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Critical Care
Published in: Critical Care 2/2005

01-04-2004 | Review

Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians

Authors: Ana L Huerta-Alardín, Joseph Varon, Paul E Marik

Published in: Critical Care | Issue 2/2005

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Abstract

Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase, electrolyte imbalances, acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies, electrolyte abnormalities, infectious causes, drugs, toxins and endocrinopathies. Weakness, myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration.
Appendix
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Literature
1.
Farmer J: Rhabdomyolysis. In In Critical Care. 2nd edition. Edited by: Civetta J, Taylor R, Kirby R. Philadephia, PA: Lippincott; 1997:1785-1791.
2.
Warren J, Blumberg P, Thompson P: Rhabdomyolysis: a review. Muscle Nerve 2002, 25: 332-347. 10.1002/mus.10053PubMed
3.
Book of Numbers: The Bible. The New English Bible, 1970 Joint Comitee on the New Translation of the Bible. Volume 11. New York: Cambridge University Press; 31-35.
4.
Rizzi D, Basile C, Di Maggio A: Clinical spectrum of accidental hemlock poisoning: neurologic manifestations, rhabdomyolysis and acute tubular necrosis. Nephrol Dial Transplant 1991, 6: 939-943.PubMed
5.
6.
Smith L, Post R, Teschan P, Abernathy R, Davis J, Gray D, Howard J, Johnson K, Klopp E, Mundy R, et al.: Postraumatic renal insufficiency in military casualties. II Management, use of an artificial kidney, prognosis. Am J Med 1955, 18: 187-198. 10.1016/0002-9343(55)90234-5PubMed
7.
Stone W, Knepshield J: Post traumatic acute renal insufficiency in Vietnam. Clin Nephrol 1974, 2: 189-190.
8.
Bywaters EGI, Stead BJK: The production of renal failure following injection of solutions containing myohaemoglobin. Q J Exp Physiol 1944, 33: 53-70.
9.
Korein J, Coddon D, Mowrey F: The clinical spectrum of paroxysmal paralytic myoglobinuria. Neurology 1959, 9: 767-785.PubMed
10.
Rowland L, Penn A: Myoglobinuria. Med Clin North Am 1972, 56: 1233-1256.PubMed
11.
Grossman R, Hamilton R, Morse B, Penn A, Goldberg M: Nontraumatic rhabdomyolysis and acute renal failure. N Engl J Med 1974, 291: 807-811.PubMed
12.
Ward M: Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med 1988, 148: 1553-1557. 10.1001/archinte.148.7.1553PubMed
13.
Brivet F, Keinknecht D, Loirat P, Landais P: Acute renal failure in intensive care units – causes, outcomes, and prognostic factors of hospital mortality: a prospective multicenter study. Crit Care Med 1996, 24: 192-198. 10.1097/00003246-199602000-00003PubMed
14.
15.
Splendiani G, Mazzarella V, Cipriani S, Zazzaro D, Casciani C: Dialytic treatment of rhabdomyolysis-induced acute renal failure: our experience. Ren Fail 2001, 23: 183-191. 10.1081/JDI-100103490PubMed
16.
Sever M, Erek E, Vanholder R, Akoglu E, Yavaz M, Ergin H, Tekce M, Korular D, Tulbek M, Keven K, et al.: The Marmara earthquake: epidemiological analysis of the victims with nephrological problems. Kidney Int 2001, 60: 1114-1123. 10.1046/j.1523-1755.2001.0600031114.xPubMed
17.
Gabow P, Kaehny W, Kelleher S: The spectrum of rhabdomyolysis. Medicine 1982, 62: 141-152.
18.
Vanholder R, Sever M, Erek E, Lemeire N: Acute renal failure related to the crush syndrome: towards an era or seismonephrology? Nephrol Dial Transplant 2000, 15: 1517-1521. 10.1093/ndt/15.10.1517PubMed
19.
Kantarci G, Vanholder R, Tuglular S, Akin H, Koc M, Ozeenr C, Akogu E: Acute renal failure due to crush syndrome during Marmara earthquake. Am J Kidney Dis 2002, 40: 682-689. 10.1053/ajkd.2002.35673PubMed
20.
