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Breast Cancer Research
Published in: Breast Cancer Research 4/2000

01-08-2000 | Commentary

Acetyltransferases and tumour suppression

Authors: Andrew C Phillips, Karen H Vousden

Published in: Breast Cancer Research | Issue 4/2000

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Abstract

The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recentl publication by Gayther et al, which strongly supports a role for p300 as a tumour suppressor. The authors identify truncating mutations associated with the loss or mutation of the second allele in both tumour samples and cell lines, suggesting that loss of p300 may play a role in the development of a subset of human cancers.
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Metadata
Title
Acetyltransferases and tumour suppression
Authors
Andrew C Phillips
Karen H Vousden
Publication date
01-08-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 4/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr63

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