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Breast Cancer Research
Published in: Breast Cancer Research 1/2000

01-02-2000 | Commentary

BRCA1 function in T lymphocytes: a cellular specificity of a different kind

Authors: Kevin Gardner, Edison T Liu

Published in: Breast Cancer Research | Issue 1/2000

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Abstract

Recent work by Mak et al demonstrates that mice carrying a T-cell-specific disruption of the brca1 gene display markedly impaired T-lymphocyte development and proliferation in the absence of any increased tendency for the formation of tumors. Interestingly, the extent of these defects was found to be highly dependent on cellular context. Contrasting the rather broad tissue expression pattern of brca1 against its exquisitely selective etiologic role in cancers of the breast and ovary, many of us are left to ponder - where is the specificity?
Literature
1.
Mak TW, Hakem A, McPherson A, Shehabeldin A, Zablocki E, Migon E, Duncan S, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J, Hakem H: Brca1 required for T cell lineage development but not TCR loci rearrangement. Nature Immunol. 2000, 1: 77-82. 10.1038/76950.CrossRef
2.
Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX: A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998, 17: 3115-3124. 10.1038/sj/onc/1202243.CrossRefPubMed
3.
Hakem R, de la Pompa JL, Elia A, Potter J, Mak TW: Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nature Genet. 1997, 16: 298-302.CrossRefPubMed
4.
5.
Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW: Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 2000, 404: 897-900. 10.1038/35009138.CrossRefPubMed
6.
Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A: DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature. 2000, 404: 510-514. 10.1038/35006670.CrossRefPubMedPubMedCentral
7.
Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX: Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nature Genet. 1999, 22: 37-43. 10.1038/8743.CrossRefPubMed
8.
Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A: Immature thymocytes undergoing receptor rearrangements are resistant to an atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med. 2000, 192: 891-898. 10.1084/jem.192.6.891.CrossRefPubMedPubMedCentral
9.
Aprelikova ON, Fang BS, Meissner EG, Cotter S, Campbell M, Kuthiala A, Bessho M, Jensen RA, Liu ET: BRCA1-associated growth arrest is RB-dependent. Proc Natl Acad Sci USA. 1999, 96: 11866-11871. 10.1073/pnas.96.21.11866.CrossRefPubMedPubMedCentral
Metadata
Title
BRCA1 function in T lymphocytes: a cellular specificity of a different kind
Authors
Kevin Gardner
Edison T Liu
Publication date
01-02-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr263

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