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Published in: Critical Care 2/2005

01-04-2005 | Commentary

Human endotoxemia and human sepsis: limits to the model

Authors: Ramon Anel, Anand Kumar

Published in: Critical Care | Issue 2/2005

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Abstract

Sepsis remains the most common cause of death in intensive care units of the developed world. Accurate models of this disease syndrome are crucial for to the understanding of the complex pathophysiology of this disorder. The administration of a small dose of lipopolysaccharide to healthy volunteers is one such model of spontaneous human sepsis. Although this human endotoxemia model appears to be reasonably effective in mimicking early biochemical, metabolic, hematologic and cardiovascular septic responses in septic shock, the ability to mimic other aspects of human sepsis is open to question. The current study demonstrates that human experimental endotoxemia fails to generate evidence of increased vascular permeability within the relatively short time frame of the study.
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Metadata
Title
Human endotoxemia and human sepsis: limits to the model
Authors
Ramon Anel
Anand Kumar
Publication date
01-04-2005
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3501

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