21.
Goldfarb D, Chung S: The absence of rhabdomyolysis induced renal failure following the world trade center collapse [letter]. Am J Med 2002, 113: 260. 10.1016/S0002-9343(02)01188-9PubMed
22.
Odeh M: The role of reperfusion-induced injury in the pathogenesis of the crush syndrome. N Engl J Med 1991, 324: 1417-1422.PubMed
23.
Defraigne JO, Pincmail J: Local and systemic consequences of severe ischemia and reperfusion of the skeletal muscle: physiopathology and prevention. Acta Chir Belg 1998, 98: 176-186.PubMed
24.
Adiseshiah M, Round J, Jones D: Reperfusion injury in skeletal muscle: a prospective study in patient with acute limb ischemia and claudication treated by revascularization. Br J Surg 1992, 79: 1026-1029.PubMed
25.
Biswas S, Gnanasekaran I, Ivatury R, Simon R, Patel A: Exaggerated lithotomy position-related rhabdomyolysis. Am Surg 1997, 63: 361-364.PubMed
26.
Schiff H, MacSearraigh E, Kallmeyer J: Myoglobinuria, rhabdomyolysis and marathon running. Q J Med 1978, 47: 463-472.PubMed
27.
Schafer M, Less H, Steiner I, Breezier M: Hazard of sauna after strenuous exercise. Ann Intern Med 1994, 120: 441-442.
28.
Visweswaran P, Guntupalli J: Rhabdomyolysis. Crit Care Clin 1999, 15: 415-412.PubMed
29.
Poels P, Gabreels F: Rhabdomyolysis: a review of literature. Clin Neurol Neurosurg 1995, 95: 175-192. 10.1016/0303-8467(93)90122-W
30.
Rosen C, Adler J, Rabban J, Sethi R, Arkoff L, Blair J, Sheridan R: Early predictors of myoglobinuria and acute renal failure following electrical injury. J Emerg Med 1999, 17: 783-789. 10.1016/S0736-4679(99)00084-0PubMed
31.
Slater M, Mullins R: Rhabdomyolysis and myoglobinuric acute renal failure in trauma and surgical patients: a review. J Am Coll Surg 1998, 186: 693-716. 10.1016/S1072-7515(98)00089-1PubMed
32.
Frank D, Fisher J: Complications of electrical injury. In In Complications in Surgery and Trauma. Edited by: Greenfield LJ. Philadelphia, PA: Lippincott-Raven; 1990.
33.
Brumback R, Feeback D, Leech R: Rhabdomyolysis following electrical injury. Semin Neurol 1995, 15: 329-334.PubMed
34.
Denborough M: Malignant hyperthermia. Lancet 1998, 352: 1131-1136. 10.1016/S0140-6736(98)03078-5PubMed
35.
Ali S, Taguchi A, Rosenberg H: Malignant hyperthermia. Best Pract Resp Clin Anaesthesiol 2003, 4: 519-533. 10.1016/j.bpa.2003.09.012
36.
Abraham B, Cahana A, Krivosic-Horber R, Perel A: Malignant hyperthermia susceptibility: anaesthetic implications and risk stratification. Q J Med 1997, 90: 13-18.
37.
Simon H: Hyperthermia. N Eng J Med 1993, 329: 483-487. 10.1056/NEJM199308123290708
38.
Schneider S: Neuroleptic malignant syndrome: controversies in treatment. Am J Emerg Med 1991, 9: 360-362. 10.1016/0735-6757(91)90058-RPubMed
39.
Guze B, Baxter L: Neuroleptic malignant syndrome. N Engl J Med 1985, 313: 163-166.PubMed
40.
Mann SC, Caroff SN, Fricchione G, Campbell EC: Central dopamine hypoactivity and the pathogenesis of the neuroleptic malignant syndrome. Psychiatr Annals 2000, 30: 363-374.
41.
Gibb W, Griffith D: Levodopa withdrawal syndrome identical to neuroleptic malignant syndrome. Postgrad Med J 1986, 62: 59-60.PubMedCentralPubMed
42.
Sato Y, Asoh T, Metoki N, Satoh K: Efficacy of methylprednisolone pulse therapy on neuroleptic malignant syndrome in Parkinson's disease. J Neurol Neurosurg Psychiatry 2003, 74: 574-576. 10.1136/jnnp.74.5.574PubMedCentralPubMed
43.
Varon J, Jacobs M: Treating the progressive stages of Parkinson's disease. Postgrad Med 1991, 90: 63-71.PubMed
44.
Bross M, Nash B, Carlton F: Heat emergencies. Am Fam Physician 1994, 50: 389-396.PubMed
45.
Tek D, Olshaker J: Heat illness. Emerg Med Clin North Am 1992, 10: 299-310.PubMed
46.
Dematte J, O'Mara K, Buescher J, Whitney C, Forsythe S, McNamee T, Adiga R, Ndukwu I: Near fatal heat stroke during the 1995 heat wave in Chicago. Ann Intern Med 1998, 129: 173-181.PubMed
47.
Moghtader J, Brady W, Bonadio W: Exertional rhabdomyolysis in an adolescent athelete. Pediatr Emerg Care 1997, 13: 382-385.PubMed
48.
Varon J, Sadovnikoff N, Sternbach G: Hypothermia: saving patients from the big chill. Postgrad Med 1992, 92: 47-59.PubMed
49.
Varon J, Varon S, Fromm R, Sternbach G: Hypothermia – ABCs of diagnosis and treatment. Med Interam 1994, 13: 189-192.
50.
Vissing J, Haller R: The effect of oral sucrose on exercise tolerance in patients with McArdle's disease. N Engl J Med 2003, 349: 2503-2509. 10.1056/NEJMoa031836PubMed
51.
Brumback R, Feeback D, Leech R: Rhabdomyolysis in childhood. Pediatr Neurol 1992, 39: 821-858.
52.
Nakajima H, Hamaguchi T, Yamasaki T, Tarui S: Phosphofructokinase deficiency: recent advances in molecular biology. Muscle Nerve 1995, 3: S28-S34.PubMed
53.
Zager R: Rhabdomyolysis and myohemoglobinuric acute renal failure. Kidney Int 1996, 49: 314-326.PubMed
54.
Lofberg M, Jankala H, Paetau A, Harkonen M, Somer H: Metabolic causes of recurrent rhabdomyolysis. Acta Neurol Scand 1998, 98: 268-275.PubMed
55.
Kakulas B: Experimental myopathies. In In Disorders of Voluntary Muscle. Edited by: Walton SJ. New York: Churchill Livingstone; 1981:393-400.
56.
Haskins N: Rhabdomyolysis and acute renal failure in intensive care. Nurs Crit Care 1998, 3: 283-238.PubMed
57.
Knochel J: Mechanisms of rhabdomyolysis. Curr Opin Rheumatol 1993, 5: 725-731.PubMed
58.
Jackson M, Jones D, Edwards R: Experimental skeletal muscle damage: the nature of the calcium activated degenerative processes. Eur J Clin Invest 1984, 14: 369-374.PubMed
59.
Rubin B, Liauw S, Tittley J, Romaschin A, Walker P: Prolonged adenine nucleotide resynthesis and reperfusion injury in post-ischemic skeletal muscle. Am J Physiol 1992, 262: H1538-H1547.PubMed
60.
Armstrong R, Warren G, Warren J: Mechanisms of exercise-induced muscle fiber injury. Sports Med 1991, 12: 184-207.PubMed
61.
Thompson PD, Clarkson P, Karas RH: Statin-associated myopathy. JAMA 2003, 289: 1681-1690. 10.1001/jama.289.13.1681PubMed
62.
Fuhrmans V: Bayer discloses higher death toll from Baycol. Wall Street J A10. 21 January 2002
63.
Ghirlanda G, Oradei A, Manto A, Lippa S, Uccioli L, Caputo S, Greco A, Littaru G: Evidence of plasma CoQ 10-lowering effect by HMG-CoA reductase inhibitors: a doble blind, placebo-controlled study. J Clin Pharmacol 1992, 33: 226-229.
64.
Staffa JA, Chang J, Green L: Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med 2002, 346: 539-540. 10.1056/NEJM200202143460721PubMed
65.
Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, Vladutiu G, England JD: Statin-associated myopathy with normal creatine kinase levels. Ann Intern Med 2002, 137: 581-585.PubMed
66.
Cassidy J, Bolton D, Haynes S, Smith J: Acute rhabdomyolysis after cardiac transplantation: a diagnostic conundrum. Paediatr Anaesth 2002, 12: 729-732. 10.1046/j.1460-9592.2002.00936.xPubMed
67.
Zager R: Studies of mechanisms and protective maneuvers in myoglobinuric acute renal injury. Lab Invest 1989, 60: 619-629.PubMed
68.
Knochel J, Bilbrey G, Fuller T, Carter N: The muscle cell in chronic alcoholism. The possible role of phosphate depletion in alcoholic cardiomyopathy. Ann NY Acad Sci 1975, 252: 274-286.PubMed
69.
Ferguson E, Blachley J, Carter N, Knochel J: Derangements of muscle composition, ion transport and oxygen consumption in chronically alcoholic dogs. Am J Physiol 1984, 246: F700-F709.PubMed
70.
Victor M: Toxic and nutritional myopathies. In In Myology. Volume II. Edited by: Engel AG, Banker BQ. New York: McGraw-Hill; 1986:1807-1842.
71.
Akmal M, Valdin J, McCarron M, Massry S: Rhabdomyolysis with and without acute renal failure in patients with phencyclidine intoxication. Am J Nephrol 1981, 1: 91-96.PubMed
72.
Welch RD, Todd K, Krause GS: Incidence of cocaine-associated rhabdomyolysis. Ann Emerg Med 1991, 20: 154-157.PubMed
73.
Singhal P, Rubin B, Peters A, Santiago A, Neugarten J: Rhabdomyolysis and acute renal failure associated with cocaine abuse. Clin Toxicol 1990, 28: 321-330.
74.
Koffler A, Friedler RM, Massry SG: Acute renal failure due to nontraumatic rhabdomyolysis. Ann Intern Med 1976, 85: 23-28.PubMed
75.
Timarchi H, Gonzalez J, Olivero J: Hyponatremia-associated rhabdomyolysis. Nephron 1999, 82: 274-277. 10.1159/000045413
76.
Cheney P: Early management and physiologic changes in crush syndrome. Crit Care Nurs Q 1994, 17: 62-73.PubMed
77.
Shintani S, Shliigai T, Tsukagoshi H: Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment. Eur Neurol 1991, 31: 396-398.PubMed
78.
Fukada Y, Oha S, Mizuno K, Hoshi K: Rhabdomyolysis secondary to hyperemesis gravidarum [case report]. Acta Obstet Gynecol Scand 1999, 78: 71.PubMed
79.
Pirovino M, Neff MS, Sharon E: Myoglobinuria and acute renal failure with acute polymyositis. NY State J Med 1979, 79: 764-767.
80.
Kagan L: Myoglobinemia in inflammatory myopathies. JAMA 1977, 237: 1448-1452. 10.1001/jama.237.14.1448PubMed
81.
Heidemann H, Kruezfelder E: Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. Klin Wochenschr 1983, 61: 303-305.PubMed
82.
Chang P, Lin C, Tsai M, Chien B, Cheng T, Lin C: Rhabdomyolysis associated with hperosmolar non-ketotic coma: a case report. Zhonghua Yi Xue Za Zhi 1988, 41: 309-310.PubMed
83.
Nishigara G, Higashi H, Matsuo S, Yasunaga C, Sakemi T, Nakamoto M: Acute renal failure due to hypokalemic rhabdomyolysis in Gitelman's syndrome. Clin Nephrol 1998, 50: 330-332.
84.
Alshanti M, Eledrisi M, Jones E: Rhabdomyolysis associated with hyperthyroidism [case report]. Am J Emerg Med 2001, 19: 317. 10.1053/ajem.2001.22483PubMed
85.
Singh U, Scheld M: Infectious etiologies of rhabdomyolysis: three case reports and review. Clin Infect Dis 1996, 22: 642-649.PubMed
86.
Armstrong J: Tropical pyomyositis and myoglobinuria. Arch Intern Med 1978, 138: 1145-1146. 10.1001/archinte.138.7.1145PubMed
87.
