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Open Access 01-06-2014 | Research

Inflammation biomarkers and delirium in critically ill patients

Authors: Cristiane Ritter, Cristiane D Tomasi, Felipe Dal-Pizzol, Bernardo Bollen Pinto, Alex Dyson, Aline S de Miranda, Clarissa M Comim, Márcio Soares, Antonio L Teixeira, João Quevedo, Mervyn Singer

Published in: Critical Care | Issue 3/2014

Abstract

Introduction

Delirium is a common occurrence in critically ill patients and is associated with an increase in morbidity and mortality. Septic patients with delirium may differ from a general critically ill population. The aim of this investigation was to study the relationship between systemic inflammation and the development of delirium in septic and non-septic critically ill patients.

Methods

We performed a prospective cohort study in a 20-bed mixed intensive care unit (ICU) including 78 (delirium = 31; non-delirium = 47) consecutive patients admitted for more than 24 hours. At enrollment, patients were allocated to septic or non-septic groups according to internationally agreed criteria. Delirium was diagnosed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) during the first 72 hours of ICU admission. Blood samples were collected within 12 hours of enrollment for determination of tumor necrosis factor (TNF)-α, soluble TNF Receptor (STNFR)-1 and -2, interleukin (IL)-1β, IL-6, IL-10 and adiponectin.

Results

Out of all analyzed biomarkers, only STNFR1 (P = 0.003), STNFR2 (P = 0.005), adiponectin (P = 0.005) and IL-1β (P < 0.001) levels were higher in delirium patients. Adjusting for sepsis and sedation, these biomarkers were also independently associated with delirium occurrence. However, none of them were significant influenced by sepsis.

Conclusions

STNFR1, STNFR2, adiponectin and IL-1β were associated with delirium. Sepsis did not modify the relationship between the biomarkers and delirium occurrence.

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Title: Inflammation biomarkers and delirium in critically ill patients
Authors: Cristiane Ritter
Cristiane D Tomasi
Felipe Dal-Pizzol
Bernardo Bollen Pinto
Alex Dyson
Aline S de Miranda
Clarissa M Comim
Márcio Soares
Antonio L Teixeira
João Quevedo
Mervyn Singer
Publication date: 01-06-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc13887

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Inflammation biomarkers and delirium in critically ill patients

Abstract

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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