Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 3/2001

01-06-2001 | Review

Applications of microarray technology in breast cancer research

Author: Colin S Cooper

Published in: Breast Cancer Research | Issue 3/2001

Login to get access

Abstract

Microarrays provide a versatile platform for utilizing information from the Human Genome Project to benefit human health. This article reviews the ways in which microarray technology may be used in breast cancer research. Its diverse applications include monitoring chromosome gains and losses, tumour classification, drug discovery and development, DNA resequencing, mutation detection and investigating the mechanism of tumour development.
Literature
1.
Bassett DE, Eisen MB, Boguski MS: Gene expression informatics - its all in your mine. Nat Genet. 1999, 21 (suppl): 51-55. 10.1038/4478.CrossRef
2.
3.
Chee M, Yang R, Hubbel E, Berno A, Huang XC, Stern D, Winkler J, Lockhart DJ, Morris MS, Fodor SP: Accessing genetic information with high-density DNA arrays. Science. 1996, 274: 610-614. 10.1126/science.274.5287.610.CrossRefPubMed
4.
Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittman M, Wang C, Kobayashi M, Horton H, Brown EL: Expression monitoring by hybridisation to high-density oligonucleotide arrays. Nat Biotechnol. 1996, 14: 1675-1680.CrossRefPubMed
5.
Lipshutz RJ, Fodor SPA, Gingeras TR, Lockhart DJ: High density synthetic oligonucleotide arrays. Nat Genet. 1999, 21 (suppl): 20-24. 10.1038/4447.CrossRef
6.
Schena M, Shalon D, Heller R, Chai A, Brown PO, Davis RW: Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes. Proc Natl Acad Sci USA. 1996, 93: 10614-10619. 10.1073/pnas.93.20.10614.CrossRefPubMedPubMedCentral
7.
DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, Chen Y, Su YA, Trent JM: Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet. 1996, 14: 457-460.CrossRefPubMed
8.
Okamoto T, Suzuki T, Yamamoto N: Microarray fabrication with covalent attachment of DNA using bubble jet technology. Nat Biotechnol. 2000, 18: 438-441. 10.1038/74507.CrossRefPubMed
9.
Radtkey R, Feng L, Muralhidar M, Duhon M, Canter D, DiPierro D, Fallon S, Tu E, McElfresh K, Nerenberg M, Sosnowski R: Rapid, high fidelity analysis of simple sequence repeats on an electronically active DNA microchip. Nucleic Acids Res. 2000, 28: E17-E17. 10.1093/nar/28.7.e17.CrossRefPubMedPubMedCentral
10.
Drmanac S, Drmanac R: Processing of cDNA and genomic kilobase-size clones for massive screening, mapping and sequencing by hybridisation. Biotechniques. 1994, 17: 328-336.PubMed
11.
Drmanac S, Stavropoulos NA, Labat I, Vonau J, Hauser B, Soares MD, Drmanac R: Gene-representing cDNA clusters defined by hybridisation of 57,419 clones from infant brain libraries with short oligonucleotide probes. Genomics. 1996, 37: 29-40. 10.1006/geno.1996.0517.CrossRefPubMed
12.
Milosavljevic A, Savkovic S, Crkvenjakov R, Salbego D, Serrato H, Kreuzer H, Gemmell A, Batus S, Grujic D, Carnahan S, Paunesku T, Tepavcevic J: DNA sequence recognition by hybridisations to short oligomers: experimental verification of the method on the E. coli genome. Genomics. 1996, 37: 77-86. 10.1006/geno.1996.0523.CrossRefPubMed
13.
Yershov G, Barsky V, Belgovskiy A, Kirillov E, Kreindlin E, Ivanov I, Parinov S, Guschin D, Drobishev A, Dubiley S, Mirzabekov A: DNA analysis and diagnostics on oligonucleotide microchips. Proc Natl Acad Sci USA. 1996, 93: 4913-4918. 10.1073/pnas.93.10.4913.CrossRefPubMedPubMedCentral
14.
Southern E, Mir K, Shchepinov M: Molecular interactions on microarrays. Nat Genet. 1999, 21 (suppl): 5-9. 10.1038/4429.CrossRef
15.