Malvy D, Desalles P, Monseau Y, Bonhoure J: Legionnaire's disease and rhabdomyolysis. Intensive Care Med 1992, 18: 132-133.PubMed
88.
Bagnulo H, Rodriguez F: Rhabdomyolysis during a case of streptococcal toxic shock syndrome. Enferm Infecc Microbiol Clin 2001, 19: 82-83.PubMed
89.
Naschitz J, Yeshurun D, Shagrawi I: Rhabdomyolysis in pneumococcal sepsis. Am J Med 1989, 87: 479-480. 10.1016/0002-9343(89)90672-4PubMed
90.
Pesik N, Otten E: Severe rhabdomyolysis following a viral illness: a case report and review of literature. J Emerg Med 1996, 14: 425-428. 10.1016/0736-4679(96)00078-9PubMed
91.
Fodili F, van Bommel EF: Severe rhabdomyolysis and acute renal failure following recent Coxsackie B virus infection. Neth J Med 2003, 61: 177-179.PubMed
92.
Beetham R: Biochemical investigation of suspected rhabdomyolysis. Ann Clin Biochem 2000, 37: 581-587. 10.1258/0004563001899870PubMed
93.
Abassi Z, Hoffman A, Better O: Acute renal failure as complication or muscle injury. Semin Nephrol 1998, 18: 558-565.PubMed
94.
Flamenbaum W, Gehr M, Gross M, Kaufman J, Hamburger R: Acute renal failure associated with myoglobinuria and hemoglobinuria. In In Acute Renal Failure. Edited by: Brenner B, Lazarus J. Philadelphia, PA: WB Saunders; 1983:269-282.
95.
Salahudeen A, Wang C, Bigler S, Dai Z, Tachikawa H: Synergistic renal protection by combining alkaline-diuresis with lipid peroxidation inhibitors in rhabdomyolysis: possible interaction between oxidant and non oxidant mechanisms. Nephrol Dial Transplant 1996, 11: 635-642.PubMed
96.
Zager R, Burkhart K: Differential effects of glutathione and cysteine on Fe 2+ , Fe 3+ , H 2 O 2 and myoglobin-induced proximal tubule cell attack. Kidney Int 1998, 53: 1661-1672. 10.1046/j.1523-1755.1998.00772.xPubMed
97.
Moore K, Holt S, Patel R, Zacker W, Goodier D, Reeder B: A causative role for redox cycling and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem 1998, 273: 31731-31737. 10.1074/jbc.273.48.31731PubMed
98.
Clozel M, Anand R, Cooper C, Morrow J: Resolution of muscle calcification in rhabdomyolysis and acute renal failure. Ann Intern Med 1978, 89: 928-930.
99.
Sauret J, Marinides G, Wang G: Rhabdomyolysis. Am Fam Physician 2002, 65: 907-912.PubMed
100.
Dayer-Berenson L: Rhabdomyolysis a comprehensive guide. ANNA J 1994, 21: 15-18.PubMed
101.
Akmal M, Massry S: Reversible hepatic dysfunction associated with rhabdomyolysis. Am J Nephrol 1990, 10: 49-52.PubMed
102.
Brown C, Rhee P, Chan L, Evans K, Demetriades D, Velmahos G: Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference? J Trauma 2004, 56: 1191-1196.PubMed
103.
Koppel C: Clinical features, pathogenesis and management of drug-induced rhabdomyolysis. Med Toxicol Adverse Drug Exp 1989, 4: 108-126.PubMed
104.
Adams EC: Differentiation of myoglobin and hemoglobin in biological fluids. Ann Clin Lab Sci 1980, 10: 493-499.PubMed
105.
Syrjala H, Vuori J, Huttunen K: Carbonic anhydrase III as a serum marker for the diagnosis of rhabdomyolysis [letter]. Clin Chem 1990, 36: 696.PubMed
106.
Bohlmeyer TJ, Wu AH, Perryman MB: Evaluation of laboratory tests as a guide to diagnosis and therapy of myositis. Rheum Dis Clin North Am 1994, 20: 845-856.PubMed
107.
Benoist JF, Cosson C, Mimoz O, Edouard A: Serum cardiac troponin I, creatine kinase (CK), and CK-MB in early posttraumatic rhabdomyolysis. Clin Chem 1997, 43: 416-417.PubMed
108.
Harper J: Rhabdomyolysis and acute renal failure. Crit Care Nurs 1990, 10: 32-36.
109.
Knochel J: Hypophosphatemia and rhabdomyolysis. Am J Med 1992, 92: 455-457. 10.1016/0002-9343(92)90739-XPubMed
110.
Hoogwerf B, Kern J, Bullock M, Comty C: Phencyclidine-induced rhabdomyolysis and acute renal failure. Clin Toxicol 1979, 14: 47-53.PubMed
111.
Russel T: Acute renal failure related to rhabdomyolysis: pathophysiology, diagnosis, and collaborative management. Nephrol Nurs J 2000, 27: 567-577.
112.
Hamilton R, Hopkins M, Shihabi Z: Myoglobinuria, hemoglobinuria and acute renal failure. Clin Chem 1989, 35: 1713-1720.PubMed
113.
Varon J: Practical Guide to the Care of the Critically Ill Patient. St Louis, MO: Mosby; 1994:317-319.
114.
Sinert R, Kohl L, Rainone T, Scalea T: Exercise induced rhabdomyolysis. Ann Emerg Med 1994, 23: 1301-1306.PubMed
115.
Better O, Rubinstein I: Management of shock and acute renal failure in casualties suffering from the crush syndrome. Renal Failure 1997, 19: 647-653.PubMed
116.
Curry S, Chang D, Connor D: Drug and toxin-induced rhabdomyolysis. Ann Emerg Med 1989, 18: 1068-1084.PubMed
117.
Gunal A, Celiker H, Dogukan A, Ozalp G, Kiraiman E, Simsekli H, Gunay I, Demiran M, Belhan O, Yidirim M, et al.: Early and vigorous fluid resuscitation prevents acute renal failure in the crush victims of catastrophic earthquakes. J Am Soc Nephrol 2004, 15: 1862-1867. 10.1097/01.ASN.0000129336.09976.73PubMed
118.
Luke R, Linton A, Briggs J, Kennedy A: Mannitol therapy in acute renal failure. Lancet 1965, 1: 980-982. 10.1016/S0140-6736(65)91216-XPubMed
119.
Homsi E, Barreiro M, Orlando J, Higa E: Prophylaxis of acute renal failure in patients with rhabdomyolysis. Ren Fail 1997, 19: 283-288.PubMed
120.
Zager R: Combined mannitol and deferoxamine therapy for myohemoglobinuric renal injury and oxidant tubular stress. Mechanistic and therapeutic implications. J Clin Invest 1992, 90: 711-719.PubMedCentralPubMed
121.
Conger J: Interventions in clinical acute renal failure: where are the data? Am J Kidney Dis 1995, 26: 565-576.PubMed
122.
Shilliday I, Allison M: Diuretics in acute renal failure. Ren Fail 1994, 16: 3-17.PubMed
123.
Lieberthal W, Levinsky N: Treatment of acute tubular necrosis. Semin Nephrol 1990, 10: 571-583.PubMed
124.
Thadhani R, Pascual M, Bonventre J: Acute renal failure. N Engl J Med 1996, 334: 1448-1460. 10.1056/NEJM199605303342207PubMed
125.
Eneas J, Schoenfeld P, Humphreys M: The effect of infusion of mannitol–sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med 1979, 139: 801-805. 10.1001/archinte.139.7.801PubMed
126.
Corwin H, Bonventre J: Factors influencing survival in acute renal failure. Semin Dial 1989, 2: 220-225.
127.
Ali H, Neito J, Rhamy R, Chandarlapaty S, Vaamonde C: Acute renal failure due to rhabdomyolysis associated with the extreme lithotomy position. Am J Kidney Dis 1993, 22: 865-869.PubMed
128.
Pensado A, Ferreira T, Dominguez L, Molins N: Diagnosis and treatment of rhabdomyolysis and myoglobinuria [letter]. Rev Esp Anestesiol Reanim 1996, 43: 263.PubMed
129.
130.
Ron D, Taitelman U, Michaelson M, Bar-Joseph G, Bursztein S, Better O: Prevention of acute renal failure in traumatic rhabdomyolysis. Arch Intern Med 1984, 144: 277-280. 10.1001/archinte.144.2.277PubMed
131.
Mathes D, Assimos D, Donfrio P: Rhabdomyolysis and myonecrosis in a patient in the lateral decubitus position. Anaesthesioogy 1996, 84: 727-729. 10.1097/00000542-199603000-00030
132.
Marik PE, Kussman BD, Lipman J, Kraus P: Acetazolamide in the treatment of metabolic alkalosis in critically ill patients. Heart Lung 1991, 20: 455-459.PubMed
133.
Knochel J, Moore G: Rhabdomyolysis in malaria. N Engl J Med 1993, 329: 1206-1207. 10.1056/NEJM199310143291618PubMed
134.
Knottenbelt J: Traumatic rhabdomyolysis from severe beating experience of volume diuresis in 200 patients. J Trauma 1994, 37: 214-219.PubMed
135.
Owen C, Mubarak S, Hargens A: Intramuscular pressures with limb compression. Clarification of the drug-induced muscle-compartment syndrome. N Engl J Med 1979, 300: 1169-1172.PubMed
136.
Walker P, Lindsay T, Labbe R, Mickle D, Romaschin A: Salvage of skeletal muscle with free radical scavengers. J Vasc Surg 1987, 5: 68-75. 10.1067/mva.1987.avs0050068PubMed
137.
Youn Y, LaLonde C, Dremling R: Use of antioxidant therapy in shock and trauma. Circ Shock 1991, 35: 245-249.PubMed
138.
Mandell G: ARDS, neutrophils, and pentoxifylline. Am Rev Resp Dis 1988, 136: 1103-1105.
139.
Maclin L: Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987, 1: 441-445.
140.
Braughler J, Pregenzer J, Chase R, Duncan L, Jacobsen E, McCall J: Novel 21-aminosteroids as potent inhibitors of iron dependent lipid preoxidation. J Biol Chem 1987, 262: 1438-1440.
141.
Homsi E, Barreiro M, Orlando J, Higa E: Prophylaxis of acute renal failure in patients with rhabdomyolysis. Ren Fail 1997, 19: 283-288.PubMed
142.
Forni L, Hilton P: Continuous hemofiltration in the treatment of acute renal failure. N Engl J Med 1997, 336: 1303-1309. 10.1056/NEJM199705013361807PubMed
143.
Oda J, Tanaka H, Yoshioka T, Iwai A, Yamamura H, Ishikawa K, Matsuoka T, Kuwagata Y, Hiraide A, Shimazu T, et al.: Analysis of 372 patients with crush syndrome caused by Hanshin-Awaji earthquake. J Trauma 1997, 42: 470-476.PubMed
144.
Nolph K, Qhitcomb M, Schrier R: Mechanisms for inefficient peritoneal dialysis in acute renal failure associated with heat and exercise. Ann Intern Med 1969, 71: 317-336.PubMed
145.
Vanholder R, Sever M, Erek E, Lameire N: Rhabdomyolysis. J Am Soc Nephrol 2000, 11: 1553-1561.PubMed
146.
Llach F, Felsenfeld A, Haussler M: The pathophysiology of altered calcium metabolism in rhabdomyolysis induced acute renal failure. Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihidroxycholecalciferol. N Engl J Med 1981, 305: 117-123.PubMed
147.
Akmal M, Bishop J, Telfer N, Norman A, Massry S: Hypocalcemia and hypercalcemia in patients with rhabdomyolysis and without acute renal failure. J Clin Endocrinol Metab 1986, 63: 137-142.PubMed
148.
Bilezikian JP: Clinical review 51: management of hypercalcemia. J Clin Endocrinol Metab 1993, 77: 1445-1449. 10.1210/jc.77.6.1445PubMed
149.
Bourke E, Delaney V: Assessment of hypocalcemia and hypercalcemia. Clin Lab Med 1993, 13: 157-181.PubMed
150.
Metadata
Title
Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians
Authors
Ana L Huerta-Alardín
Joseph Varon
Paul E Marik
Publication date
01-04-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2978

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