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Breast Cancer Research
Published in: Breast Cancer Research 5/2001

01-10-2001 | Review

Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

Authors: Nicholas S Brown, Roy Bicknell

Published in: Breast Cancer Research | Issue 5/2001

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Abstract

Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma.
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Metadata
Title
Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer
Authors
Nicholas S Brown
Roy Bicknell
Publication date
01-10-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 5/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr315

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