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Breast Cancer Research
Published in: Breast Cancer Research 6/2012

01-12-2012 | Viewpoint

MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression

Authors: Sven Rottenberg, Jos Jonkers

Published in: Breast Cancer Research | Issue 6/2012

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Abstract

Lack of eradication of disseminated breast cancer by chemotherapy is a central clinical problem. Even tumors that show substantial shrinkage after drug treatment frequently relapse and eventually become refractory to all drugs available. The mechanisms underlying this lack of eradication are largely undefined and it is therefore difficult to develop curative strategies using systemic anti-cancer therapy. In a recent article low DUSP4 expression was reported to activate RAS-ERK signaling in residual breast cancer after neoadjuvant chemotherapy. This may be a druggable characteristic because MEK inhibition increases docetaxel sensitivity in a xenograft model.
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Metadata
Title
MEK inhibition as a strategy for targeting residual breast cancer cells with low DUSP4 expression
Authors
Sven Rottenberg
Jos Jonkers
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2012
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3327

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