB, Reed CE: Pulmonary complications after esophagectomy. Ann Thorac Surg 2002, 73: 922-926. 10.1016/S0003-4975(01)03584-6CrossRefPubMed
9.
go back to reference Bartels H, Stein HJ, Siewert JR: Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 1998, 85: 840-844. 10.1046/j.1365-2168.1998.00663.xCrossRefPubMed Bartels H, Stein HJ, Siewert JR: Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 1998, 85: 840-844. 10.1046/j.1365-2168.1998.00663.xCrossRefPubMed
10.
go back to reference Ferguson MK, Martin TR, Reeder LB, Olak J: Mortality after esophagectomy: risk factor analysis. World J Surg 1997, 21: 599-603. 10.1007/s002689900279CrossRefPubMed Ferguson MK, Martin TR, Reeder LB, Olak J: Mortality after esophagectomy: risk factor analysis. World J Surg 1997, 21: 599-603. 10.1007/s002689900279CrossRefPubMed
11.
go back to reference Law S, Wong KH, Kwok KF, Chu KM, Wong J: Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer. Ann Surg 2004, 240: 791-800. 10.1097/01.sla.0000143123.24556.1cPubMedCentralCrossRefPubMed Law S, Wong KH, Kwok KF, Chu KM, Wong J: Predictive factors for postoperative pulmonary complications and mortality after esophagectomy for cancer. Ann Surg 2004, 240: 791-800. 10.1097/01.sla.0000143123.24556.1cPubMedCentralCrossRefPubMed
12.
go back to reference Tsutsui S, Moriguchi S, Morita M, Kuwano H, Matsuda H, Mori M, et al.: Multivariate analysis of postoperative complications after esophageal resection. Ann Thorac Surg 1992, 53: 1052-1056.CrossRefPubMed Tsutsui S, Moriguchi S, Morita M, Kuwano H, Matsuda H, Mori M, et al.: Multivariate analysis of postoperative complications after esophageal resection. Ann Thorac Surg 1992, 53: 1052-1056.CrossRefPubMed
13.
go back to reference Spiegelhalter DJ: Probabilistic prediction in patient management and clinical trials. Stat Med 1986, 5: 421-433.CrossRefPubMed Spiegelhalter DJ: Probabilistic prediction in patient management and clinical trials. Stat Med 1986, 5: 421-433.CrossRefPubMed
14.
go back to reference Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD: Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. Stat Med 2000, 19: 1059-1079. 10.1002/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0CrossRefPubMed Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD: Prognostic modelling with logistic regression analysis: a comparison of selection and estimation methods in small data sets. Stat Med 2000, 19: 1059-1079. 10.1002/(SICI)1097-0258(20000430)19:8<1059::AID-SIM412>3.0.CO;2-0CrossRefPubMed
15.
go back to reference Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD: Prognostic modeling with logistic regression analysis: in search of a sensible strategy in small data sets. Med Decis Making 2001, 21: 45-56.CrossRefPubMed Steyerberg EW, Eijkemans MJ, Harrell FE Jr, Habbema JD: Prognostic modeling with logistic regression analysis: in search of a sensible strategy in small data sets. Med Decis Making 2001, 21: 45-56.CrossRefPubMed
16.
go back to reference Rubin DB, Schenker N: Multiple imputation in health-care databases: an overview and some applications. Stat Med 1991, 10: 585-598.CrossRefPubMed Rubin DB, Schenker N: Multiple imputation in health-care databases: an overview and some applications. Stat Med 1991, 10: 585-598.CrossRefPubMed
17.
go back to reference Strum DP, May JH, Vargas LG: Modeling the uncertainty of surgical procedure times: comparison of log-normal and normal models. Anesthesiology 2000, 92: 1160-1167. 10.1097/00000542-200004000-00035CrossRefPubMed Strum DP, May JH, Vargas LG: Modeling the uncertainty of surgical procedure times: comparison of log-normal and normal models. Anesthesiology 2000, 92: 1160-1167. 10.1097/00000542-200004000-00035CrossRefPubMed
18.
go back to reference Duan N: Smearing estimate: a nonparametric retransformation method. J Am Stat Assoc 1983, 383: 605-610. 10.2307/2288126CrossRef Duan N: Smearing estimate: a nonparametric retransformation method. J Am Stat Assoc 1983, 383: 605-610. 10.2307/2288126CrossRef
19.
go back to reference Efron B, Tibshirani RJ: An Introduction to the Bootstrap. New York, NY: Chapman and Hall; 1993.CrossRef Efron B, Tibshirani RJ: An Introduction to the Bootstrap. New York, NY: Chapman and Hall; 1993.CrossRef
20.
