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Breast Cancer Research
Published in: Breast Cancer Research 3/2001

01-06-2001 | Commentary

Telomerase and breast cancer

Authors: Brittney-Shea Herbert, Woodring E Wright, Jerry W Shay

Published in: Breast Cancer Research | Issue 3/2001

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Abstract

Current therapies for breast cancer include treatments that are toxic and often result in drug resistance. Telomerase, a cellular reverse transcriptase that maintains the ends of chromosomes (telomeres), is activated in the vast majority of breast cancers (over 90% of breast carcinomas) but not in normal adjacent tissues. Telomerase is thus an attractive target for both diagnosis and therapy because of its distinct pattern of expression. We address the use of telomerase in the diagnostics of breast pathology, as well as the use of telomerase inhibitors in the treatment and prevention of breast cancer.
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Metadata
Title
Telomerase and breast cancer
Authors
Brittney-Shea Herbert
Woodring E Wright
Jerry W Shay
Publication date
01-06-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr288

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