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Breast Cancer Research
Published in: Breast Cancer Research 6/2012

01-12-2012 | Viewpoint

Who do they think they are? Wnt-responsive cells reveal their family trees

Authors: Liliana Ordonez, Matthew J Smalley

Published in: Breast Cancer Research | Issue 6/2012

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Abstract

The nature of stem and progenitor cells in the mammary epithelium, and the relevance of cleared fat pad transplantation as a functional assay for them, has been thrown into doubt by recent lineage-tracking studies. Now two new studies based on tracking the progeny of Wnt-responsive cells are starting to help make sense of this fascinating problem.
Literature
1.
DeOme KB, Faulkin LJ, Bern HA, Blair PB: Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 1959, 19: 515-520.PubMed
2.
Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE: Generation of a functional mammary gland from a single stem cell. Nature. 2006, 439: 84-88. 10.1038/nature04372.CrossRefPubMed
3.
Sleeman KE, Kendrick H, Ashworth A, Isacke CM, Smalley MJ: CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells. Breast Cancer Res. 2006, 8: R7-10.1186/bcr1371.CrossRefPubMed
4.
Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, Li HI, Eaves CJ: Purification and unique properties of mammary epithelial stem cells. Nature. 2006, 439: 993-997.PubMed
5.
Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ: c-Kit is required for growth and survival of the cells of origin of Brca1-mutationassociated breast cancer. Oncogene. 2012, 31: 869-883. 10.1038/onc.2011.289.CrossRefPubMed
6.
Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C: Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011, 479: 189-193. 10.1038/nature10573.CrossRefPubMed
7.
Boulanger CA, Wagner KU, Smith GH: Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression. Oncogene. 2005, 24: 552-560. 10.1038/sj.onc.1208185.CrossRefPubMed
8.
van Amerongen R, Bowman AN, Nusse R: Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 2012, 11: 387-400. 10.1016/j.stem.2012.05.023.CrossRefPubMed
9.
de Visser KE, Ciampricotti M, Michalak EM, Tan DW, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J: Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. J Pathol. 2012, 228: 300-309. 10.1002/path.4096.CrossRefPubMed
10.
Williams JM, Daniel CW: Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis. Dev Biol. 1983, 97: 274-290. 10.1016/0012-1606(83)90086-6.CrossRefPubMed
11.
Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L: Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell. 2003, 4: 371-382. 10.1016/S1534-5807(03)00054-6.CrossRefPubMed
12.
Daniel CW, Silberstein GB: Postnatal development of the rodent mammary gland. The Mammary Gland: Development, Regulation and Function. Edited by: Neville MC, Daniel CW. 1987, New York: Plenum, 3-36.CrossRef
Metadata
Title
Who do they think they are? Wnt-responsive cells reveal their family trees
Authors
Liliana Ordonez
Matthew J Smalley
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2012
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr3351

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