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Critical Care
Published in: Critical Care 5/2013

01-10-2013 | Commentary

Adipose tissue alterations in critical illness: a paradox as to patient outcomes

Author: Charles E Wade

Published in: Critical Care | Issue 5/2013

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Abstract

Adipocyte morphological changes in critically ill patients have been reported, potentially providing beneficial effects. Marques and colleagues reported that these morphological adipocyte changes, as well as accumulation of M2 phenotype macrophages, occur irrespective of nutritional status in the critically ill. The present study provides insight into the alterations that occur, although further studies are needed to fully understand the role that adipose tissue plays in the critically injured.
Literature
1.
Marques MB, Perre SV, Aertgeerts A, Derde S, Guiza F, Casaer MP, Hermans G, Van den Berghe G, Langouche L: Critical illness induces nutrient-independent adipogenesis and accumulation of alternatively activated tissue macrophages. Crit Care 2013. in press
2.
Marques MB, Langouche L: Endocrine, metabolic, and morphologic alterations of adipose tissue during critical illness. Crit Care Med 2013, 41: 317-325.CrossRefPubMed
3.
Langouche L, Marques MB, Ingels C, Gunst J, Derde S, Vander Perre S, D'Hoore A, Van den Berghe G: Critical illness induces alternative activation of M2 macrophages in adipose tissue. Crit Care 2011, 15: R245. 10.1186/cc10503PubMedCentralCrossRefPubMed
4.
Alberda C, Gramlich L, Jones N, Jeejeebhoy K, Day AG, Dhaliwal R, Heyland DK: The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 2009, 35: 1728-1737. 10.1007/s00134-009-1567-4CrossRefPubMed
5.
Jan BV, Lowery SF: Systemic response to injury and metabolic support. In Schwartz's Principles of Surgery. 9th edition. Edited by: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock RE. New York: McGraw-Hill Companies Inc; 2010:16-49.
6.
Long C: Energy expenditure of major burns. J Trauma 1979, 19: 904-906.PubMed
7.
Langouche L, Perre SV, Thiessen S, Gunst J, Hermans G, D'Hoore A, Kola B, Korbonits M, Van den Berghe G: Alterations in adipose tissue during critical illness: an adaptive and protective response? Am J Respir Crit Care Med 2010, 182: 507-516. 10.1164/rccm.200909-1395OCCrossRefPubMed
Metadata
Title
Adipose tissue alterations in critical illness: a paradox as to patient outcomes
Author
Charles E Wade
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13013

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