go back to reference Steyerberg EW, Harrell FE, Borsboom GJJM, Eijkemans MJC, Vergouwe Y, Habbema JDF: Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 2001, 54: 774-781. 10.1016/S0895-4356(01)00341-9CrossRefPubMed Steyerberg EW, Harrell FE, Borsboom GJJM, Eijkemans MJC, Vergouwe Y, Habbema JDF: Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 2001, 54: 774-781. 10.1016/S0895-4356(01)00341-9CrossRefPubMed
21.
go back to reference Harrell FE, Lee KL, Mark DB: Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996, 15: 361-387.CrossRefPubMed Harrell FE, Lee KL, Mark DB: Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996, 15: 361-387.CrossRefPubMed
22.
go back to reference van de Pol MA, van Houdenhoven M, Hans EW, Boersma E, Bax JJ, Feringa HH, Schouten O, van Sambeek MR, Poldermans D: Influence of cardiac risk factors and medication on length of hospitalization in patients undergoing major vascular surgery. Am J Cardiol 2006, 97: 1423-1426. 10.1016/j.amjcard.2005.12.032CrossRefPubMed van de Pol MA, van Houdenhoven M, Hans EW, Boersma E, Bax JJ, Feringa HH, Schouten O, van Sambeek MR, Poldermans D: Influence of cardiac risk factors and medication on length of hospitalization in patients undergoing major vascular surgery. Am J Cardiol 2006, 97: 1423-1426. 10.1016/j.amjcard.2005.12.032CrossRefPubMed
23.
go back to reference Van den BG, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al.: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521CrossRef Van den BG, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al.: Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354: 449-461. 10.1056/NEJMoa052521CrossRef
24.
go back to reference Ammori BJ, Larvin M, McMahon MJ: Elective laparoscopic cholecystectomy: preoperative prediction of duration of surgery. Surg Endosc 2001, 15: 297-300. 10.1007/s004640000247CrossRefPubMed Ammori BJ, Larvin M, McMahon MJ: Elective laparoscopic cholecystectomy: preoperative prediction of duration of surgery. Surg Endosc 2001, 15: 297-300. 10.1007/s004640000247CrossRefPubMed
25.
go back to reference Collins TC, Daley J, Henderson WH, Khuri SF: Risk factors for prolonged length of stay after major elective surgery. Ann Surg 1999, 230: 251-259. 10.1097/00000658-199908000-00016PubMedCentralCrossRefPubMed Collins TC, Daley J, Henderson WH, Khuri SF: Risk factors for prolonged length of stay after major elective surgery. Ann Surg 1999, 230: 251-259. 10.1097/00000658-199908000-00016PubMedCentralCrossRefPubMed
26.
go back to reference Janssen DP, Noyez L, Wouters C, Brouwer RM: Preoperative prediction of prolonged stay in the intensive care unit for coronary bypass surgery. Eur J Cardiothorac Surg 2004, 25: 203-207. 10.1016/j.ejcts.2003.11.005CrossRefPubMed Janssen DP, Noyez L, Wouters C, Brouwer RM: Preoperative prediction of prolonged stay in the intensive care unit for coronary bypass surgery. Eur J Cardiothorac Surg 2004, 25: 203-207. 10.1016/j.ejcts.2003.11.005CrossRefPubMed
27.
go back to reference McMeekin DS, Gazzaniga C, Berman M, DiSaia P, Manetta A: Retrospective review of gynecologic oncology patients with therapy-induced neutropenic fever. Gynecol Oncol 1996, 62: 247-253. 10.1006/gyno.1996.0223CrossRefPubMed McMeekin DS, Gazzaniga C, Berman M, DiSaia P, Manetta A: Retrospective review of gynecologic oncology patients with therapy-induced neutropenic fever. Gynecol Oncol 1996, 62: 247-253. 10.1006/gyno.1996.0223CrossRefPubMed
28.
go back to reference Rosenfeld R, Smith JM, Woods SE, Engel AM: Predictors and outcomes of extended intensive care unit length of stay in patients undergoing coronary artery bypass graft surgery. J Card Surg 2006, 21: 146-150. 10.1111/j.1540-8191.2006.00196.xCrossRefPubMed Rosenfeld R, Smith JM, Woods SE, Engel AM: Predictors and outcomes of extended intensive care unit length of stay in patients undergoing coronary artery bypass graft surgery. J Card Surg 2006, 21: 146-150. 10.1111/j.1540-8191.2006.00196.xCrossRefPubMed
29.
go back to reference Stoica SC, Sharples LD, Ahmed I, Roques F, Large SR, Nashef SA: Preoperative risk prediction and intraoperative events in cardiac surgery. Eur J Cardiothorac Surg 2002, 21: 41-46. 10.1016/S1010-7940(01)01077-6CrossRefPubMed Stoica SC, Sharples LD, Ahmed I, Roques F, Large SR, Nashef SA: Preoperative risk prediction and intraoperative events in cardiac surgery. Eur J Cardiothorac Surg 2002, 21: 41-46. 10.1016/S1010-7940(01)01077-6CrossRefPubMed
30.
go back to reference Tu JV, Mazer CD, Levinton C, Armstrong PW, Naylor CD: A predictive index for length of stay in the intensive care unit following cardiac surgery. CMAJ 1994, 151: 177-185.PubMedCentralPubMed Tu JV, Mazer CD, Levinton C, Armstrong PW, Naylor CD: A predictive index for length of stay in the intensive care unit following cardiac surgery. CMAJ 1994, 151: 177-185.PubMedCentralPubMed
31.
go back to reference Aronow HD, Peyser PA, Eagle KA, Bates ER, Werns SW, Russman PL, Crum MA, Harris K, Moscucci M: Predictors of length of stay after coronary stenting. Am Heart J 2001, 142: 799-805. 10.1067/mhj.2001.119371CrossRefPubMed Aronow HD, Peyser PA, Eagle KA, Bates ER, Werns SW, Russman PL, Crum MA, Harris K, Moscucci M: Predictors of length of stay after coronary stenting. Am Heart J 2001, 142: 799-805. 10.1067/mhj.2001.119371CrossRefPubMed
32.
go back to reference Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL: intensive care unit length of stay: benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med 2006, 34: 2517-2529. 10.1097/01.CCM.0000240233.01711.D9CrossRefPubMed Zimmerman JE, Kramer AA, McNair DS, Malila FM, Shaffer VL: intensive care unit length of stay: benchmarking based on Acute Physiology and Chronic Health Evaluation (APACHE) IV. Crit Care Med 2006, 34: 2517-2529. 10.1097/01.CCM.0000240233.01711.D9CrossRefPubMed
33.
go back to reference Lerut T, Coosemans W, Decker G, De Leyn P, Moons J: Surgical techniques. J Surg Oncol 2005, 92: 218-229. 10.1002/jso.20363CrossRefPubMed Lerut T, Coosemans W, Decker G, De Leyn P, Moons J: Surgical techniques. J Surg Oncol 2005, 92: 218-229. 10.1002/jso.20363CrossRefPubMed
34.
go back to reference Chandrashekar MV, Irving M, Wayman J, Raimes SA, Linsley A: Immediate extubation and epidural analgesia allow safe management in a high-dependency unit after two-stage oesophagectomy. Results of eight years of experience in a specialized upper gastrointestinal unit in a district general hospital. Br J Anaesth 2003, 90: 474-479. 10.1093/bja/aeg091CrossRefPubMed Chandrashekar MV, Irving M, Wayman J, Raimes SA, Linsley A: Immediate extubation and epidural analgesia allow safe management in a high-dependency unit after two-stage oesophagectomy. Results of eight years of experience in a specialized upper gastrointestinal unit in a district general hospital. Br J Anaesth 2003, 90: 474-479. 10.1093/bja/aeg091CrossRefPubMed
35.
go back to reference Kuo EY, Chang Y, Wright CD: Impact of hospital volume on clinical and economic outcomes for esophagectomy. Ann Thorac Surg 2001, 72: 1118-1124. 10.1016/S0003-4975(01)02962-9CrossRefPubMed Kuo EY, Chang Y, Wright CD: Impact of hospital volume on clinical and economic outcomes for esophagectomy. Ann Thorac Surg 2001, 72: 1118-1124. 10.1016/S0003-4975(01)02962-9CrossRefPubMed
Metadata
Title
Optimizing intensive care capacity using individual length-of-stay prediction models
Authors
Mark Van Houdenhoven
Duy-Tien Nguyen
Marinus J Eijkemans
Ewout W Steyerberg
Hugo W Tilanus
Diederik Gommers
Gerhard Wullink
Jan Bakker
Geert Kazemier
Publication date
01-04-2007
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2007
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5730

Other articles of this Issue 2/2007

Critical Care 2/2007 Go to the issue