Cheung VG, Morley M, Aguilar F, Massimi A, Kucherlapati R, Childs G: Making and reading microarrays. Nat Genet. 1999, 21: 15-19. 10.1038/4439.CrossRefPubMed
16.
Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D: Light-directed, spatially addressable parallel chemical synthesis. Science. 1991, 251: 767-773.CrossRefPubMed
17.
Pease AC, Solas D, Sullivan EJ, Cronin MT, Holmes CP, Fodor SP: Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA. 1994, 91: 5022-5026.CrossRefPubMedPubMedCentral
18.
McGall G, Labadie J, Brock P, Wallraff G, Nguyen T, Hinsberg W: Light-directed synthesis of high density oligonucleotide arrays using semiconductor photoresists. Proc Natl Acad Sci USA. 1996, 93: 13555-13560. 10.1073/pnas.93.24.13555.CrossRefPubMedPubMedCentral
19.
Hacia JG, Woski SA, Fidanza J, Edgemon K, Hunt N, McGall G, Fodor SP, Collins FS: Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates. Nucleic Acids Res. 1998, 26: 4975-4982. 10.1093/nar/26.21.4975.CrossRefPubMedPubMedCentral
20.
Brinkmann U, Gallo M, Polymeropoulos MH, Pastan I: The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. Genome Res. 1996, 6: 187-194.CrossRefPubMed
21.
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 1997, 277: 965-968. 10.1126/science.277.5328.965.CrossRefPubMed
22.
Sen S, Zhou H, White RA: A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene. 1997, 14: 2195-2200. 10.1038/sj/onc/1201065.CrossRefPubMed
23.
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987, 235: 177-182.CrossRefPubMed
24.
Gusterson BA, Gelber RD, Goldhirsch A, Price KN, Save-Soderborgh J, Anbazhagan R, Styles J, Rudenstam CM, Golouh R, Reed R: Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. J Clin Oncol. 1992, 10: 1049-1056.PubMed
25.
Tanner MM, Tirkkonen M, Kallioniemi A, Holli K, Collins C, Kowbel D, Gray JW, Kallioniemi O-P, Isola J: Amplification of chromosomal region 20q13 in invasive breast cancer: prognostic implications. ClinCancer Res. 1995, 1: 1455-1461.
26.
Forozan F, Karhu R, Kononen J, Kallioniemi A, Kallioniemi O-P: Genome screening by comparative genomic hybridisation. Trends Genet. 1997, 13: 405-409. 10.1016/S0168-9525(97)01244-4.CrossRefPubMed
27.
Pinkel D, Segraves R, Sudar D, Clark S, Poole I, Kowbel D, Collins C, Kuo W-L, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG: High resolution analysis of DNA copy number variation using comparative genomic hybridisation to microarrays. Nat Genet. 1998, 20: 207-211. 10.1038/2524.CrossRefPubMed
28.
Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, Williams CF, Jeffrey SS, Botsein D, Brown PO: Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet. 1999, 23: 41-46. 10.1038/12640.CrossRefPubMed
29.
Heiskanen MA, Bittner M, Chen Y, Khan J, Adler KE, Trent JM, Meltzer PS: Detection of gene amplification by genomic hybridisation to cDNA microarrays. Cancer Res. 2000, 60: 799-802.PubMed
30.
Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES: Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999, 286: 531-537. 10.1016/S0378-4371(00)00404-0.CrossRefPubMed
31.
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J, Lu L, Lewis DB, Tibshirani R, Sherlock G, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Warnke R, Staudt LM: Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000, 403: 503-511. 10.1038/35000501.CrossRefPubMed
32.
Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO: Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet. 2000, 24: 227-235. 10.1038/73432.CrossRefPubMed
33.
Alon U, Barkai N, Notterman DA, Gish K, Mack YD, Levine AJ: Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci USA. 1999, 96: 6745-6750. 10.1073/pnas.96.12.6745.CrossRefPubMedPubMedCentral
