Top

Published in:

01-06-2012 | Commentary

Down but not out: myocardial depression in sepsis

Author: Anthony S McLean

Published in: Critical Care | Issue 3/2012

Abstract

Myocardial depression in septic patients is well recognized yet still poorly understood. The prognostic significance in terms of overall mortality when it is identified, remains in dispute. Parameters of left ventricular function measured by tissue Doppler imaging may assist in resolving whether dysfunction identified early in the course of sepsis is a good prognostic sign.

Weng L, Liu YT, Du B, Zhou JF, Guo XX, Peng JM, Hu XY, Zhang SY, Fang Q, Zhu WL: The Prognostic value of left ventricular systolic function as measured by tissue Doppler imaging in septic shock. Crit Care 2012, 16: R71. 10.1186/cc11328PubMedCentralCrossRefPubMed

Parker MM, Suffredini AF, Natanson C, Ognibene FP, Shelhamer JH, Parrillo JE: Responses of left ventricular function in survivors and nonsurvivors of septic shock. J Crit Care 1989, 4: 19-25. 10.1016/0883-9441(89)90087-7CrossRef

Vieillard-Baron A, Caille V, Charron C, Belliard G, Page B, Jardin F: Actual incidence of global left ventricular hypokinesia in adult septic shock. Crit Care Med 2008, 36: 1701-1706. 10.1097/CCM.0b013e318174db05CrossRefPubMed

Vieillard-Baron A: Septic cardimyopathy. Ann Intensive Care 2011, 1: 6. 10.1186/2110-5820-1-6PubMedCentralCrossRefPubMed

Hunter JD, Doddi M: Sepsis and the heart. Brit J Anaesthesia 2010, 104: 3-11. 10.1093/bja/aep339CrossRef

Sturgess DJ, Marwick TH, Joyce C, Jenkins C, Jones M, Masci P, Stewart D, Venkatesh B: Prediction of hospital outcome in septic shock: a prospective comparison of tissue Doppler and cardiac biomarkers. Crit Care 2010, 14: R44. 10.1186/cc8931PubMedCentralCrossRefPubMed

Landesberg G, Gilon D, Meroz Y, Georgieva M, Levin PD, Goodman S, Avidan A, Beeri R, Weissman C, Jaffe AS, Sprung CL: Diastolic dysfunction and mortality in septic shock. Eur Heart J 2012, 33: 895-903. 10.1093/eurheartj/ehr351PubMedCentralCrossRefPubMed

Wiggers CJ: Myocardial depressant factor in shock. A survey of cardiodynamic studies. Am Heart J 1947, 33: 633-650. 10.1016/0002-8703(47)90079-3CrossRefPubMed

Parillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W: A circulating myocardial depressant substance in humans with septic shock. Septic patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985, 76: 1539-1553. 10.1172/JCI112135CrossRef

10.

Flynn A, Mani BC, Mather PJ: Sepsis-induced cardiomyopathy:a review of pathophysiologic mechanisms. Heart Fail Rev 2010, 15: 605-611. 10.1007/s10741-010-9176-4CrossRefPubMed

11.

Chahal NS, Lim TK, Jain P, Chambers JC, Kooner JS, Senior R: Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study. Eur J Echocardiogr 2010, 11: 51-56. 10.1093/ejechocard/jep164CrossRefPubMed

Title: Down but not out: myocardial depression in sepsis
Author: Anthony S McLean
Publication date: 01-06-2012
Publisher: BioMed Central
Published in: Critical Care / Issue 3/2012
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc11367

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Down but not out: myocardial depression in sepsis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2012

The importance of colonization pressure in multiresistant Acinetobacter baumannii acquisition in a Greek intensive care unit

Early versus late parenteral nutrition in ICU patients: cost analysis of the EPaNIC trial

ROTEM®-guided coagulation factor concentrate therapy in trauma: 2-year experience in Venice, Italy

Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock

The effect of earplugs during the night on the onset of delirium and sleep perception: a randomized controlled trial in intensive care patients

Bivalirudin and post-cardiotomy ECMO: a word of caution