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Critical Care
Published in: Critical Care 5/2005

01-10-2005 | Review

Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis

Author: Sébastien Gibot

Published in: Critical Care | Issue 5/2005

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Abstract

Triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule that is involved in monocytic activation and in the inflammatory response. It belongs to a family related to the natural killer cell receptors and is expressed on neutrophils, mature monocytes and macrophages. The inflammatory response mediated by Toll-like receptor-2 and -4 stimulation is amplified by the engagement of TREM-1. The expression of membrane-bound TREM-1 is greatly increased on monocytes during sepsis. Moreover, infection induces the release of a soluble form of this receptor, which can be measured in biological fluid and may be useful as a diagnostic tool. Modulation of the TREM-1 signalling pathway by the use of small synthetic peptides confers interesting survival advantages during experimental septic shock in mice, even when this teatment is administered late after the onset of sepsis.
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Metadata
Title
Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis
Author
Sébastien Gibot
Publication date
01-10-2005
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3732

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