34.
Sgroi DC, Teng S, Robinson G, LeVangie R, Hudson JR, Elkahloun AG: In vivo gene expression profile analysis of human breast cancer progression. Cancer Res. 1999, 59: 5656-5661.PubMed
35.
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D: Molecular portraits of human breast tumours. Nature. 2000, 406: 747-752. 10.1038/35021093.CrossRefPubMed
36.
Debouck C, Goodfellow PN: DNA microarrays in drug discovery and development. Nat Genet. 21: 48-50. 10.1038/4475.
37.
Scherf U, Ross DT, Waltham M, Smith LH, Lee JK, Tanabe L, Kohn KW, Reinhold WC, Myers TG, Andrews DT, Scudiero DA, Eisen MB, Sausville EA, Pommier Y, Botstein D, Brown PO, Weinstein JN: A gene expression database for the molecular pharmacology of cancer. Nat Genet. 2000, 24: 236-244. 10.1038/73439.CrossRefPubMed
38.
Marton MJ, DeRisi JL, Bennett HA, Iyer VR, Meyer MR, Roberts CJ, Stoughton R, Burchard J, Slade D, Dai H, Bassett DE, Hartwell LH, Brown PO, Friend SH: Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat Med. 1998, 4: 1293-1301. 10.1038/3282.CrossRefPubMed
39.
Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, Armour CD, Bennett HA, Coffey E, Dai H, He YD, Kidd MJ, King AM, Meyer MR, Slade D, Lum PY, Stepaniants SB, Shoemaker DD, Gachotte D, Chakraburtty K, Simon J, Bard M, Friend SH: Functional discovery via a compemdium of expression profiles. Cell. 2000, 102: 109-126. 10.1016/S0092-8674(00)00015-5.CrossRefPubMed
40.
Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG: Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998, 281: 533-538. 10.1007/s004410050449.CrossRefPubMed
41.
Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I, Workman P: Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone. Oncogene. 2000, 19: 4125-4133. 10.1038/sj/onc/1203753.CrossRefPubMed
42.
Hacia JG, Brody LC, Chee MS, Fodor SPA, Collins FS: Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet. 1996, 14: 441-447.CrossRefPubMed
43.
Hacia JG: Resequencing and mutational analysis using oligonucleotide microarrays. Nat Genet. 1999, 21 (suppl): 42-47. 10.1038/4469.CrossRef
44.
Ahrendt SA, Halachmi S, Chow JT, Wu L, Halachmi N, Yang SC, Wehage S, Jen J, Sidransky D: Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array. Proc Natl Acad Sci USA. 1999, 96: 7382-7387. 10.1073/pnas.96.13.7382.CrossRefPubMedPubMedCentral
45.
Lehman TA, Haffty BG, Carbone CJ, Bishop LR, Gumbs AA, Krishnan S, Shields PG, Modali R, Turner BC: Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer. Cancer Res. 2000, 60: 1062-1069.PubMed
46.
Wen W-H, Bernstein L, Lescallett J, Beazer-Barclay Y, Sullivan-Halley J, White M, Press MF: Comparison of TP53 mutations identified by oligonucleotide microarray and conventional DNA sequence analysis. Cancer Res. 2000, 60: 2716-2722.PubMed
47.
Wilson JW, Bean P, Robins T, Graziano F, Persing DH: Comparative evaluation of three human immunodeficiency virus genotyping systems: the HIV-Genotype R method, the HIV PRT GeneChip assay and the HIV RT line probe assay. J Clin Microbiol. 2000, 38: 3022-3028.PubMedPubMedCentral
48.
Syvanen AC: From gels to chips: 'Minisequencing' primer extension for analysis of point mutations and single nucleotide polymorphisms. Hum Mut. 1999, 13: 1-10. 10.1002/(SICI)1098-1004(1999)13:1<1::AID-HUMU1>3.3.CO;2-9.CrossRefPubMed
49.
Favis R, Day JP, Gerry NP, Phelan C, Narod S, Barany F: Universal DNA array detection of small insertsions and deletions in BRCA1 and BRCA2. Nat Biotechnol. 2000, 18: 561-564. 10.1038/75452.CrossRefPubMed
50.
