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Published in: Critical Care 1/2005

01-02-2004 | Review

Science review: The brain in sepsis – culprit and victim

Authors: Tarek Sharshar, Nicholas S Hopkinson, David Orlikowski, Djillali Annane

Published in: Critical Care | Issue 1/2005

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Abstract

On one side, brain dysfunction is a poorly explored complication of sepsis. On the other side, brain dysfunction may actively contribute to the pathogenesis of sepsis. The current review aimed at summarizing the current knowledge about the reciprocal interaction between the immune and central nervous systems during sepsis. The immune-brain cross talk takes part in circumventricular organs that, being free from blood-brain-barrier, interface between brain and bloodstream, in autonomic nuclei including the vagus nerve, and finally through the damaged endothelium. Recent observations have confirmed that sepsis is associated with excessive brain inflammation and neuronal apoptosis which clinical relevance remains to be explored. In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction.
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Metadata
Title
Science review: The brain in sepsis – culprit and victim
Authors
Tarek Sharshar
Nicholas S Hopkinson
David Orlikowski
Djillali Annane
Publication date
01-02-2004
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2005
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc2951

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