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Breast Cancer Research
Published in: Breast Cancer Research 3/2011

01-06-2011 | Editorial

From bone to breast and back - the bone cytokine RANKL and breast cancer

Authors: Lorenz C Hofbauer, Tilman D Rachner, Christine Hamann

Published in: Breast Cancer Research | Issue 3/2011

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Abstract

Receptor activator of nuclear factor-κB ligand (RANKL) plays a pivotal role in regulating bone homeostasis. Osteoporosis and malignant bone disease secondary to breast cancer are characterized by enhanced RANKL production and increased bone turnover. Thus, denosumab, a monoclonal antibody to RANKL, has been developed and is now approved for various bone loss conditions. Recent results indicate that RANKL may also promote the development and osseous migration of breast cancer.
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Metadata
Title
From bone to breast and back - the bone cytokine RANKL and breast cancer
Authors
Lorenz C Hofbauer
Tilman D Rachner
Christine Hamann
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2842

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