Gerry NP, Witowski NE, Day J, Hammer RP, Barany G, Barany F: Universal DNA microarray method for multiplex detection of low abundance point mutations. J Mol Biol. 1999, 292: 251-262. 10.1006/jmbi.1999.3063.CrossRefPubMed
51.
Gerry NP, Witowski NE, Day J, Hammer RP, Barany G, Barany F: Universal DNA microarray method for multiplex detection of low abundance point mutations. J Mol Biol. 1999, 292: 251-262. 10.1006/jmbi.1999.3063.CrossRefPubMed
52.
Favis R, Barany F: Mutation detection in K-ras, BRCA1, BRCA2, and p53 using PCR/LDR and a universal DNA microarray. Annls NY Acad Sci. 2000, 906: 39-43.CrossRef
53.
Khan J, Bittner M, Saal LH, Teichmann U, Azorsa DO, Gooden GC, Pavan WJ, Trent JM, Meltzer PS: cDNA miroarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. Proc Natl Acad Sci USA. 1999, 96: 13264-13269. 10.1073/pnas.96.23.13264.CrossRefPubMedPubMedCentral
54.
Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliver JD, Haber DA: Induction of GADD45 and JNK/SAPK-Dependent apoptosis following inducible exprssion of BRCA1. Cell. 1999, 97: 575-586. 10.1016/S0092-8674(00)80769-2.CrossRefPubMed
55.
Coller HA, Grandori C, Tamayo P, Colbert T, Lander ES, Eisenman RN, Golub TD: Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth cell cycle signaling and adhesion. Proc Natl Acad Sci USA. 2000, 97: 3260-3265. 10.1073/pnas.97.7.3260.CrossRefPubMedPubMedCentral
56.
57.
Zhao R, Gish K, Murphy M, Yuxin Y, Nottermann D, Hoffman WH, Tom E, Mack DH, Levine AJ: Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000, 14: 981-993. 10.1101/gad.827700.CrossRefPubMedPubMedCentral
58.
59.
Amundson SA, Bittner M, Chen Y, Trent J, Meltzer P, Forance AJ: Fluorescent cDNA microarray hybridisation reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene. 1999, 18: 3666-3672. 10.1038/sj/onc/1202676.CrossRefPubMed
60.
Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA: Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proc Natl Acad Sci USA. 2000, 97: 2680-2685. 10.1073/pnas.97.6.2680.CrossRefPubMedPubMedCentral
61.
Johannes G, Carter MS, Eisen MB, Brown PO, Sarnow P: Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Proc Natl Acad Sci USA. 1999, 96: 13118-13123. 10.1073/pnas.96.23.13118.CrossRefPubMedPubMedCentral
62.
Diehn M, Eisen MB, Botstein D, Brown PO: Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. Nat Genet. 25: 58-62. 10.1038/75603.
63.
64.
Perou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC, Lashkari D, Shalon D, Brown PO, Botstein D: Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci USA. 1999, 96: 9212-9217. 10.1073/pnas.96.16.9212.CrossRefPubMedPubMedCentral
65.
Rusiniak ME, Yu M, Ross DT, Tolhurst EC, Slack JL: Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia. Cancer Res. 2000, 60: 1824-1829.PubMed
66.
Ollila J, Vihinen M: Stimulation of B and T cells activates expression of transcription and differentiation factors. Biochem Biophys Res Commun. 1998, 249: 475-480. 10.1006/bbrc.1998.9176.CrossRefPubMed
67.
Teague TK, Hildeman D, Kedl RM, Mitchell T, Rees W, Schaefer BC, Bender J, Kappler J, Marrack P: Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci USA. 1999, 96: 12691-12696. 10.1073/pnas.96.22.12691.CrossRefPubMedPubMedCentral
68.
Rogge L, Bianchi E, Biffi M, Bono E, Chang SY, Alexander H, Santini C, Ferrari G, Sinigaglia L, Seiler M, Neeb M, Mous J, Sini-gaglia F, Certa U: Transcript imaging of the development of human T helper cells using oligonucleotide arrays. Nat Genet. 2000, 25: 96-101. 10.1038/75671.CrossRefPubMed
69.
Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson J, Boguski MS, Lashkari D, Shalon D, Botstein D, Brown PO: The transcriptional program in the response of human fibroblasts to serum. Science. 1999, 283: 83-87. 10.1006/abio.2000.4611.CrossRefPubMed
