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Breast Cancer Research
Published in: Breast Cancer Research 1/2013

01-02-2013 | Viewpoint

Unraveling the 'TGF-β paradox' one metastamir at a time

Authors: Danny R Welch, Douglas R Hurst

Published in: Breast Cancer Research | Issue 1/2013

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Abstract

Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performed global miRNA expression analyses using a murine mammary carcinoma progression model. They discovered multiple miRNA regulated by TGF-β and matrix stiffness. Focusing on miR-181a, they uncovered an intricate pathway regulating breast cancer metastasis that sheds new insight into metastasis regulation that may prove useful in clinical settings.
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Taylor MA, Sossey-Alaoui K, Thompson CL, Danielpour D, Schiemann WP: TGF-beta upregulates miR-181a expression to promote breast cancer metastasis. J Clin Invest. 2013, 123: 150-163. 10.1172/JCI64946.CrossRefPubMed
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Hurst DR, Edmonds MD, Welch DR: Metastamir: the field of metastasis-regulatory microRNA is spreading. Cancer Res. 2009, 69: 7495-7498. 10.1158/0008-5472.CAN-09-2111.CrossRefPubMedPubMedCentral
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Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR: Breast cancer metastasis suppressor 1 BRMS1 up-regulates miR-146 that suppresses breast cancer metastasis. Cancer Res. 2009, 69: 1279-1283. 10.1158/0008-5472.CAN-08-3559.CrossRefPubMedPubMedCentral
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Edmonds MD, Hurst DR, Vaidya KS, Stafford LJ, Chen D, Welch DR: Breast cancer metastasis suppressor 1 (BRMS1) coordinately regulates metastasis-associated microRNA expression. Int J Cancer. 2009, 125: 1778-1785. 10.1002/ijc.24616.CrossRefPubMedPubMedCentral
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Metadata
Title
Unraveling the 'TGF-β paradox' one metastamir at a time
Authors
Danny R Welch
Douglas R Hurst
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2013
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3383

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