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Breast Cancer Research
Published in: Breast Cancer Research 6/2011

01-12-2011 | Review

Clinical relevance and biology of circulating tumor cells

Authors: Natalia Bednarz-Knoll, Catherine Alix-Panabières, Klaus Pantel

Published in: Breast Cancer Research | Issue 6/2011

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Abstract

Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.
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Metadata
Title
Clinical relevance and biology of circulating tumor cells
Authors
Natalia Bednarz-Knoll
Catherine Alix-Panabières
Klaus Pantel
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2940

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