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01-04-2005 | Brief Report

Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock

Authors: Sébastien Gibot, Pol-Edern Le Renard, Pierre-Edouard Bollaert, Marie-Nathalie Kolopp-Sarda, Marie-Christine Béné, Gilbert C. Faure, Bruno Lévy

Published in: Intensive Care Medicine | Issue 4/2005

Abstract

Objective

To analyze the pattern of cell-surface expression of the triggering receptor expressed on myeloid cells (TREM) 1 during septic shock.

Design and setting

Prospective clinical study in an adult 16-bed medical ICU.

Patients and methods

25 septic shock patients, 15 patients with shock of noninfectious origin and 7 healthy volunteers. Arterial blood was drawn within 12 h of admission and subjected to flow cytometry analysis after staining with anti-TREM-1 and anti-CD14 antibodies. Repeated sampling was performed on days 2, 3, 5, 7, and 14 in septic shock patients.

Results

Monocytic TREM-1 expression was significantly higher in septic shock patients (mean fluorescence intensity 2.3±0.2) than in nonseptic patients (1.0±0.1), and healthy volunteers (1.0±0.1). There was no difference in monocytic TREM-1 expression between nonseptic patients and healthy volunteers or between any of the three groups with respect to TREM-1 expression on neutrophils. The time course of TREM-1 expression on monocytes diverged significantly by day 3 between survivors and ns.

Conclusions

The specificity of TREM-1 regulation by infection is highlighted. Moreover, surface TREM-1 expression on monocytes may prove useful in allowing the follow-up of septic patients during the course of the disease

Available only for authorised users

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Title: Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock
Authors: Sébastien Gibot
Pol-Edern Le Renard
Pierre-Edouard Bollaert
Marie-Nathalie Kolopp-Sarda
Marie-Christine Béné
Gilbert C. Faure
Bruno Lévy
Publication date: 01-04-2005
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 4/2005
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-005-2572-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock

Abstract

Objective

Design and setting

Patients and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Patients and methods

Results

Conclusions

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