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Critical Care
Published in: Critical Care 4/2006

01-08-2006 | Letter

Timing of drotrecogin alfa (activated) treatment in severe sepsis

Authors: Goda Choi, Anne-Cornélie JM de Pont, Marcus J Schultz

Published in: Critical Care | Issue 4/2006

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Excerpt

The effect of the timing of drotrecogin alfa (activated) (DrotAA) treatment on the outcome of severe sepsis was recently evaluated, using the integrated clinical trial database INDEPTH. The evaluation demonstrated an association between earlier treatment (i.e. treatment within 24 hours of the appearance of first organ dysfunction) and lower patient mortality [1]. …
Literature
1.
Vincent JL, O'Brien J Jr, Wheeler A, Wittebole X, Garg R, Trzaskoma BL, Sundin DP: Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis. Crit Care 2006, 10: R74. 10.1186/cc4909PubMedCentralCrossRefPubMed
2.
Girbes ARJ, Bakker J, van Deuren M, van Hout BA, van Leeuwen SJ, Levi M, Schultz MJ, van Zanten ARH: Toepassing drotrecogin alpha, geactiveerd proteine C (aPC) bij de behandeling van ernstige sepsis. Neth J Crit Care 2005, 9: 165-166.
3.
Laterre PF, Garber G, Levy H, Wunderink R, Kinasewitz GT, Sollet JP, Maki DG, Bates B, Yan SC, Dhainaut JF: Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study. Crit Care Med 2005, 33: 952-961. 10.1097/01.CCM.0000162381.24074.D7CrossRefPubMed
Metadata
Title
Timing of drotrecogin alfa (activated) treatment in severe sepsis
Authors
Goda Choi
Anne-Cornélie JM de Pont
Marcus J Schultz
Publication date
01-08-2006
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2006
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5010

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