Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 3/2001

01-06-2001 | Commentary

The complexities of breast cancer desmoplasia

Author: Rosemary A Walker

Published in: Breast Cancer Research | Issue 3/2001

Login to get access

Abstract

The stromal, or 'desmoplastic', responses seen histologically in primary breast carcinomas can vary from being predominantly cellular (fibroblasts/myofibroblasts) with little collagen to being a dense acellular tissue. The mechanisms underlying the stromal response are complex; paracrine activation of myofibroblasts by growth factors is important but the contribution of cytokines/chemokines should not be ignored. A recent xenograft study has proposed that platelet-derived growth factor (PDGF) is the initiator of the desmoplastic response, but this has not been confirmed by (limited) analyses in vivo. Further studies are required to elaborate the mechanisms of the desmoplastic response, to determine its role in breast cancer progression and whether it is the same for all carcinomas.
Literature
1.
Jackson JG, Orr JW: The ducts of carcinomatous breasts with particular reference to connective tissue changes. J Pathol Bacteriol. 1957, 74: 265-273.CrossRef
2.
Barsky SH, Rao CN, Grotendorst GR, Liotta LA: Increased content of type V collagen in desmoplasia of human breast carcinoma. Am J Pathol. 1982, 108: 276-283.PubMedPubMedCentral
3.
Lagacé R, Grimaud J-A, Schürch , Seemayer TA: Myofibroblastic stromal reaction in carcinoma of the breast: variations of collagenous matrix and structural glycoproteins. Virchows Arch. 1985, 408: 49-59.CrossRef
4.
Dvorak HF, Dickersin GR, Dvorak AM, Manseau EJ, Pyne K: Human breast carcinoma: fibrin deposits and desmoplasia. Inflammatory cell type and distribution. Microvasculature and Infarction. J Natl Cancer Inst. 1981, 67: 335-345.PubMed
5.
Dvorak HF: Tumours: wounds that do not heal. Similarities between tumour stroma generation and healing. N Engl J Med. 1986, 315: 1650-1659.CrossRefPubMed
6.
Peres R, Betsholtz C, Westermark B, Heldin C-H: Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines. Cancer Res. 1987, 47: 3425-3429.PubMed
7.
Ethier SP: Growth factor synthesis and human breast cancer progression. J Natl Cancer Inst. 1995, 87: 964-973.CrossRefPubMed
8.
Horgan K, Jones DL, Mansel RE: Mitogenicity of human fibroblasts in vivo for human breast cancer cells. Br J Surg. 1987, 74: 227-229.CrossRefPubMed
9.
Ronnov-Jessin L, Petersen OW: Induction of α-smooth muscle actin by transforming growth factor-β1 in quiescent human breast gland fibroblasts. Lab Invest. 1993, 68: 696-707.
10.
Ellis MJC, Singer C, Hornby A, Rasmussen A, Cullen KJ: Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res Treat. 1994, 31: 249-261.CrossRefPubMed
11.
Bronzert DA, Pantazis P, Antoniades HN, Kasid A, Davidson N, Dickson RB, Lippman ME: Synthesis and secretion of platelet derived growth factor by human breast cancer cell lines. Proc Natl Acad Sci USA. 1987, 84: 5763-5767.CrossRefPubMedPubMedCentral
12.
13.
Shao Z-M, Nguyen M, Barsky SH: Human breast carcinoma desmoplasia is PDGF initiated. Oncogene. 2000, 19: 4337-4345. 10.1038/sj/onc/1203785.CrossRefPubMed
14.
Dickson RB, Kasid A, Huff KC, Bates SE, Knabbe C, Bronzert D, Gelmann EP, Lipmann ME: Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 β-estradiol or vH-ras oncogene. Proc Natl Acad Sci USA. 1987, 84: 837-841.CrossRefPubMedPubMedCentral
15.
Basset P, Bellocq JP, Woy C, Stoll I, Huton P, Limacher JM, Podhajcer DL, Chenard MP, Rio MC, Chambon P: A novel metalloproteinase gene specificity expressed in stromal cells of breast carcinomas. Nature. 1990, 348: 699-704. 10.1038/348699a0.CrossRefPubMed
16.
Tomlinson J, Barsky SH, Nelson S, Singer S, Pezeshki B, Lee MC, Eilber F, Nguyen M: Different patterns of angiogenesis in sarcomas and carcinomas. Clin Cancer Res. 1999, 5: 3516-3522.PubMed
17.
Rasmussen BB, Rose C, Thorpe SM, Hou-Jenson K, Daehnfeldt JL, Palshof T: Histopathological characteristics and oestrogen receptor content in primary breast carcinoma. Virchows Arch. 1981, 390: 347-351.CrossRef
18.
De Jong JS, van Diest PJ, van der Valk, Baak JPA: Expression of growth factors, growth-inhibiting factors and their receptors in invasive breast cancer. I. An inventory in search of autocrine and paracrine loops. J Pathol. 1998, 184: 44-52. 10.1002/(SICI)1096-9896(199801)184:1<44::AID-PATH984>3.3.CO;2-8.CrossRefPubMed
19.
Walker RA, Dearing SJ, Gallacher B: Relationship of transforming growth factor β1 to extracellular matrix and stromal infiltrates in invasive breast carcinomas. Br J Cancer. 1994, 69: 1160-1165.CrossRefPubMedPubMedCentral
20.
Walker RA, Dearing SJ: Transforming growth factor β1 expression in in-situ and invasive breast cancers. Eur J Cancer. 1992, 28: 641-644.CrossRefPubMed
21.
Ronnov-Jenson L, Petersen OW, Bissel M: Cellular changes involved in the conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev. 1996, 76: 69-125.
22.
Jones JL, Glynn P, Walker RA: Expression of MMP-2 and MMP-9, their inhibitors and the activator MT1-MMP in primary breast carcinomas. J Pathol. 1999, 189: 161-168. 10.1002/(SICI)1096-9896(199910)189:2<161::AID-PATH406>3.0.CO;2-2.CrossRefPubMed
23.
De Jong JS, van Diest PJ, van der Valk P, Baak JPA: Expression of growth factors, growth-inhibiting factors, and their receptors in invasive breast cancer. II. Correlations with proliferation and angiogenesis. J Pathol. 1998, 184: 53-57. 10.1002/(SICI)1096-9896(199801)184:1<53::AID-PATH6>3.0.CO;2-7.CrossRefPubMed
24.
Devalaraja MN, Richmond A: Multiple chemotactic factors: fine control or redundancy?. Trends Pharmacol Sci. 1999, 20: 151-156. 10.1016/S0165-6147(99)01342-5.CrossRefPubMed
25.
Steffen CL, Ball-Mirth DK, Harding PA, Bhattacharyya N, Pillai S, Brigstock DR: Characterization of cell associated and soluble forms of connective tissue growth factor produced by fibroblast cells in vitro. Growth Factors. 1998, 15: 199-123.CrossRefPubMed
Metadata
Title
The complexities of breast cancer desmoplasia
Author
Rosemary A Walker
Publication date
01-06-2001
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr287

Other articles of this Issue 3/2001

Breast Cancer Research 3/2001 Go to the issue

Commentary

Telomerase and breast cancer

Meeting report

Update on endocrine aspects of breast cancer: Report from the 23rd San Antonio Breast Cancer Symposium, San Antonio, Texas, USA, 6-9 December 2000

Commentary

More breast cancer genes?

Research article

Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy

Research article

Low frequency of E-cadherinalterations in familial breast cancer

Review

Applications of microarray technology in breast cancer research
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits