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01-06-2011 | Review

Interpreting breast international group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer

Authors: Meredith M Regan, Karen N Price, Anita Giobbie-Hurder, Beat Thürlimann, Richard D Gelber, for the International Breast Cancer Study Group and BIG 1-98 Collaborative Group

Published in: Breast Cancer Research | Issue 3/2011

Abstract

The Breast International Group (BIG) 1-98 study is a four-arm trial comparing 5 years of monotherapy with tamoxifen or with letrozole or with sequences of 2 years of one followed by 3 years of the other for postmenopausal women with endocrine-responsive early invasive breast cancer. From 1998 to 2003, BIG -98 enrolled 8,010 women. The enhanced design f the trial enabled two complementary analyses of efficacy and safety. Collection of tumor specimens further enabled treatment comparisons based on tumor biology. Reports of BIG 1-98 should be interpreted in relation to each individual patient as she weighs the costs and benefits of available treatments.

Clinicaltrials.gov ID: NCT00004205.

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Title: Interpreting breast international group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer
Authors: Meredith M Regan
Karen N Price
Anita Giobbie-Hurder
Beat Thürlimann
Richard D Gelber
for the International Breast Cancer Study Group and BIG 1-98 Collaborative Group
Publication date: 01-06-2011
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 3/2011
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2837

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