70.
Pendurthi UR, Allen KE, Ezban M, Rao LV: Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa tissue factor-induced signal transduction. J Biol Chem. 2000, 275: 14632-14641. 10.1074/jbc.275.19.14632.CrossRefPubMed
71.
Der SD, Zhou A, Williams BRG, Silverman RH: Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays. Proc Natl Acad Sci USA. 1998, 26: 15623-15628. 10.1073/pnas.95.26.15623.CrossRef
72.
Jbilo O, Derocq JM, Segui M, Le Fur G, Casellas P: Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60. FEBS Lett. 1999, 448: 273-277. 10.1016/S0014-5793(99)00380-4.CrossRefPubMed
73.
Lin B, Ferfuson C, White JT, Wang S, Vessella R, True LD, Hood L: Prostate-localised and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res. 1999, 59: 4180-4184.PubMed
74.
Karpf AR, Peterson PW, Rawlins JT, Dalley BK, Yang Q, Albertsen H, Jones DA: Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2 and 3 genes in colon tumor cells. Proc Natl Acad Sci USA. 1999, 96: 14007-14012. 10.1073/pnas.96.24.14007.CrossRefPubMedPubMedCentral
75.
Hilsenbeck SG, Friedrichs WE, Schiff R, O'Connell P, Hansen RK, Osborne CK, Fuqua SA: Statistical analysis of array expression data as applied to the problem of tamoxifen resistance. J Natl Cancer Inst. 1999, 91: 453-459. 10.1093/jnci/91.5.453.CrossRefPubMed
76.
Chang YE, Laimins LA: Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomarvirus type 31. J Virol. 2000, 74: 4174-4182. 10.1128/JVI.74.9.4174-4182.2000.CrossRefPubMedPubMedCentral
77.
Bubendorf L, Kolmer M, Kononen J, Koivisto P, Mousses S, Chen Y, Mahlamaki E, Schraml P, Moch H, Willi N, Elkahloun AG, Pretlow TG, Gasser TC, Mihatsch MJ, Sauter G, Kallioniemi OP: Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J Natl Cancer Inst. 1999, 91: 1758-1764. 10.1093/jnci/91.20.1758.CrossRefPubMed
78.
Elek J, Park KH, Narayanan R: Microarray-based expression profiling in prostate tumors. In Vivo. 2000, 14: 173-182.PubMed
79.
Carlisle AJ, Prabhu VV, Eikehloun A, Hudson J, Trent JM, Linehan WM, Williams ED, Emmert-Buck MR, Liotta LA, Munson PJ, Krizman DB: Development of a prostate cDNA microarray and statistical gene expression analysis package. Mol Carcinog. 2000, 28: 12-22. 10.1002/(SICI)1098-2744(200005)28:1<12::AID-MC3>3.0.CO;2-Q.CrossRefPubMed
80.
Villaret DB, Wang T, Dillon D, Xu J, Sivam D, Cheever MA, Reed SG: Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis. Laryngoscope. 2000, 110: 374-381. 10.1097/00005537-200003000-00008.CrossRefPubMed
81.
Xu J, Stolk JA, Zhang X, Silva SJ, Houghton RL, Matsumara M, Vedvick TS, Leslie KB, Badaro R, Reed SG: Identification of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res. 2000, 60: 1677-1682.PubMed
82.
Yang GP, Ross DT, Kuang WW, Brown PO, Weigel RJ: Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes. Nucleic Acids Res. 1999, 27: 1517-1523. 10.1093/nar/27.6.1517.CrossRefPubMedPubMedCentral
83.
Wang T, Hopkins D, Schmidt C, Silva S, Houghton R, Takita H, Repasky E, Reed SG: Identification of genes differentially over-expressed in lung squamous cell carcinoma using combination of cDNA subtraction and microarray analysis. Oncogene. 2000, 19: 1519-1528. 10.1038/sj/onc/1203457.CrossRefPubMed
84.
Khan J, Simon R, Bittner M, Chen Y, Leighton SB, Pohida T, Smith PD, Jiang Y, Gooden GC, Trent JM, Meltzer PS: Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res. 1998, 58: 5009-5013.PubMed
85.
Scholl FA, Betts DR, Niggli FK, Schafer BW: Molecular features of a human rhabdomyosracoma cell line with spontaneous metastatic progression. Br J Cancer. 2000, 82: 1239-1245. 10.1054/bjoc.1999.1069.CrossRefPubMedPubMedCentral
86.
Wang K, Gan L, Jeffery E, Gayle M, Bown AM, Skelly M, Nelson PS, Ng WV, Schummer M, Hood L, Mulligan J: Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray. Gene. 1999, 299: 101-108. 10.1016/S0378-1119(99)00035-9.CrossRef
87.
Moch H, Schrami P, Bubendorf L, Mirlacher M, Konenen J, Gasser T, Mihatsch MJ, Kallioniemi O, Sauter G: High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am J Pathol. 1999, 154: 981-986.CrossRefPubMedPubMedCentral
88.
Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LMG, Pe'er J, Trent JM, Meltzer PS, Hendrix MJ: Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol. 1999, 155: 739-752.CrossRefPubMedPubMedCentral
89.
Welford SM, Gregg J, Chen E, Garrison D, Sorensen PH, Denny CT, Nelson SF: Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridisation. Nucleic Acids Res. 1998, 26: 3059-3065. 10.1093/nar/26.12.3059.CrossRefPubMedPubMedCentral
90.
Li H, Schrick JJ, Fewell GD, MacFarland KL, Witte DP, Bodenmiller DM, Hsieh-Li HM, Su C-Y, Potter SS: Novel strategy yields candidate Gsh-1 homeobox gene targets using hypothalamus progenitor cell lines. Dev Biol. 1999, 211: 64-76. 10.1006/dbio.1999.9304.CrossRefPubMed
91.
Lee SB, Huang K, Palmer R, Truong VB, Herzlinger D, Kolquist KA, Wong J, Paulding C, Yoon SK, Gerald W, Oliner JD, Haber DA: The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell. 1999, 98: 663-673.CrossRefPubMed
92.
Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR: The genetic program of hematopoietic stem cells. Science. 2000, 288: 1635-1640. 10.1126/science.288.5471.1635.CrossRefPubMed
93.
Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J: Identification of Cd36 (fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet. 1999, 21: 76-83. 10.1038/5013.CrossRefPubMed
94.
Phillips J, Eberwine JH: Antisense RNA amplfication: a linear amplification method for analysing the mRNA population from single living cells. Methods. 1996, 10: 283-288. 10.1006/meth.1996.0104.CrossRefPubMed
95.
Trenkle T, Welsh J, Jung B, Mathieu-Daude F, McClelland M: Non-stoichiometric reduced complexity probes for cDNA arrays. Nucleic Acids Res. 1998, 26: 3883-3891. 10.1093/nar/26.17.3883.CrossRefPubMedPubMedCentral
96.
Wang E, Miller LD, Ohnmacht GA, Liu ET, Marincola FM: High-fidelity mRNA amplification for gene profiling. Nat Biotechnol. 2000, 18: 457-459. 10.1038/74546.CrossRefPubMed
97.
Afshari CA, Nuwaysir EF, Barrett JC: Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation. Cancer Res. 1999, 59: 4759-4760.PubMed
98.
Nuwaysir EF, Bittner M, Trent J, Barrett JC, Afshari CA: Microarrays and toxicology: The advent of toxicogenomics. Mol Carcinog. 1999, 24: 153-159. 10.1002/(SICI)1098-2744(199903)24:3<153::AID-MC1>3.3.CO;2-G.CrossRefPubMed
99.
Kononen J, Bebendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP: Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998, 4: 844-847.CrossRefPubMed
Metadata
Title
Applications of microarray technology in breast cancer research
Author
Colin S Cooper
Publication date
01-06-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr291

Other articles of this Issue 3/2001

Breast Cancer Research 3/2001 Go to the issue

Commentary

Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy?

Commentary

More breast cancer genes?

Commentary

Telomerase and breast cancer

Research article

Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy

Commentary

The complexities of breast cancer desmoplasia

Research article

Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits