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Breast Cancer Research
Published in: Breast Cancer Research 4/2010

01-12-2010 | Short communication

Genome-wide case-control study of musculoskeletal adverse events and functional genomics in women receiving aromatase inhibitors: going beyond associations

Author: James N Ingle

Published in: Breast Cancer Research | Special Issue 4/2010

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Excerpt

In postmenopausal women with early breast cancer, the third-generation aromatase inhibitors (AIs; anastrozole, exemestane, and letrozole) have been proven to be of value in multiple large well-conducted clinical trials as initial adjuvant endocrine therapy, after several years of tamoxifen, and as extended adjuvant endocrine therapy after about 5 years of tamoxifen [1‐8]. A recent American Society of Clinical Oncology clinical practice guideline stated that an AI should be used in the adjuvant setting either initially or after some period of tamoxifen therapy [9]. …
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Metadata
Title
Genome-wide case-control study of musculoskeletal adverse events and functional genomics in women receiving aromatase inhibitors: going beyond associations
Author
James N Ingle
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 4/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2746

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