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Breast Cancer Research
Published in: Breast Cancer Research 3/2011

01-06-2011 | Viewpoint

Waking up dormant tumors

Authors: Joyce C Tse, Raghu Kalluri

Published in: Breast Cancer Research | Issue 3/2011

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Abstract

As appreciation grows for the contribution of the tumor microenvironment to the progression of cancer, new evidence accumulates to support that the participation of stromal cells can extend beyond the local environment. Recently, Elkabets and colleagues demonstrated a systemic interaction between cancer cells and distant bone marrow cells to support the growth of otherwise indolent tumor cells at a secondary site, raising thought-provoking questions regarding the involvement of stromal cells in maintaining metastatic dormancy.
Literature
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Wels J, Kaplan RN, Rafii S, Lyden D: Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev. 2008, 22: 559-574. 10.1101/gad.1636908.CrossRefPubMedPubMedCentral
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Joyce JA: Therapeutic targeting of the tumor microenvironment. Cancer Cell. 2005, 7: 513-520. 10.1016/j.ccr.2005.05.024.CrossRefPubMed
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McAllister SS, Weinberg RA: Tumor-host interactions: a far-reaching relationship. J Clin Oncol. 2010, 28: 4022-4028. 10.1200/JCO.2010.28.4257.CrossRefPubMed
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McAllister SS, Gifford AM, Greiner AL, Kelleher SP, Saelzler MP, Ince TA, Reinhardt F, Harris LN, Hylander BL, Repasky EA, Weinberg RA: Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell. 2008, 133: 994-1005. 10.1016/j.cell.2008.04.045.CrossRefPubMedPubMedCentral
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Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirström K, Magnusson K, Ebert BL, Pontén F, Weinberg RA, McAllister SS: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest. 121: 784-799.
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Ong CH, Bateman A: Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis. Histol Histopathol. 2003, 18: 1275-1288.PubMed
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Ho JC, Ip YC, Cheung ST, Lee YT, Chan KF, Wong SY, Fan ST: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology. 2008, 47: 1524-1532. 10.1002/hep.22191.CrossRefPubMed
Metadata
Title
Waking up dormant tumors
Authors
Joyce C Tse
Raghu Kalluri
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2872

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